Dyschromatosis universalis hereditaria

Dyschromatosis universalis hereditaria: Infrequent genodermatoses in India

“…However, a few cases of DUH were described among Europeans, South Americans, Indians, and Saudi Arabians and in Tunisia. [ 3 4 5 6 7 8 9 ]…”

“…[ 6 ] Abnormalities of hair and nails have also been reported. [ 7 ] The histopathology typically shows a focal increase or decrease in melanin content of the basal layer (depending on the type of the lesion biopsied) and occasionally pigmentary incontinence. In a recent ultrastructural skin investigation, Nuber et al .…”

Dyschromatosis Universalis Hereditaria - Case Report of a Rare Genodermatosis in India

“…Once thought to be confined to Japan, DUH is being increasingly reported from other countries including India. [4,5] Although majority of cases show autosomal dominant pattern of inheritance, but may be recessive or sporadically inherited. In the past, it was considered to be a disorder of melanocyte number, but now, based on a recent electron microscopic study, it has been suggested that DUH may be a disorder of production of melanosomes in epidermal melanin unit.…”

Dyschromatosis universalis hereditaria: A rare case report from Northeast India

“…DUH is a rare genodermatoses characterised by hyperpigmented and hypopigmented macules which are variable in size and shape [1]. It is a spectrum of diseases which includes dyschromatosis universalis hereditaria (generalized form), dyschromatosis symmetrica hereditaria (localized form) and unilateral dermatomal pigmentary dermatosis (segmental form) [2].…”