Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Zhang, Peiyao; Xu, Qin; Dai, Jianping; Wang, Jun; Zhang, Ning; Luo, Yuejia

doi:10.1155/2014/846830

Cited by 27 publications

(18 citation statements)

References 36 publications

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“…In the present study, some brain areas including the temporal lobe, PHP, insular, and ACC showed increased DC values, in contrast to previous experiments 38 . The insular is believed to be involved in consciousness, and plays a role in diverse functions usually linked to emotion 39 .…”

Section: Discussioncontrasting

confidence: 99%

A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations

Shi

Liu

et al. 2017

Sci Rep

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Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the brain response of PSD in three different lesions. The brain responses of the three PSD subgroups were similar. However, each subgroup had its own characteristics of the brain network. In the temporal lobe subgroup, the right thalamus had increased degree centrality (DC) values which were different from the other two subgroups. In the frontal lobe subgroup, the left dorsolateral prefrontal cortex, caudate, and postcentral gyrus had increased DC values which were different from the other two subgroups. The hemodynamic response of PSD indicates that PSD has activities of similar emotional networks, of which the negative network realizes its function through the limbic system and default mode network. The brain network has unique characteristics for different lesion locations. The neurological function of the lesion location, the compensatory mechanism of the brain, and the mechanism of integrity and locality of the brain are the important factors in the individual emotional network.

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Section: Discussioncontrasting

confidence: 99%

A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations

Shi

Liu

et al. 2017

Sci Rep

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“…This indicates that WM damage in certain brain regions is associated with the development of PSD. A resting-state functional MRI (fMRI) study showed that altered functional connectivity in regions involved in affect was associated with higher levels of depression (Zhang et al 2014 ). Atrophy also seems to be an important predictor of PSD, as significant associations were found with frontal lobe atrophy (Tang et al 2013b ), subcortical atrophy (Astrom et al 1993 ; Starkstein et al 1988 ), and left inferior frontal gyrus atrophy (Fu et al 2010 ).…”

Section: Resultsmentioning

confidence: 99%

Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis

et al. 2017

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Several brain imaging markers have been studied in the development of post-stroke depression (PSD) and post-stroke apathy (PSA), but inconsistent associations have been reported. This systematic review and meta-analysis aims to provide a comprehensive and up-to-date evaluation of imaging markers associated with PSD and PSA. Databases (Medline, Embase, PsycINFO, CINAHL, and Cochrane Database of Systematic Reviews) were searched from inception to July 21, 2016. Observational studies describing imaging markers of PSD and PSA were included. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to examine the association between PSD or PSA and stroke lesion laterality, type, and location, also stratified by study phase (acute, post-acute, chronic). Other imaging markers were reviewed qualitatively. The search retrieved 4502 studies, of which 149 studies were included in the review and 86 studies in the meta-analyses. PSD in the post-acute stroke phase was significantly associated with frontal (OR 1.72, 95% CI 1.34–2.19) and basal ganglia lesions (OR 2.25, 95% CI 1.33–3.84). Hemorrhagic stroke related to higher odds for PSA in the acute phase (OR 2.58, 95% CI 1.18–5.65), whereas ischemic stroke related to higher odds for PSA in the post-acute phase (OR 0.20, 95% CI 0.06–0.69). Frequency of PSD and PSA is modestly associated with stroke type and location and is dependent on stroke phase. These findings have to be taken into consideration for stroke rehabilitation programs, as this could prevent stroke patients from developing PSD and PSA, resulting in better clinical outcome.Electronic supplementary materialThe online version of this article (doi:10.1007/s11065-017-9356-2) contains supplementary material, which is available to authorized users.

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“…Specifically, it is well documented that neonatal HI causes neuronal injury and neurochemical alterations in the hippocampus, amygdala, and prefrontal cortex (Aridas et al, 2014;Nuñez et al, 2007;Vannucci and Vannucci, 2005), areas that play a key role in emotional regulation (Delgado et al, 2008;Sanders et al, 2010). Furthermore, extensive human research has shown a high prevalence of depression and anxiety disorders in stroke survivors (Waje-Andreassen et al, 2013;Zhang et al, 2014), symptoms that hinder recovery or increase the risk of poor long-term functional outcome post-stroke (Sagen et al, 2009;Yuan et al, 2014). In line with this, a meta-analysis of data from adult animal models of ischemic stroke showed that, overall, antidepressant treatments improve significantly the behavioral score relevant to depression as well as infract volume post-stroke (McCann et al, 2014).…”

Section: Effects Of Maternal Separation and Neonatal Hypoxia-ischemiamentioning

confidence: 99%

Maternal separation prior to neonatal hypoxia‐ischemia: Impact on emotional aspects of behavior and markers of synaptic plasticity in hippocampus

Markostamou

Ioannidis

Dandi

et al. 2016

Intl J of Devlp Neuroscience

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 We examined the interaction between MS and ΝΗΙ on emotionality and markers of plasticity. Both MS and NHI increased anxiety levels, but only NHI induced depressionlike behavior. Maternal separation did not further increase emotionality in HI-treated rats. Both MS and NHI decreased synaptophysin levels in dentate gyrus and CA3 hippocampal areas. BDNF expression in CA3 was decreased only in the HI animals that were maternally-separated. AbstractExposure to early-life stress is associated with long-term alterations in brain and behavior, and may aggravate the outcome of neurological insults. This study aimed at investigating the possible interaction between maternal separation, a model of early stress, and subsequent neonatal hypoxia-ischemia on emotional behavior and markers of synaptic plasticity in hippocampus. Therefore, rat pups (N=60) were maternally separated for a prolonged (MS 180min) or a brief (MS 15min) period during the first six postnatal days, while a control group was left undisturbed. Hypoxia-ischemia was applied to a subgroup of each rearing condition on postnatal day 7. Emotional behavior was examined at three months of age and included assessments of anxiety (elevated plus maze), depression-like behavior (forced swimming) and spontaneous exploration (open field). Synaptic plasticity was evaluated based on BDNF and synaptophysin expression in CA3 and dentate gyrus hippocampal regions. We found that neonatal hypoxia-ischemia caused increased levels of anxiety, depression-like behavior and locomotor activity (ambulation). Higher anxiety levels were also seen in maternally separated rats (MS180min) compared to non-maternally separated rats, but prolonged maternal separation prior to HI did not potentiate the HI-associated effect. No differences among the three rearing conditions were found regarding depression-like behavior or ambulation. Immunohistochemical evaluation of synaptophysin revealed that both prolonged maternal separation (MS180min) and neonatal hypoxia-ischemia significantly reduced its expression in the CA3 and dentate gyrus. Decreases in synaptophysin expression in these areas were not exacerbated in rats that were maternally separated for a prolonged period prior to HI. Regarding BDNF expression, we found a significant decrease in immunoreactivity only in the hypoxic-ischemic rats that were subjected to the prolonged maternal separation paradigm. The above findings suggest that early-life stress prior to neonatal hypoxia-ischemia leads to significant alterations in synaptic plasticity of the dorsal hippocampus during adulthood, but does not exacerbate HI-related changes in emotional behavior.

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Dysfunction of Affective Network in Post Ischemic Stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Cited by 27 publications

References 36 publications

A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations

A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations

Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis

Maternal separation prior to neonatal hypoxia‐ischemia: Impact on emotional aspects of behavior and markers of synaptic plasticity in hippocampus

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