Dysbiosis of oral microbiota in palmoplantar pustulosis patients

Kouno, Michiyoshi; Akiyama, Yurie; Minabe, Masaki; Iguchi, Naohiko; Nomura, Takeshi; Ishihara, Kazuyuki; Takahashi, Shinichi

doi:10.1016/j.jdermsci.2018.12.003

Cited by 9 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, smoking patients had more Firmicutes. This preliminary study showed oral dysbiosis in Japanese patients with PPP, particularly with concomitant PAO [71].…”

Section: Microbiomementioning

confidence: 61%

“…Interestingly, a significant difference was seen in the abundance of Staphylococcus between smoking and nonsmoking patients with PPP, with more bacteria found in patients who smoked [70]. Kouno et al [71] surveyed the microbiota of saliva collected from 12 patients with PPP (seven of whom had concomitant PAO) and ten healthy controls. They observed that patients with PAO had less Proteobacteria at the phyla level and less Hemophilus and more Prevotella at the genus level than healthy controls (p < 0.05).…”

Section: Microbiomementioning

confidence: 99%

“…The method of bacteria detection in these recent studies involved amplification and sequencing of bacterial ribosomal RNA genes rather than using culturing methods. This approach has the advantage of being able to identify dead bacteria as well as those that cannot be cultivated in laboratory conditions [70,71].…”

Section: Microbiomementioning

confidence: 99%

See 2 more Smart Citations

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

View full text Add to dashboard Cite

Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Mutations in IL36RN (a major predisposing factor for generalized pustular psoriasis) were found in selected patients with PPP and were associated with earlier disease onset. Studies have shown that the interleukin (IL)-17 and IL-36 pathways might be involved in the pathogenesis of PPP. A microbiome has been demonstrated in the vesicopustules of PPP, and an abundance of Staphylococcus appears to be increased by smoking. Improved understanding of the underlying etiopathogenesis of PPP has led to advances in treatment options, and targeted therapies for PPP have been evaluated or are under evaluation against more than 12 molecules in ongoing clinical trials.

show abstract

“…Moreover, smoking patients had more Firmicutes. This preliminary study showed oral dysbiosis in Japanese patients with PPP, particularly with concomitant PAO [71].…”

Section: Microbiomementioning

confidence: 61%

Section: Microbiomementioning

confidence: 99%

See 1 more Smart Citation

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

View full text Add to dashboard Cite

show abstract

“…Palmoplantar pustulosis (PPP) is a chronic inflammatory condition characterized by the recurrent appearance of crops of sterile pustules on the palms and soles ( Figure 1 and Figure 2 ), in conjunction with erythematous keratotic lesions that tend to crack, causing bleeding and pain 1 – 4 .…”

Section: Definition and Classificationmentioning

confidence: 99%

“…In 1930, Barber assigned this condition the name PPP and categorized it as a local pustular form of psoriasis, but this entity’s etiology and its links to other pathologies are still in contention 1 , 2 , 4 , 5 . Some proposed that PPP is a separate entity, despite PPP and PV sharing particular phenotypes, and in 2007 the International Psoriasis Council separated PPP and psoriasis into distinct entities 1 , 2 , 4 – 6 . In 2017, the European Rare and Severe Expert Network (ERASPEN) distinguished between psoriasis vulgaris (PV) and pustular psoriasis (PP) and recognized them as distinct phenotypes 1 , 2 , 4 – 6 .…”

Section: Definition and Classificationmentioning

confidence: 99%

Recent advances in palmoplantar pustulosis

Brunasso¹,

Massone²

2021

Fac Rev

View full text Add to dashboard Cite

Palmoplantar pustulosis (PPP) is a chronic inflammatory condition where crops of sterile pustules with erythematous keratotic lesions causing bleeding and pain appear on the palms and soles. Recently, the European Rare and Severe Expert Network considered PPP as a variant of pustular psoriasis with or without psoriasis vulgaris. The prevalence of PPP varies from 0.050 to 0.12%. PPP occurs more frequently in women and the highest prevalence occurred between the ages of 50 and 69 years. Nail psoriasis seems to be frequent in PPP, ranging from 30 to 76%, and psoriatic arthritis in 8.6 to 26% of PPP patients. Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and pustulotic arthro-osteitis are considered PPP-associated disorders. PPP has been reported with other co-morbidities such as psychiatric disorders, thyroid-associated disease, altered calcium homeostasis, gluten sensitivity diabetes, obesity, and dyslipidemia, but larger studies are required to prove such associations. Environmental exacerbating factors might contribute to the onset or worsening of PPP such as cigarette smoking, stress, focal infections, metal allergies, and drug intake. Genetic predisposition plays an important role in PPP. In PPP, both the innate and the adaptive immune systems are activated. The acrosyringeal expression of IL-17 has been demonstrated, indicating that the eccrine sweat gland is an active component of the skin barrier and an immune-competent structure. Increased levels of several inflammatory molecules, including IL-8, IL-1α, IL-1β, IL-17A, IL-17C, IL-17D, IL-17F, IL-22, IL-23A, and IL-23 receptor, have been detected in PPP biopsies. Increased serum levels of TNF-α, IL-17, IL-22, and IFN-γ have been detected in patients with PPP in comparison to healthy subjects, suggesting a similar inflammatory pattern to psoriasis vulgaris. Oral and tonsillar infections serve as trigger factors for PPP. Long-term therapy is required for many patients, but high-quality data are limited, contributing to uncertainty about the ideal approach to treatment.

show abstract