Dysfunction of fronto-limbic brain circuitry in depression

Liao, Caizhi; Feng, Zhanchun; Zhou, Dan; Dai, Qi; Xie, Bing; Ji, Bing; Wang, X.

doi:10.1016/j.neuroscience.2011.10.053

Cited by 49 publications

(32 citation statements)

References 26 publications

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“…Furthermore, a number of studies have found that in addition to increased recruitment of the right DLPFC, people with depression show relatively increased recruitment of the amygdala while processing salient, positive emotional stimuli (Jaworska et al, 2015). One study also reported correlated increase in the recruitment of the bilateral amygdala and right DLPFC in people with depression while processing positive emotional facial expressions (Liao et al, 2012). Moreover, as with people recovered from AN, a few studies investigating differences in neural activation in response to positive social–emotional stimuli between people recovered from depression and HC participants have reported no significant differences in the recruitment of the amygdala (Dutra, 2012; Kerestes et al, 2012).…”

Section: Discussionmentioning

confidence: 96%

FMRI Study of Neural Responses to Implicit Infant Emotion in Anorexia Nervosa

et al. 2017

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Difficulties in social–emotional processing have been proposed to play an important role in the development and maintenance of anorexia nervosa (AN). Few studies, thus far, have investigated neural processes that underlie these difficulties, including processing emotional facial expressions. However, the majority of these studies have investigated neural responses to adult emotional display, which may be confounded by elevated sensitivity to social rank and threat in AN. Therefore, the aim of this study was to investigate the neural processes underlying implicit processing of positively and negatively valenced infant emotional display in AN. Twenty-one adult women with AN and twenty-six healthy comparison (HC) women were presented with images of positively valenced, negatively valenced, and neutral infant faces during a fMRI scan. Significant differences between the groups in positive > neutral and negative > neutral contrasts were investigated in a priori regions of interest, including the bilateral amygdala, insula, and lateral prefrontal cortex (PFC). The findings revealed that the AN participants showed relatively increased recruitment while the HC participants showed relatively reduced recruitment of the bilateral amygdala and the right dorsolateral PFC in the positive > neutral contrast. In the negative > neutral contrast, the AN group showed relatively increased recruitment of the left posterior insula while the HC groups showed relatively reduced recruitment of this region. These findings suggest that people with AN may engage in implicit prefrontal down-regulation of elevated limbic reactivity to positively social–emotional stimuli.

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Section: Discussionmentioning

confidence: 96%

FMRI Study of Neural Responses to Implicit Infant Emotion in Anorexia Nervosa

et al. 2017

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“…These different findings in different affective states are supported by neuroimaging studies. These studies show altered activity in limbic bipolar patients in both manic (Altshuler et al., ) and depressive states (Liao et al., ) during the evaluation of emotional stimuli with different patterns of activation and functional connectivity in the different disorder phases (Hulvershorn et al., ; Cerullo et al., ).…”

Section: Discussionmentioning

confidence: 97%

Emotional Reactivity in Bipolar Depressed Patients

et al. 2014

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“…52 Rostral middle frontal gyrus, part of DLPFC, has an essential role in mood regulation, working memory and problem solving. 53 Abnormalities of DLPFC have been broadly reported in post-mortem, 26 neuroanatomical, 50 functional neuroimaging 54, 55, 56 and neuropsychological studies 57 in MDD patients. Consistent with our study, increased cortical thickness in right rostral middle frontal gyrus was also observed by van Eijndhoven et al 19 in first-episode, medication-free MDD patients.…”

Section: Discussionmentioning

confidence: 99%

Regional increases of cortical thickness in untreated, first-episode major depressive disorder

et al. 2014

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The large majority of structural MRI studies of major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients in whom course of illness and treatment effects may impact anatomic measurements. Further, in few studies, separate measurements of cortical thickness and surface area have been performed that reflect different neurobiological processes regulated by different genetic mechanisms. In the present study, we investigated both cortical thickness and surface area in first-episode, treatment-naïve, mid-life MDD to elucidate the core pathophysiology of this disease and its early impact on the brain. We observed increased cortical thickness in the right hemisphere, including medial orbitofrontal gyrus, pars opercularis, rostral middle frontal gyrus and supramarginal gyrus. Increased thickness of rostral middle frontal gyrus was negatively related with depression severity on the Hamilton Depression Rating Scale. Furthermore, MDD patients showed significantly increased associations in cortical thickness measurements among areas where increased cortical thickness was observed. Analysis of pial area revealed a trend toward increased surface area in the left parahippocampal gyrus in MDD. To permit comparison of our data with those of previous gray matter volume studies, voxel-based morphometry was performed. That analysis revealed significantly increased gray matter volume in left paracentral lobule, left superior frontal gyrus, bilateral cuneus and thalamus which form limbic-cortico–striato–pallido–thalamic loops. These changes in first-episode, treatment-naïve, mid-life MDD patients may reflect an active illness-related cortical change close to illness onset, and thus potentially provide important new insight into the early neurobiology of the disorder.

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Dysfunction of fronto-limbic brain circuitry in depression

Cited by 49 publications

References 26 publications

FMRI Study of Neural Responses to Implicit Infant Emotion in Anorexia Nervosa

FMRI Study of Neural Responses to Implicit Infant Emotion in Anorexia Nervosa

Emotional Reactivity in Bipolar Depressed Patients

Regional increases of cortical thickness in untreated, first-episode major depressive disorder

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