Dysfunction of default mode network characterizes generalized anxiety disorder relative to social anxiety disorder and post-traumatic stress disorder

Yuan, Minlan; Liu, Bo; Yang, Bicheng; Dang, Wen; Xie, Hua; Lui, Su; Qiu, Changjian; Zhu, Hongru; Zhang, Wei

doi:10.1016/j.jad.2023.04.099

Cited by 7 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although, both PTSD and GAD are stress-associated disorders and can happen together at the same time. However, there are striking differences between PTSD and GAD such as, symptoms of GAD cause inability to relax whereas symptoms of PTSD lead to restricted or diminished positive emotional response ( Price et al, 2019 ; Yuan et al, 2023 ). PTSD is diagnosed when symptoms last longer than at least one month and cause functional impairment and distress.…”

Section: Introductionmentioning

confidence: 99%

The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder

Iqbal,

Huang,

Xue

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

Post-traumatic stress disorder (PTSD) is a stress-associated complex and debilitating psychiatric disorder due to an imbalance of neurotransmitters in response to traumatic events or fear. PTSD is characterized by re-experiencing, avoidance behavior, hyperarousal, negative emotions, insomnia, personality changes, and memory problems following exposure to severe trauma. However, the biological mechanisms and symptomatology underlying this disorder are still largely unknown or poorly understood. Considerable evidence shows that PTSD results from a dysfunction in highly conserved brain systems involved in regulating stress, anxiety, fear, and reward circuitry. This review provides a contemporary update about PTSD, including new data from the clinical and preclinical literature on stress, PTSD, and fear memory consolidation and extinction processes. First, we present an overview of well-established laboratory models of PTSD and discuss their clinical translational value for finding various treatments for PTSD. We then highlight the research progress on the neural circuits of fear and extinction-related behavior, including the prefrontal cortex, hippocampus, and amygdala. We further describe different molecular mechanisms, including GABAergic, glutamatergic, cholinergic, and neurotropic signaling, responsible for the structural and functional changes during fear acquisition and fear extinction processes in PTSD.

show abstract

Section: Introductionmentioning

confidence: 99%