Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus

He, Yuan; Gong, Diping; Shi, Cong; Shao, Fangyang; Shi, Jiahao; Fei, Jian

doi:10.1111/odi.12657

Cited by 60 publications

(69 citation statements)

References 38 publications

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“…The searches on OPMDs resulted in inclusion of two studies on oral leukoplakia (Amer, Galvin, Healy, & Moran, ; Hu et al., ) and four on oral lichen planus (Choi et al., ; He et al., ; Kragelund & Keller, ; Wang et al., ) (Table ).…”

Section: Resultsmentioning

confidence: 99%

World Workshop on Oral Medicine VII: Targeting the oral microbiome Part 2: Current knowledge on malignant and potentially malignant oral disorders

et al. 2019

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Objective The World Workshop on Oral Medicine VII chose the oral microbiome as a focus area. Part 1 presents the methodological state of the science for oral microbiome studies. Part 2 was guided by the question: What is currently known about the microbiome associated with oral squamous cell carcinoma and potentially malignant disorders of the oral mucosa? Materials and Methods A scoping review methodology was followed to identify and analyse relevant studies on the composition and potential functions of the oral microbiota using high‐throughput sequencing techniques. The authors performed searches in PubMed and EMBASE. After removal of duplicates, a total of 239 potentially studies were identified. Results Twenty‐three studies on oral squamous cell carcinoma, two on oral leukoplakia and four on oral lichen planus were included with substantial differences in diagnostic criteria, sample type, region sequenced and sequencing method utilised. The majority of studies focused on bacterial identification and recorded statistically significant differences in the oral microbiota associated with health and disease. However, even when comparing studies of similar methodology, the microbial differences between health and disease varied considerably. No consensus on the composition of the microbiomes associated with these conditions on genus and species level could be obtained. Six studies on oral squamous cell carcinoma had included in silico predicted microbial functions (genes and/or pathways) and found some similarities between the studies. Conclusions Attempts to reveal the microbiome associated with oral mucosal diseases are still in its infancy, and the studies demonstrate significant clinical and methodological heterogeneity across disease categories. The immense richness and diversity of the microbiota clearly illustrate that there is a need for additional methodologically comparable studies utilising deep sequencing approaches in significant cohorts of subjects together with functional analyses. Our hope is that following the recipe as outlined in our preceding companion paper, that is Part 1, will enhance achieving this in the future and elucidate the role of the oral microbiome in oral squamous cell carcinoma and potentially malignant disorders of the oral mucosa.

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Section: Resultsmentioning

confidence: 99%

World Workshop on Oral Medicine VII: Targeting the oral microbiome Part 2: Current knowledge on malignant and potentially malignant oral disorders

et al. 2019

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“…Further, Leptotrichia species were recovered from healthy patients with oral cancer, premalignant oral lesion [18,28,33,56,91], edentulous infants [29], human vaginal fluid of sexually active and inactive individuals [30,32], HIV-seropositive and -seronegative patients [46], pancreatic cancer patients [18,66], black pigmented stain caries patients [63], and patients with halitosis (Table 2) [42,65,81,82]. Besides, Leptotrichia species were isolated from the blood [4,5,22,74], the amniotic fluid of a patient with a wound and respiratory difficulties [4], breast milk of obese women with gestational diabetes and normal weight [36], oral samples of a patient with new-onset rheumatoid arthritis [20], oral lichen planus patients [88], and even from fermenting Lees liquor [39]. Leptotrichia species were equally isolated from the blood and gastric fluid of patients with coronary artery disease (CAD), candidal esophagitis, chronic kidney disease, diabetic, duodenal ulcer, erythematous gastropathy, gastroesophageal reflux disease, gastric ulcer, hiatal hernia, reflux esophagitis, upper gastrointestinal bleeding, renal transplant, and sarcoidosis (Table 2) [16].…”

Section: Brief Additional Clinical Information On Leptotrichia Speciesmentioning

confidence: 99%

“…L. trevisanii was involved in 15 incidences of bacteremia. Eight cases each also involved Leptotrichia species and L. buccalis , six L. goodfellowii , three L. wadei , two L. hongkongensis , and one with L. shahii (Table 2) [4–6,9–15,17,21,22,33,42,74,78,85–88]. In cases involving L. trevisanii , seven were also associated with neutropenic fever [5,13,14,17,87], while five were associated with PBSCT [9,10], four had acute myelogenous leukemia (AML) [5,7 9,10,15] and multiple myelomas (MM) [4,9,13], two had stomatitis [10,14], three had NHL [9,87], and one had a catheter-related bloodstream infection [17].…”

Section: Brief Additional Clinical Information On Leptotrichia Speciesmentioning

confidence: 99%

“…and Lautropia spp. were found to increase significantly in oral lichen planus (OLP) patients [88]. The argument for this was that as OLP is an immune-related disease, the elevated colonization of these bacteria might be related to the local immune dysfunction of OLP, which again suggested that OLP is associated with dysbiosis of the oral microbiome [88].…”

Section: Association Between Leptotrichia and Halitosismentioning

confidence: 99%

“…were found to increase significantly in oral lichen planus (OLP) patients [88]. The argument for this was that as OLP is an immune-related disease, the elevated colonization of these bacteria might be related to the local immune dysfunction of OLP, which again suggested that OLP is associated with dysbiosis of the oral microbiome [88]. Kawanami et al [24] suggested that in a severe pneumonia patient, isolated L. wadei and other Leptotrichia species, together with mixed oral bacteria ( Enterococcus faecalis , E. casseliflavus , Veillonella parvula , V. atypica , V. dispar , Prevotella nanceiensis , Streptococcus spp.…”

Section: Association Between Leptotrichia and Halitosismentioning

confidence: 99%

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Leptotrichia species in human infections II

Eribe

Olsen

2017

Journal of Oral Microbiology

107

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Leptotrichia species are non-motile facultative anaerobic/anaerobic bacteria that are found mostly in the oral cavity and some other parts of the human body, in animals, and even in ocean sediments. Valid species include L. buccalis, L. goodfellowii, L. hofstadii, L. honkongensis, L. shahii, L. trevisanii, and L. wadei. Some species require serum or blood for growth. All species ferment carbohydrates and produce lactic acid that may be involved with tooth decay. Acting as opportunistic pathogens, they are involved in a variety of diseases, and have been isolated from immunocompromised but also immunocompetent individuals. Mucositis, oral lesions, wounds, and abscesses may predispose to Leptotrichia septicemia. Because identification of Leptotrichia species by phenotypic features occasionally lead to misidentification, genetic techniques such as 16S rRNA gene sequencing is recommended. Early diagnosis and treatment of leptotrichia infections is important for positive outcomes. Over the last years, Leptotrichia species have been associated with several changes in taxonomy and new associations with clinical diseases. Such changes are reported in this updated review.

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