Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

Zhang, Jun; Luo, Dan; Zhou, Wenying; Rao, Jialing; Li, Yuanqing; Wu, Jianhao; Peng, Hui; Lou, Tanqi

doi:10.1016/j.micpath.2020.104359

Cited by 38 publications

(47 citation statements)

References 35 publications

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“…Our study builds on those finding by demonstrating a decreased alpha diversity (evenness and richness of taxa) in the INS patients compared to healthy controls. A marked bacterial pattern of INS patients was also a reduction of SCFA-producing bacteria, such as reduced abundance of Romboutsia , Clostridium sensu stricto , Ruminiclostridium , and Lachnospira, which is consistent with the previous report [ 8 ], indicating that a decrease in SCFA-producing bacteria may be the major feature of gut microbiota dysbiosis in both children and adult INS population. In addition to the similar alteration in SCFA-producing bacteria between the children and adult INS population, there are some microbial community changes in the adult INS in the present study.…”

Section: Discussionsupporting

confidence: 91%

“…In keeping with this hypothesis, Zhang et al [ 8 ] recently reported intestinal microbiota dysbiosis in adult MN with INS. However, they did not further study associations between gut microbiota and common clinical characteristics.…”

Section: Introductionmentioning

confidence: 69%

“…Moreover, 4-week initial therapy, including prednisone and compound of vitamin D3 and calcium, could increase the proportion of short-chain fatty acid-(SCFAs-) producing bacteria including Romboutsia, Stomatobaculum, and Cloacibacillus [12]. Zhang et al [8] reported the dysbiosis of intestinal microbiome in adult MN. Our study builds on those finding by demonstrating a decreased alpha diversity (evenness and richness of taxa) in the INS patients compared to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

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Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

Lin

You

et al. 2021

BioMed Research International

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Background. Increasing evidences have reported gut microbiota dysbiosis in many diseases, including chronic kidney disease and pediatric idiopathic nephrotic syndrome (INS). There is lack evidence of intestinal microbiota dysbiosis in adults with INS, however. Here, we to address the association between the gut microbiome and INS. Methods. Stool samples of 35 adult INS patients and 35 healthy volunteers were collected. Total bacterial DNA was extracted, and the V4 regions of the bacterial 16S ribosomal RNA gene were sequenced. The fecal microbiome was analyzed using bioinformatics. The correlation analysis between altered taxa and clinical parameters was also included. Results. We found that microbial diversity in the gut was reduced in adult patients with INS. Acidobacteria, Negativicutes, Selenomonadales, Veillonellaceae, Clostridiaceae, Dialister, Rombousia, Ruminiclostridium, Lachnospira, Alloprevotella, Clostridium sensu stricto, Megamonas, and Phascolarctobacterium were significantly reduced, while Pasteurellales, Parabacteroides, Bilophila, Enterococcus, Eubacterium ventriosum, and Lachnoclostridium were markedly increased in patients with INS. In addition, Burkholderiales, Alcaligenaceae, and Barnesiella were negatively correlated with serum creatinine. Blood urea nitrogen levels were positively correlated with Christensenellaceae, Bacteroidales_S24.7, Ruminococcaceae, Ruminococcus, and Lachnospiraceae_NK4A136, but were negatively correlated with Flavonifractor_plautii and Erysipelatoclostridium_ramosum. Enterobacteriales, Enterobacteriaceae, Porphyromonadaceae, Escherichia/Shigella, Parabacteroides, and Escherichia_coli were positively correlated with albumin. Proteinuria was positively correlated with Verrucomicrobia, Coriobacteriia, Thermoleophilia, Ignavibacteria, Coriobacteriales, Nitrosomonadales, Coriobacteriaceae, and Blautia, but was negatively correlated with Betaproteobacteria, Burkholderiales, and Alcaligenaceae. Conclusion. Our findings show compositional alterations of intestinal microbiota in adult patients with INS and correlations between significantly altered taxa and clinical parameters, which points out the direction for the development of new diagnostics and therapeutic approaches targeted intestinal microbiota.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

Lin

You

et al. 2021

BioMed Research International

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“…Microbial analysis revealed that dysbiosis of the gut microbiome played a key role in the pathogenesis of DKD or MN. These significant differences in gut microbes could provide solid evidence for the classification of DKD and MN, exemplifying the concept of ‘microbial markers’ [ 22 , 33 ]. This study is the first to link the gut microbiome with DKD and MN, and here, we first attempt to use a noninvasive tool based on intestinal flora to distinguish DKD from MN.…”

Section: Discussionmentioning

confidence: 99%

The gut microbiome in differential diagnosis of diabetic kidney disease and membranous nephropathy

Shang

Guo

et al. 2020

Renal Failure

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Background Diabetic kidney disease (DKD) and membranous nephropathy (MN) are the two major causes of end-stage renal disease (ESRD). Increasing evidence has shown that intestinal dysbiosis is associated with many diseases. The aim of this study was to explore the composition of the gut microbiome in DKD and MN patients. Methods 16S rRNA gene sequencing was performed on 271 fecal samples (DKD = 129 and MN = 142), and taxonomic annotation of microbial composition and function was completed. Results We observed distinct microbial communities between the two groups, with MN samples exhibiting more severe dysbiosis than DKD samples. Relative increases in genera producing short-chain fatty acids (SCFAs) in DKD and a higher proportion of potential pathogens in MN were the main contributors to the microbiome alterations in the two groups. Five-fold cross-validation was performed on a random forest model, and four operational taxonomic unit (OTU)-based microbial markers were selected to distinguish DKD from MN. The results showed 92.42% accuracy in the training set and 94.52% accuracy in the testing set, indicating high potential for these microbiome-based markers in separating MN from DKD. Overexpression of several amino acid metabolic pathways, carbohydrate metabolism and lipid metabolism was found in DKD, while interconversion of pentose/glucoronate and membrane transport in relation to ABC transporters and the phosphotransferase system were increased in MN. Conclusion The composition of the gut microbiome appears to differ considerably between patients with DKD and those with MN. Thus, microbiome-based markers could be used as an alternative tool to distinguish DKD and MN.

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“…Meanwhile, The SCFA-producing bacteria Roseburia, Lachnospira, Butyricicoccus, Lactobacillus and the dominant genus associated with SCFAs including Streptococcus [35][36][37] were abundant after naringenin treatment. In addition, the bacteria Lachnospira and Roseburia of butyrate-producing were also more abundant in the naringenin group, and the content of butyric acid, a bene cial substance in the intestine, can prevent and treat obesity-related diseases [38].…”

Section: Discussionmentioning

confidence: 99%

Naringenin, a Flavonoid, Modulates Gut Microbiome and Ameliorates Hormone Levels to Improve Polycystic Ovary Syndrome in Letrozole-induced Rats 

Yang

et al. 2020

Preprint

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Background: Polycystic ovary syndrome (PCOS) is a common female endocrinopathy, which severely affect the menstruation and fertility of patients. Naringenin, a natural flavanone, has emerged as a potential therapeutic agent for the management a variety of diseases. However, the underlying mechanism of naringenin in anti‑PCOS is unclear. This study was focused on investigating the effects of naringenin on body weight, ovarian tissue, serum hormone level, glucose metabolism level and gut microbiome in letrozole-induced PCOS model rats.Methods: First, we administered letrozole gavage to 10-week-old SD female rats for 4 weeks to induce PCOS rats model, the estrus cycle was observed through the vaginal smear of rats to determine the establishment successful of a PCOS rat model. Then, the successfully modeled PCOS rats were treated with naringenin for 2 months. Finally, observed the changes of rat body weight, ovarian tissue, serum hormone level, glucose metabolism level and gut microbiome after naringenin treatment. Results: The naringenin treatment ameliorate the hormone levels, such testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), improve insulin resistance and the ovarian tissue pathological changes, reduced body weight in the PCOS model rat. Meanwhile, through the detection of rDNA in the faeces of the PCOS model rat, we found some beneficial microbes such [Ruminococcus], Faecalibacterium, Butyricimonas, Lachnospira, Parabacteroides, Butyricicoccus and Roseburia were enrichment in naringenin group when compared with the PCOS rats. Conclusions: In summary, our results indicated that naringenin could play an anti-PCOS role, and its mechanism may be closely related to regulating the beneficial microbes of gut microbiome. Our research could provide a new perspective for the treatment of PCOS and its related disease.

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Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

Cited by 38 publications

References 35 publications

Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

The gut microbiome in differential diagnosis of diabetic kidney disease and membranous nephropathy

Naringenin, a Flavonoid, Modulates Gut Microbiome and Ameliorates Hormone Levels to Improve Polycystic Ovary Syndrome in Letrozole-induced Rats

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Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

Cited by 38 publications

References 35 publications

Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

Gut Microbiota Profile in Adult Patients with Idiopathic Nephrotic Syndrome

The gut microbiome in differential diagnosis of diabetic kidney disease and membranous nephropathy

Naringenin, a Flavonoid, Modulates Gut Microbiome and Ameliorates Hormone Levels to Improve Polycystic Ovary Syndrome in Letrozole-induced Rats&nbsp;

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Naringenin, a Flavonoid, Modulates Gut Microbiome and Ameliorates Hormone Levels to Improve Polycystic Ovary Syndrome in Letrozole-induced Rats