Dysfunction of lower urinary tract in patients with spinal cord injury

Schurch, Brigitte; Tawadros, Cécile; Carda, Stefano

doi:10.1016/b978-0-444-63247-0.00014-6

Cited by 20 publications

(14 citation statements)

References 157 publications

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“…Bladder dysfunction may be due to overactive bladder, which is secondary to excessive contractions of the detrusor muscle, or in contrary some individuals may have an underactive detrusor muscle that would require treatments for stimulating contractions in the detrusor muscle. In some other cases, symptoms may also result from excessive urethral sphincter contraction …”

Section: Introductionmentioning

confidence: 99%

“…In some other cases, symptoms may also result from excessive urethral sphincter contraction. 3 It is well known that a complex coordination of the neuronal circuit between the brain-spinal cord and bladderurethra is essential for normal micturition. The sacral micturition center (S2-S4), pontine micturition center, and cerebral cortex are responsible for the facilitation and inhibition of voiding.…”

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confidence: 99%

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Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

Ekiz

Kumral

Erşahin

et al. 2016

Neurourology and Urodynamics

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

Ekiz

Kumral

Erşahin

et al. 2016

Neurourology and Urodynamics

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“…Multiple sclerosis (MS) was not included in the present study: this might be due to a selection bias that the frequency of MS in Asian countries including Japan is lower than European countries, although bladder dysfunction is a common feature in MS [27]. Similarly, spinal traumatic injury was not included in the present study: since our urodynamic laboratory belongs to a university hospital, and spinal cord injured patients might be referred to the specific center for spinal cord injury, although bladder dysfunction is a very common feature in spinal cord injury [28].…”

Section: Pol Scientificmentioning

confidence: 99%

Neurologic diseases that cause female urinary retention

Nakamura

Sakakibara

Sugiyama

et al. 2016

Bladder

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A B S T R A C T OBJECTIVE:The pathogenesis of female urinary retention is not well known. Hence, we systematically investigated the frequency of diseases that underlie female urinary retention in a urodynamic laboratory. METHODS:We analyzed data from 450 consecutive female patients. Data registries included the diagnosis, lower urinary tract symptom questionnaires, urodynamic study results, and neurologic exam observations. Complete urinary retention is defined as mean post-void residual (PVR) urine volume > 100 ml with no voluntary void at all; whereas incomplete urinary retention is defined as mean PVR urine volume > 100 ml after voluntary partial void. RESULTS:Sixty of the 450 female patients visiting our lab (13%) had urinary retention with 4 (6.7%) of these having complete retention and 56 (93.3%) having incomplete retention. The most common underlying disease in these 60 patients was lumbar spondylosis (LS), 38.3% (with 16 patients having LS alone and 7 having LS & diabetic distal polyneuropathy [DPN]), multiple system atrophy (MSA), 18.3%, and DPN, 14.4% (with 2 patients having DPN alone and 7 having LS & DPN), followed by drug-induced retention (e.g., by antidepressants), 8.3%, acute myelitis of possible demyelinating origin, 5.0%, and other etiologies. An underactive detrusor was the major urodynamic findings in those patients. CONCLUSIONS:The present study revealed that common etiologies for female urinary retention are neurologic, e.g., an underactive detrusor due to MSA, age-related LS, and lifestyle-related DPN. Therefore LS and DPN, both common diseases, should also become major treatment targets in order to maximize patients' quality of life.

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“…In mammals, storage and elimination of urine requires the coordinated activity of sympathetic, parasympathetic, and somatic efferent motor pathways involving both segmental spinal reflexes (e.g., the activation of the external urethral sphincter [EUS] during bladder filling) and the well‐studied spino‐bulbo‐spinal reflexes that coordinate simultaneous bladder contraction and EUS relaxation during voiding (Fowler et al, 2008 ). Thus, it is not surprising that lower urinary tract (LUT) dysfunction is a common comorbidity in individuals with neurological disease or central nervous system injury (Phe et al, 2016 ; Podnar et al, 2006 ; Sakakibara, 2015 ; Schurch et al, 2015 ; Winge, 2015 ) that significantly impacts the health and quality of life of both patients and caregivers. Therefore, it is vital to investigate LUT dysfunction using approaches that include assessment of both the bladder and EUS function.…”

Section: Introductionmentioning

confidence: 99%

Serial transurethral cystometry: A novel method for longitudinal evaluation of reflex lower urinary tract function in adult female rats

Qureshi

Kung

Hou

et al. 2022

Physiological Reports

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Aims The aim of the study is to develop a minimally invasive method for longitudinal evaluation of lower urinary tract function that allows for simultaneous measurements of bladder pressure and external urethral sphincter (EUS) electromyographic (EMG) activity. Methods To evaluate the reliability of serial transurethral cystometry (STUC), rats ( n = 12) underwent three sessions of STUC, one session a week for 3 weeks. During each session, rats were anesthetized with ketamine–xylazine (90 mg/kg and 10 mg/kg), and micturition reflex data were acquired using transurethral cystometry and percutaneous recording of EUS (EMG) activity during continuous infusion of saline into the bladder. The reliability and consistency of the STUC method were assessed using intra‐class correlation (ICC) analysis and repeated measures ANOVA. Results ICC values calculated from five successive events during the first micturition session indicate good to excellent reliability for measurements of peak bladder pressure, threshold bladder pressure, minimum bladder pressure, volume threshold, duration of EUS bursting, and number of EUS burst events. Across the three recording sessions no significant difference was observed in peak bladder pressure, threshold bladder pressure, minimum bladder pressure, volume threshold, number of EUS burst events, and duration of EUS bursting using repeated measures ANOVA. Conclusion Serial transurethral cystometry under ketamine–xylazine anesthesia with simultaneous percutaneous EUS EMG recording is a novel, reliable, accurate, and minimally invasive method for quantitative assessment of lower urinary tract (LUT) function in adult female rats over extended periods of time.

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Dysfunction of lower urinary tract in patients with spinal cord injury

Cited by 20 publications

References 157 publications

Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

Neurologic diseases that cause female urinary retention

Serial transurethral cystometry: A novel method for longitudinal evaluation of reflex lower urinary tract function in adult female rats

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