Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naïve Patients With Generalized Anxiety Disorder

Wang, Mei; Cao, Lingxiao; Li, Hailong; Xiao, Hongqi; Ma, Yulong; Liu, Shiyu; Zhu, Hongru; Yuan, Minlan; Qiu, Changjian; Huang, Xiaoqi

doi:10.3389/fpsyt.2021.758978

Cited by 2 publications

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References 50 publications

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“…RGS14 limits spatial memory by suppressing dendritic spine growth in hippocampal neurons and may be doing the same in the amygdala to limit anxiety‐like behavior (Evans, Parra‐Bueno, et al, 2018). This is supported by the fact that enhanced amygdala size, connectivity, and/or laterality are linked to anxiety disorders in humans, including social anxiety disorder, generalized anxiety disorder, separation anxiety disorder, panic disorder, and specific phobias (Etkin et al, 2009; Redlich et al, 2015; Roy et al, 2013; Shin & Liberzon, 2010; Suor et al, 2020; Wang et al, 2021).…”

Section: Implications For Rgs14 In Human Neurological Disease Statesmentioning

confidence: 98%

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

2022

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RGS14 is a multifunctional scaffolding protein that is highly expressed within postsynaptic spines of pyramidal neurons in hippocampal area CA2. Known roles of RGS14 in CA2 include regulating G protein, H‐Ras/ERK, and calcium signaling pathways to serve as a natural suppressor of synaptic plasticity and postsynaptic signaling. RGS14 also shows marked postsynaptic expression in major structures of the limbic system and basal ganglia, including the amygdala and both the ventral and dorsal subdivisions of the striatum. In this review, we discuss the signaling functions of RGS14 and its role in postsynaptic strength (long‐term potentiation) and spine structural plasticity in CA2 hippocampal neurons, and how RGS14 suppression of plasticity impacts linked behaviors such as spatial learning, object memory, and fear conditioning. We also review RGS14 expression in the limbic system and basal ganglia and speculate on its possible roles in regulating plasticity in these regions, with a focus on behaviors related to emotion and motivation. Finally, we explore the functional implications of RGS14 in various brain circuits and speculate on its possible roles in certain disease states such as hippocampal seizures, addiction, and anxiety disorders.

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Section: Implications For Rgs14 In Human Neurological Disease Statesmentioning

confidence: 98%

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

2022

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Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression

Thivisol

et al. 2023

Neuronal Signaling

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Paternal preconceptional health factors, such as exposures to stress, diet and exercise, have been found to significantly influence offspring phenotypes in a range of animal models. Preclinical studies have provided evidence that paternal stress is associated with increased stress responsivity and anxiety-related traits, particularly in male offspring. It was previously reported that a paternal history of maternal separation (MS) led to male offspring (PatMS) displaying reduced cautious behavior during exploration of a novel environment. The neural basis for that absence of behavioral moderation is unclear. Here, we investigated the adaptive behavioral responses of control and PatMS male offspring in the predator odour risk-assessment task (PORT). PatMS mice failed to moderate their behaviors in the presence of a predator odour trimethylthiazoline (TMT). c-Fos mapping revealed reduced cellular activation in fear-regulating brain regions of PatMS mice, such as in the cingulate cortex, dentate gyrus of the hippocampus, and the basolateral amygdala. Expression of the paternally imprinted gene Grb10 (previously identified as a key molecular regulator of risk-taking behavior) was unaltered in PatMS mice. However, other paternal imprinted genes such as Igf2 and PEG3 were differentially expressed in PatMS mice. Overall, our study provides the first evidence of an intergenerational influence of preconceptional paternal stress exposure on offspring brain function relevant to risk-taking behavior, which is also independent of Grb10 gene expression.

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Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naïve Patients With Generalized Anxiety Disorder

Cited by 2 publications

References 50 publications

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression

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