Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

Sinha, S.; Nguyen, Linh P.; Tropini, Carolina; Haileselassie, Yeneneh; Becker, Laren; Sim, Davis; Bittinger, Kyle; Sonnenburg, Justin L.; Habtezion, Aida

doi:10.2139/ssrn.3305552

Cited by 8 publications

(11 citation statements)

References 44 publications

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“…Moreover, Sinha et al [58] confirmed that the family Ruminococcaceae is positively correlated with the SBA concentration and that a reduced relative abundance of Ruminococcaceae results in SBA deficiency. In this study, we observed that the SBAs in the HFD + MN002 group were the highest and that the PBA/SBA ratio was the lowest.…”

Section: Discussionmentioning

confidence: 96%

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002

et al. 2022

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Section: Discussionmentioning

confidence: 96%

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002

et al. 2022

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“…The microbiota interacts with the host mainly through bacterial components and microbial metabolites, such as short-chain fatty acids (SCFAs), secondary bile acids, and tryptophan. Recent research has provided a better mechanistic understanding of this, demonstrating that dysbiosis-related secondary bile acid deficiency may lead to inflammation, and supplementation can improve this [83]. Related to the microbiome, nutrigenomics is another important area of ongoing research.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases

et al. 2021

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Despite being a focal issue to patients, the effect of diet on adult inflammatory bowel disease (IBD) remains underexplored with limited guidance. While promising clinical trials are currently underway, there is a need for further evidence-based recommendations. As such, we summarize the current evidence on various diets used in the treatment of IBD and also explore the potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis and psoriasis, to provide additional information to inform IBD providers. To date, there have been multiple diets investigated as adjunctive therapy in IBD, but many associated studies are small, non-randomized, and not controlled. Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets have been studied and have shown some positive results in other IMIDs, which may suggest potential applicability to those with IBD, but larger, well-designed clinical trials are needed for further guidance. Gluten-free and low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP)diets do not appear to have an impact on IBD disease activity, but low FODMAP may potentially be helpful for those with concurrent functional gastrointestinal symptoms. Specific carbohydrate diets have been mainly assessed in children but show some potential in small adult studies.

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“…Mientras que algunos estudios reportan que la microbiota de pacientes con colitis ulcerosa se encuentra reducido en el filo Firmicutes y aumentado en el filo Bacteroidetes y la familia Enterobacteriaceae (46)(47)(48)(49)(50), otros estudios observaron lo contrario (45,51). Cabe destacar que la presencia de algunas especies bacterianas como Akkermansia muciniphila, Butyricicoccus pullicaecorum, Faecalibacterium prausnitzii, el género Roseburia, y la familia Ruminococcaceae se encuentran claramente disminuidas en la microbiota de pacientes con colitis ulcerosa (50,52,53), mientras que especies de las familias Clostridiaceae y Enterococcaceae se encuentran aumentadas en estos individuos(53) (Figura 1).…”

Section: Papel De La Microbiota Intestinal En La Enfermedad Inflamato...unclassified

Probióticos para el tratamiento de la Colitis Ulcerosa y la Enfermedad de Crohn

Aliaga¹,

Delgado-Diaz²

2022

Preprint

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Inflammatory bowel disease is a chronic disease that affects the gastrointestinal tract and which incidence is on the rise in Latin America. Although the aetiology of the disease has not yet been fully elucidated, it is known that this disease is associated with imbalances in the intestinal microbiota, among other factors. Due to the potential of probiotics to modulate the intestinal microbiota, the effect of probiotics in the treatment of this condition has been studied. Here, we describe the types of inflammatory bowel diseases and their relationship with the gut microbiota composition. Likewise, we analysed clinical studies focused on the treatment of inflammatory bowel disease with various types of probiotics and determined that these studies lack sufficient clinical evidence to approve and recommend their use in patients suffering from inflammatory bowel disease. Studies of higher quality and statistical power should be prioritized to clarify the benefit of probiotics in inflammatory bowel disease.

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Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

Cited by 8 publications

References 44 publications

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002

Influence of high-fat diet on host animal health via bile acid metabolism and benefits of oral-fed <i>Streptococcus thermophilus</i> MN-ZLW-002

Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases

Probióticos para el tratamiento de la Colitis Ulcerosa y la Enfermedad de Crohn

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