Dysbiosis of human gut microbiome in young-onset colorectal cancer

Yang, Yongzhi; Li, Du; Shi, Debing; Kong, Cheng; Liu, Jianqiang; Liu, Guang; Li, Xinxiang; Ma, Yanlei

doi:10.1038/s41467-021-27112-y

Cited by 101 publications

(118 citation statements)

References 67 publications

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“…Other bacteria in the signature of CRC belonged to 4 species in the Firmicutes phylum (Clostridium, Dehalobacterium, Ruminococcus, and Oscillospira) and were found to correlate with several metabolic pathways, such as the endocannabinoid, secondary bile acid metabolism, or polyunsaturated fatty acids (PUFA) pathways [15]. Patient age-related differences have been described by Yang et al, a functional analysis revealing that young CRC-specific microbiota (Fusobacterium, Flavonifractor and Odoribacter genera) is also more supportive of proliferative and invasive cellular processes [21].…”

Section: Microbial Biomarkers Of Early Crc Developmentmentioning

confidence: 90%

Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions

Fratila

Ismaiel

Dumitraşcu

2022

Medicine and Pharmacy Reports

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Introduction. The role of probiotics/prebiotics in modulating the procarcinogenic effects of microbiota have been studied with inconclusive results. This systematic review aimed to identify the role of several studied interventions on the gut microbiota modulation in humans for the prevention and management of colorectal cancer (CRC). Methods. We conducted a systematic search using PubMed and Cochrane Central electronic databases, identifying clinical studies published within the last 20 years. We performed a qualitative analysis of eligible studies included in our review on each of the 4 investigated topics: CRC potential biomarkers, dietary interventions, probiotic administration in non-surgical and surgical patients, respectively. Results. A total of 54 studies involving healthy volunteers, in addition to colorectal adenoma and CRC patients were included in our qualitative synthesis. We were able to identify bacterial signatures of CRC including Fusobacterium nucleatum and Clostridium butyricum. Moreover, dietary supplementation with oligosaccharides or fibers increased short chain fatty acid-producing bacteria levels, thus inhibiting tumorigenesis. Furthermore, we have confirmed that Lactobacilli and Bifidobacterium intake modulates gut microbiota towards tumor suppression. We have also showed that probiotic intake around colectomy significantly reduces complications. Conclusions. Bacterial metabolism is strongly linked with colonic carcinogenesis and influenced by diet. Probiotics and prebiotics can act as microbiota modulators, suppressing epithelial proliferation and reversing DNA toxicity. As adjuvants to surgery or chemotherapy, Lactobacilli and Bifidobacteria decrease complications. Improved outcomes in CRC patients can possibly be achieved through future research directed towards the benefits of bacterial agents as tumor suppressors or as treatment of oncological therapy resistance.

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Section: Microbial Biomarkers Of Early Crc Developmentmentioning

confidence: 90%

Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions

Fratila

Ismaiel

Dumitraşcu

2022

Medicine and Pharmacy Reports

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“…Blautia ( Deng et al, 2021 ), Romboutsia ( Deng et al, 2021 ), and Streptococcus ( Deng et al, 2021 ; Jiang et al, 2021 ) were reportedly enriched in esophageal cancer ( Jiang et al, 2021 ). Streptococcus was also abundant in CRC ( Yang et al, 2021 ). Streptococcus is a Gram-positive bacteria in humans and is mostly associated with urinary tract infection, sepsis, endocarditis, and CRC.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Gut Microbiota in Patients With Clear Cell Renal Cell Carcinoma

Yang

Dong

et al. 2022

Front. Microbiol.

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Different gut microbiota is implicated in different diseases, including cancer. However, gut microbiota differences between individuals with clear cell renal cell carcinoma (ccRCC) and healthy individuals are unclear. Here, we analyzed gut microbiota composition in 51 ccRCC patients and 40 healthy controls using 16S rRNA sequencing analysis. We observed that Blautia, Streptococcus, [Ruminococcus]_torques_group, Romboutsia, and [Eubacterium]_hallii_group were dominant and positively associated with ccRCC. We isolated and cultured Streptococcus lutetiensis to characterize specific gut microbiota that promotes ccRCC and found that it promoted in vitro ccRCC proliferation, migration, and invasion via the TGF-signaling pathway. Interactions identified between the gut microbiota and ccRCC suggest the gut microbiota could serve as a potential non-invasive tool for predicting ccRCC risk and also function as a cancer therapy target.

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“…Interestingly, the only outlier in the stage-based classification (according to both microbial and human data, as illustrated in Figures 3A and B , respectively) correspond to the same patient (S165), who is a young-onset CC case (with an age significantly lower compared to all the other patients). Young-onset CC is known to have peculiar clinicopathological characteristics ( Akimoto et al, 2021 ), including a possibly different associated microbiota ( Yang et al, 2021 ). This might reasonably explain the behavior of that patient as an outlier.…”

Section: Discussionmentioning

confidence: 99%

Metaproteomic Profile of the Colonic Luminal Microbiota From Patients With Colon Cancer

et al. 2022

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Recent studies have provided evidence of interactions among the gut microbiota (GM), local host immune cells, and intestinal tissues in colon carcinogenesis. However, little is known regarding the functions exerted by the GM in colon cancer (CC), particularly with respect to tumor clinical classification and lymphocyte infiltration. In addition, stool, usually employed as a proxy of the GM, cannot fully represent the original complexity of CC microenvironment. Here, we present a pilot study aimed at characterizing the metaproteome of CC-associated colonic luminal contents and identifying its possible associations with CC clinicopathological features. Colonic luminal contents were collected from 24 CC tissue specimens immediately after surgery. Samples were analyzed by shotgun metaproteomics. Almost 30,000 microbial peptides were quantified in the samples, enabling the achievement of the taxonomic and functional profile of the tumor-associated colonic luminal metaproteome. Upon sample aggregation based on tumor stage, grade, or tumor-infiltrating lymphocytes (TILs), peptide sets enabling discrimination of sample groups were identified through discriminant analysis (DA). As a result, Bifidobacterium and Bacteroides fragilis were significantly enriched in high-stage and high-grade CC, respectively. Among metabolic functions, formate–tetrahydrofolate ligase was significantly associated with high-stage CC. Finally, based on the results of this pilot study, we assessed the optimal sample size for differential metaproteomic studies analyzing colonic luminal contents. In conclusion, we provide a detailed picture of the microbial and host components of the colonic luminal proteome and propose promising associations between GM taxonomic/functional features and CC clinicopathological features. Future studies will be needed to verify the prognostic value of these data and to fully exploit the potential of metaproteomics in enhancing our knowledge concerning CC progression.

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Dysbiosis of human gut microbiome in young-onset colorectal cancer

Cited by 101 publications

References 67 publications

Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions

Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions

Characteristics of Gut Microbiota in Patients With Clear Cell Renal Cell Carcinoma

Metaproteomic Profile of the Colonic Luminal Microbiota From Patients With Colon Cancer

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