Dysfunction of the lower esophageal sphincter in disorders other than achalasia

Kaye, Michael

doi:10.1007/bf01070842

Cited by 16 publications

(3 citation statements)

References 30 publications

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“…5). Motility was abnormal in the remaining six patients also, but the patterns seen did not conform to the strict, and perhaps undesirably rigid (Hogan, Caflisch, and Winship 1969;Kaye, 1973), classifications that are currently fashionable. In…”

Section: Manometric Methodsmentioning

confidence: 75%

Oesophageal motor dysfunction in patients with diverticula of the mid-thoracic oesophagus

Kaye¹

1974

Thorax

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Section: Manometric Methodsmentioning

confidence: 75%

Oesophageal motor dysfunction in patients with diverticula of the mid-thoracic oesophagus

Kaye¹

1974

Thorax

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“…This led to the suggestion that achalasia is just one extreme of a spectrum of related motility disorders of the esophagus [9,10,16,17] al spasm to achalasia, as it has been observed in some patients, or treatment-induced motility changes in patients with achalasia [3][4][5][6][7][8][9]18] support this hypothesis of a spectrum of different interrelated diseases. The underlying mechanisms of these forms of impaired esophageal motor function might reflect different, and in some cases probably reversible, alteration of extrinsic or intrinsic innerration.…”

Section: Discussionmentioning

confidence: 80%

“…Several investigators reported difficulties in classifying different esophageal motility disorders [10,[15][16][17]. This led to the suggestion that achalasia is just one extreme of a spectrum of related motility disorders of the esophagus [9,10,16,17] al spasm to achalasia, as it has been observed in some patients, or treatment-induced motility changes in patients with achalasia [3][4][5][6][7][8][9]18] support this hypothesis of a spectrum of different interrelated diseases.…”

Section: Discussionmentioning

confidence: 99%

Motility changes in primary achalasia following pneumatic dilatation

1990

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The changes in esophageal motility after pneumatic dilatation were evaluated prospectively in 51 patients with achalasia. The patients were evaluated for a median of 14 months. Pneumatic dilatation led to a clinical improvement in 41 patients. On manometric evaluation, a significant decrease in lower esophageal sphincter pressure was observed (28.4 +/- 14.9 mmHg vs. 13.5 +/- 7.2 mmHg; p = 0.001); the resting pressure of the esophageal body dropped from 4.8 +/- 4.2 mmHg above gastric baseline to 0.1 +/- 3.9 mmHg below gastric baseline. After therapy, peristaltic activity was present in 10/51 (20%) patients; in 1 case, complete relaxation of the lower esophageal sphincter was recorded. Treatment-induced motility changes could not be predicted by clinical history or the lower esophageal sphincter pressure before or after therapy. However, the resting pressure of the esophageal body before and after therapy was significantly lower in these patients in whom peristalsis recurred after therapy than in patients with an unchanged motility pattern. The reappearance of peristaltic activity after pneumatic dilatation was unrelated to lower esophageal sphincter pressure. In conclusion, motility disturbances of the esophageal body in patients with achalasia do not simply reflect the functional obstruction of the lower esophageal sphincter. These findings support the hypothesis that achalasia is not a distinct motility disturbance but should be regarded as part of a broad spectrum of different interrelated esophageal motility disorders.

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Achalasia and Diffuse Esophageal Spasm

Castell¹

1976

Arch Intern Med

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Dysfunction of the lower esophageal sphincter in disorders other than achalasia

Cited by 16 publications

References 30 publications

Oesophageal motor dysfunction in patients with diverticula of the mid-thoracic oesophagus

Oesophageal motor dysfunction in patients with diverticula of the mid-thoracic oesophagus

Motility changes in primary achalasia following pneumatic dilatation

Achalasia and Diffuse Esophageal Spasm

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