Dysfunction of telomeric Cdc13-Stn1-Ten1 simultaneously activates the DNA damage and spindle checkpoints
Nathalie Grandin,
Michel Charbonneau
Abstract:Telomeres, the ends of eukaryotic linear chromosomes, are composed of repeated DNA sequences and specialized proteins, with the conserved Cdc13/CTC1-Stn1-Ten1 (CST) telomeric comple providing chromosome stability via telomere end-protection and regulation of telomerase accessibility. In the present study,SIZ1, coding for a SUMO E3 ligase, andTOP2(Top2 is a SUMO target for Siz1 and Siz2) were isolated as extragenic suppressors of temperature-sensitive mutants ofSaccharomyces cerevisiaeCST.ten1-sz, stn1-szandcdc… Show more
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