Dysfunction of CD27+IgD+ B cells correlates with aggravated systemic lupus erythematosus

Zhang, Wei; Wang, Yongfu; Hu, Fanlei; Fj, Lu; Wu, Tao; Feng, Yue-Lan; Li, Ké

doi:10.1007/s10067-022-06051-z

Cited by 7 publications

(13 citation statements)

References 29 publications

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“…4D ) [ 6 , 9 ]. As well as SLE, reduced frequencies of MZB have also been reported in SS, SSc, and COVID-19 [ 9 , 55 , 56 , 58–60 , 135 ]. The factors that result in this depletion in blood are not understood and could represent reduced cell survival or genesis, altered tissue distribution or increased differentiation into ASCs.…”

Section: Naïve B Cellsmentioning

confidence: 96%

“…The reciprocal reduction of MZB cells and the increase of ASCs in SLE could also support their differentiation into short-lived ASCs that are characteristic of SLE disease flares [ 27 ]. Also, as MZB depletion in COVID and SLE has been shown to be reversible following resolution of the infection and with treatment respectively, inflammatory factors can result in significant plasticity in this population [ 55 , 135 ]. The functional significance of depletion in MZB is unknown but could underly the increased susceptibility of patients to infection with encapsulated bacteria or defective B regulatory responses [ 140 , 141 ].…”

Section: Naïve B Cellsmentioning

confidence: 99%

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Human B-cell subset identification and changes in inflammatory diseases

Velounias

Tull

2022

Clinical and Experimental Immunology

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Our understanding of the B cell subsets found in human blood and their functional significance has advanced significantly in the past decade. This has been aided by the evolution of high dimensional phenotypic tools such as mass cytometry and single cell RNA sequencing which have revealed heterogeneity in populations that were previously considered homogenous. Despite this, there is still uncertainty and variation between studies as to how B cell subsets are identified and named. This review will focus on the most commonly encountered subsets of B cells in human blood and will describe gating strategies for their identification by flow and mass cytometry. Important changes to population frequencies and function in common inflammatory and autoimmune diseases will also be described.

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Section: Naïve B Cellsmentioning

confidence: 96%

Section: Naïve B Cellsmentioning

confidence: 99%

Human B-cell subset identification and changes in inflammatory diseases

Velounias

Tull

2022

Clinical and Experimental Immunology

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“…Overall, a negative correlation between autoantibody concentrations and frequency of unswitched-memory B cells suggests that this subset may be protective against autoimmunity. Thus, lower percentages of unswitched-memory B cells are seen in systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) patients, in whom higher concentrations of autoreactive antibodies are observed [ 15 , 16 , 17 ]. The increase in this B cell subpopulation in PRS might, therefore, represents an appropriate response to therapy, but further analyses should be performed in larger cohorts to draw the right conclusions.…”

Section: Discussionmentioning

confidence: 99%

Immunological Profiles in Parry–Romberg Syndrome: A Case–Control Study

Saulle,

Gidaro,

Donadoni

et al. 2024

JCM

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Background: Parry–Romberg syndrome (PRS) is a rare craniofacial disorder. The aim of this study is to provide information on the immunological profile of this pathology. Since PRS can be included in a wider spectrum of sclerodermic diseases, we propose a case–control study comparing a patient affected by PRS with one with a diagnosis of scleroderma, herein used as control (CTR). Methods: B lymphocyte, T lymphocyte, and monocyte phenotypes and functions were assessed by flow cytometry in influenza (Flu)- or anti cluster differentiation (CD)3/CD28-stimulated peripheral blood mononuclear cells (PBMCs). Cytokine concentration was evaluated as well in PBMC supernatants, plasma, and saliva by Luminex assay. Results: T and B lymphocytes were similarly activated in unstimulated PRS and CTR cells but differed following antigen stimulation. T helper (Th)17 lymphocytes were expanded in PRS compared to CTR; this increase correlated with higher interleukin (IL)-17 concentration. Conclusions: Our case–control study is the first to compare the immunological profiles of PRS and scleroderma patients. The higher percentage of Th17 cells in PRS suggests the use of anti-IL17 receptor monoclonal antibody in this rare disease; however, further studies with larger numbers of patients are needed to confirm our findings.

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“…In the same way, the decreased B cell subsets, such as UM B cells and B10 cells, may play immune regulatory roles in AOSD. The functions of UM B cells and B10 cells have been partially revealed in other rheumatic diseases [ 24 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

B cell subsets in adult-onset Still’s disease: potential candidates for disease pathogenesis and immunophenotyping

Fang

Xie

et al. 2023

Arthritis Res Ther

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Background Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in different rheumatic diseases, and their roles in AOSD are rarely investigated. This study aimed to unveil the B cell subset features in AOSD and provide evidence for B cell-based diagnosis and targeted therapies of AOSD. Methods B cell subsets in the peripheral blood of AOSD patients and healthy controls (HCs) were detected by flow cytometry. Firstly, the frequencies of B cell subsets were compared. Then, the correlation analysis was performed to explore the correlation between B cell subsets and clinical manifestations in AOSD. Finally, unbiased hierarchical clustering was performed to divide AOSD patients into three groups with different B cell subset features, and the clinical characteristics of the three groups were compared. Results The frequencies of B cell subsets were altered in AOSD patients. Disease-promoting subsets (such as naïve B cells, double negative B cells (DN B cells), and plasmablasts) increased, and potential regulatory subsets (such as unswitched memory B cells (UM B cells) and CD24hiCD27+ B cells (B10 cells)) decreased in the peripheral blood of AOSD patients. In addition, the altered B cell subsets in AOSD correlated with the clinical and immunological features, such as immune cells, coagulation features, and liver enzymes. Intriguingly, AOSD patients could be divided into three groups with distinct B cell immunophenotyping: group 1 (naïve B cells-dominant), group 2 (CD27+ memory B cells-dominant), and group 3 (precursors of autoantibody-producing plasma cells-dominant). Moreover, these three group patients demonstrated differential manifestations, including immune cells, liver or myocardial enzymes, coagulation features, and systemic score. Conclusions B cell subsets are significantly altered in AOSD patients, potentially contributing to the disease pathogenesis. These findings would inspire B cell-based diagnosis and targeted therapies for this refractory disease.

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Dysfunction of CD27+IgD+ B cells correlates with aggravated systemic lupus erythematosus

Cited by 7 publications

References 29 publications

Human B-cell subset identification and changes in inflammatory diseases

Human B-cell subset identification and changes in inflammatory diseases

Immunological Profiles in Parry–Romberg Syndrome: A Case–Control Study

B cell subsets in adult-onset Still’s disease: potential candidates for disease pathogenesis and immunophenotyping

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