Dysfunction of Membrane-Receptor System of Blood Cells and Kidney Tissue in Experimental Diabetes Mellitus

Микаелян, Н. П.; Gurina, A. E.; Терентьев, А. А.

doi:10.1007/s10517-013-2011-x

Cited by 9 publications

(10 citation statements)

References 4 publications

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“…It has been observed that cellular membrane electrolyte transporter Na + -K + -ATPase dysfunction in diabetic subjects can be secondary to hyperglycemia [ 10 ]. Moreover, the functions of Ca 2+ -Mg 2+ -ATPase, Na + /Ca 2+ exchanger, and Ca 2+ pump, which are located in the cell membrane, mitochondria or endoplasmic reticulum, have been shown to be impaired in diabetes [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients

Hasona

Elasbali

2016

Medical Sciences

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Electrolytes and Lipids have always played significant roles, and changes in their concentrations gives good indications of disease progression in a number of non-communicable diseases. Diabetes mellitus is the most common metabolic disorder in the community. Diabetics may suffer from electrolyte disorders due to complications of diabetes mellitus and the medication they receive. Serum glucose, electrolytes (Na+, K+, Cl− and Ca++), and lipid profiles (total cholesterol, triglyceride, and HDL-c) were determined in 100 diabetics and in non-diabetic subjects. All the diabetic patients had a significant (p < 0.001) increase in glucose, total cholesterol, triglyceride, chloride and calcium levels. There was significant (p < 0.001) decrease in the serum levels of Na+ and K+ in all diabetics. It was concluded that differences in lipids and electrolytes found in diabetics may have great potential as a diagnostic tool in clinical practice and have a significant effect upon the risk of contracting many diseases.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients

Hasona

Elasbali

2016

Medical Sciences

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“…NKA activity might impact SGLTs by providing the driving force for their activity [146]. In murine models of diabetes, changes in NKA function are probably due to high glycaemic levels [155][156][157]159] and impaired insulin signalling [158]. Nevertheless, the results' heterogeneity does not allow to clearly define the insulin effect on NKA.…”

Section: Summary Of Evidence and Discussionmentioning

confidence: 99%

“…In the renal cortex of murine STZ models, NKA activity was reported as increased [155][156][157] or as reduced due to impaired insulin binding to its receptor [158]. In two of those reports with increased NKA activity, insulin treatment reduced it [155,157].…”

Section: Glucose Effects On Renal Glucosementioning

confidence: 97%

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Moreira

Muscelli

2020

Journal of Diabetes Research

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Renal proximal tubules reabsorb glucose from the glomerular filtrate and release it back into the circulation. Modulation of glomerular filtration and renal glucose disposal are some of the insulin actions, but little is known about a possible insulin effect on tubular glucose reabsorption. This review is aimed at synthesizing the current knowledge about insulin action on glucose handling by proximal tubules. Method. A systematic article selection from Medline (PubMed) and Embase between 2008 and 2019. 180 selected articles were clustered into topics (renal insulin handling, proximal tubule glucose transport, renal gluconeogenesis, and renal insulin resistance). Summary of Results. Insulin upregulates its renal uptake and degradation, and there is probably a renal site-specific insulin action and resistance; studies in diabetic animal models suggest that insulin increases renal SGLT2 protein content; in vivo human studies on glucose transport are few, and results of glucose transporter protein and mRNA contents are conflicting in human kidney biopsies; maximum renal glucose reabsorptive capacity is higher in diabetic patients than in healthy subjects; glucose stimulates SGLT1, SGLT2, and GLUT2 in renal cell cultures while insulin raises SGLT2 protein availability and activity and seems to directly inhibit the SGLT1 activity despite it activating this transporter indirectly. Besides, insulin regulates SGLT2 inhibitor bioavailability, inhibits renal gluconeogenesis, and interferes with Na+K+ATPase activity impacting on glucose transport. Conclusion. Available data points to an important insulin participation in renal glucose handling, including tubular glucose transport, but human studies with reproducible and comparable method are still needed.

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“…And the functions of Ca 2+ -Mg 2+ -ATPase, Na + /Ca 2+ exchanger and Ca 2+ pump, which are located in cell membrane, mitochondria or endoplasmic reticulum, have been shown to be impaired in diabetes [40,41]. Electrolyte disturbances within cells can be induced by them above mentioned.…”

Section: Discussionmentioning

confidence: 99%

Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus

Wang

Hou

Liu

et al. 2013

Cardiovasc Diabetol

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BackgroundThe prevalence of diabetes in China is increasing rapidly. However, scarce data are available on serum electrolyte levels in Chinese adults with diabetes, especially in those with cardiovascular complications. This study measured serum electrolyte levels and examined their relationship with macrovascular complications in Chinese adults with diabetes.MethodsThe three gender- and age-matched groups were enrolled into this analysis, which were 1,170 subjects with normal glucose regulation (NGR), 389 with impaired glucose regulation (IGR) and 343 with diabetes. Fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG), glycosylated hemoglobin A1c (HbA1c) and serum electrolyte levels were measured. Data collection included ankle brachial index results.ResultsSerum sodium and magnesium levels in the diabetes group were significantly decreased compared to the NGR group (sodium: 141.0 ± 2.4 vs. 142.1 ± 2.0 mmol/l; magnesium: 0.88 ± 0.08 vs. 0.91 ± 0.07 mmol/l, all P < 0.01), while the serum calcium level was significantly increased (2.36 ± 0.11 vs. 2.33 ± 0.09 mmol/l, P < 0.01). Multiple linear regression showed that serum sodium and magnesium levels in the diabetes group were negatively correlated with FPG, 2hPG and HbA1c (sodium: Std β = −0.35, -0.19, -0.25; magnesium: Std β = −0.29, -0.17, -0.34, all P < 0.01), while the serum calcium level was positively correlated with HbA1c (Std β = 0.17, P < 0.05). In diabetic subjects, serum sodium, magnesium and potassium levels were decreased in the subjects with the elevation of estimated glomerular filtration rates (P < 0.05). ANCOVA analysis suggested that serum magnesium level in subjects with diabetic macrovascular complications was significantly decreased compared with diabetic subjects without macrovascular complications after the effect of some possible confounding being removed (P < 0.05).ConclusionsSerum sodium and magnesium levels were decreased in Chinese subjects with diabetes, while the observed increase in calcium level correlated with increasing glucose level. Diabetic patients with macrovascular complications had lower serum magnesium level than those with no macrovascular complications.

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Dysfunction of Membrane-Receptor System of Blood Cells and Kidney Tissue in Experimental Diabetes Mellitus

Cited by 9 publications

References 4 publications

Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients

Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients

Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus

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