Dysfunction of the Auditory System in Children With Hypothyroidism: A Systematic Review and Meta-Analysis

Zhang, Kathy; Fried, Jacob; Nguyen, Shaun A.; Meyer, Ted A.; White, David R.

doi:10.1097/aud.0000000000001082

Cited by 3 publications

(2 citation statements)

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“…Alternative rationales may exist for these findings, including variables unknown or not evaluated. For example, metabolic and endocrine disorders such as hypothyroidism [ 46 , 47 , 48 , 49 ], diabetes [ 50 , 51 ], and polycystic ovarian syndrome (PCOS) [ 52 , 53 ] have been associated with both hearing loss and alterations in vitamin A nutritional status. Subclinical hypothyroidism is particularly common during pregnancy, affecting an estimated 15.5% of pregnant women in the United States [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, hypothyroidism is associated with increased concentrations of β-carotene [ 46 , 47 ]. Maternal hypothyroidism and congenital hypothyroidism are also linked to neurosensory hearing loss [ 48 , 49 ], although less is known about how subclinical hypothyroidism may affect infant hearing. One study by Radetti et al failed to detected any significant association between maternal subclinical hypothyroidism and infant hearing outcomes [ 55 ], while a study by G et al observed that infants born to mothers with subclinical hypothyroidism had minor alterations in hearing which self-corrected within 6–8 months [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

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Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

et al. 2023

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The prenatal period is critical for auditory development; thus, prenatal influences on auditory development may significantly impact long-term hearing ability. While previous studies identified a protective effect of carotenoids on adult hearing, the impact of these nutrients on hearing outcomes in neonates is not well understood. The purpose of this study is to investigate the relationship between maternal and umbilical cord plasma retinol and carotenoid concentrations and abnormal newborn hearing screen (NHS) results. Mother–infant dyads (n = 546) were enrolled at delivery. Plasma samples were analyzed using HPLC and LC–MS/MS. NHS results were obtained from medical records. Statistical analysis utilized Mann–Whitney U tests and logistic regression models, with p ≤ 0.05 considered statistically significant. Abnormal NHS results were observed in 8.5% of infants. Higher median cord retinol (187.4 vs. 162.2 μg/L, p = 0.01), maternal trans-β-carotene (206.1 vs. 149.4 μg/L, p = 0.02), maternal cis-β-carotene (15.9 vs. 11.2 μg/L, p = 0.02), and cord trans-β-carotene (15.5 vs. 8.0 μg/L, p = 0.04) were associated with abnormal NHS. Significant associations between natural log-transformed retinol and β-carotene concentrations and abnormal NHS results remained after adjustment for smoking status, maternal age, and corrected gestational age. Further studies should investigate if congenital metabolic deficiencies, pesticide contamination of carotenoid-rich foods, maternal hypothyroidism, or other variables mediate this relationship.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

et al. 2023

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The association between thyroid disease and hearing loss: a meta-analysis

Gu,

Guo,

Wang

et al. 2024

Acta Oto-Laryngologica

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A Study on the Effects of Hypothyroidism on the Senses: A Comprehensive Narrative Review

LeVasseur,

Fogel,

Khanna

2024

Cureus

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Hypothyroidism has been found to have long-term effects on each of the senses, but with proper treatment, many of them can be significantly minimized. This paper analyzes the research on the impact of hypothyroidism on the senses of smell, taste, hearing, vision, and thermoregulation. Data were collected from the National Library of Medicine, PubMed, and Google Scholar databases using the keywords "hypothyroidism," "taste," "smell," "vision," "hearing," and "thermoregulation." Approximately 413 articles were found when searching with these parameters, and 30 were used in this paper. Studies were excluded if they were outside this paper's scope or older than 2012. Studies were included if they specifically focused on hypothyroidism and one of the five listed senses. Patients with hypothyroidism had a significantly increased risk of sensorineural hearing loss, decreased perception of the blue-yellow color axis, decreased sense of olfaction and number of olfactory bulbs, and decreased thermogenesis. Hypothyroidism was also found to show increased length of COVID-19-induced anosmia and decreased bitter taste perception. It can be concluded that hypothyroidism has many effects on the senses, particularly an increased risk of sensorineural hearing loss. More studies need to be done on these effects.

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Dysfunction of the Auditory System in Children With Hypothyroidism: A Systematic Review and Meta-Analysis

Abstract: Supplemental Digital Content is available in the text.

Cited by 3 publications

References 36 publications

Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

The association between thyroid disease and hearing loss: a meta-analysis

A Study on the Effects of Hypothyroidism on the Senses: A Comprehensive Narrative Review

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