Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)

Pinto, Serge; Cardoso, Rita; Sadat, Jasmin; Guimarães, Isabel; Mercier, Céline; Santos, Helena; Atkinson-Clément, Cyril; Carvalho, Joana; Welby, Pauline; Oliveira, Pedro; D’Imperio, Mariapaola; Frota, Sónia; Letanneux, Alban; Vigário, Marina; Cruz, Marisa; Martins, Isabel Pavão; Viallet, François; Ferreira, Joaquim J.

doi:10.1136/bmjopen-2016-012885

Cited by 21 publications

(19 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Orofacial rhythmic abilities were tested with an oral diadochokinesis task (repetition of a pseudoword at a fast rate for 30 s), 38 providing measures of orofacial motor control, irrespective of speech dimensions, such as intonation or phonetic components. Patients repeated the three-syllable pseudoword pataka ; their productions were acquired with a suitable digital recorder (Zoom H4SP © ).…”

Section: Methodsmentioning

confidence: 99%

Heightened orofacial, manual, and gait variability in Parkinson’s disease results from a general rhythmic impairment

Puyjarinet¹,

Bégel²,

Gény³

et al. 2019

npj Parkinsons Dis.

Self Cite

View full text Add to dashboard Cite

Individuals with Parkinson’s disease (PD) experience rhythm disorders in a number of motor tasks, such as (i) oral diadochokinesis, (ii) finger tapping, and (iii) gait. These common motor deficits may be signs of “general dysrhythmia”, a central disorder spanning across effectors and tasks, and potentially sharing the same neural substrate. However, to date, little is known about the relationship between rhythm impairments across domains and effectors. To test this hypothesis, we assessed whether rhythmic disturbances in three different domains (i.e., orofacial, manual, and gait) can be related in PD. Moreover, we investigated whether rhythmic motor performance across these domains can be predicted by rhythm perception, a measure of central rhythmic processing not confounded with motor output. Twenty-two PD patients (mean age: 69.5 ± 5.44) participated in the study. They underwent neurological and neuropsychological assessments, and they performed three rhythmic motor tasks. For oral diadochokinesia, participants had to repeatedly produce a trisyllable pseudoword. For gait, they walked along a computerized walkway. For the manual task, patients had to repeatedly produce finger taps. The first two rhythmic motor tasks were unpaced, and the manual tapping task was performed both without a pacing stimulus and musically paced. Rhythm perception was also tested. We observed that rhythmic variability of motor performances (inter-syllable, inter-tap, and inter-stride time error) was related between the three functions. Moreover, rhythmic performance was predicted by rhythm perception abilities, as demonstrated with a logistic regression model. Hence, rhythm impairments in different motor domains are found to be related in PD and may be underpinned by a common impaired central rhythm mechanism, revealed by a deficit in rhythm perception. These results may provide a novel perspective on how interpret the effects of rhythm-based interventions in PD, within and across motor domains.

show abstract

Section: Methodsmentioning

confidence: 99%

Heightened orofacial, manual, and gait variability in Parkinson’s disease results from a general rhythmic impairment

Puyjarinet¹,

Bégel²,

Gény³

et al. 2019

npj Parkinsons Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

“…As noted above, the effects of levodopa on speech prosody seem inconclusive, depending on the measure and the task, among other factors. The effects of long-term use of medication are also inconclusive and complex, with some studies reporting beneficial effects mostly in the early years of the disease and others in more advanced patients with PD [39,57,58]. The lack of effectiveness of levodopa and the severity of the disease may result in motor fluctuations, which also affect speech [59].…”

Section: Dopaminergic Treatment Disease Duration and Prosodymentioning

confidence: 99%

“…Thirty patients with idiopathic Parkinson's disease (15 male, 15 female) aged between 40 and 82 years participated in the study, together with 20 healthy controls age-and gendermatched (Table 1). The participants were part of a larger pool of participants studied within the FraLusoPark project and recruited at the Movement Disorders Unit, Hospital de Santa Maria, Lisbon, and Campus Neurológico Sénior (CNS), Torres Vedras, Portugal [57]. For the current study, inclusion and exclusion criteria were as follows: the diagnosis of idiopathic PD (according to the UK Parkinson's Disease Brain Bank Criteria [61]) for patients, and the absence of any neurological, psychiatric, or behavioral pathology for controls.…”

Section: Participants and Assessmentsmentioning

confidence: 99%

(Dys)Prosody in Parkinson’s Disease: Effects of Medication and Disease Duration on Intonation and Prosodic Phrasing

Frota

Cruz

Cardoso³

et al. 2021

Brain Sciences

Self Cite

View full text Add to dashboard Cite

The phonology of prosody has received little attention in studies of motor speech disorders. The present study investigates the phonology of intonation (nuclear contours) and speech chunking (prosodic phrasing) in Parkinson’s disease (PD) as a function of medication intake and duration of the disease. Following methods of the prosodic and intonational phonology frameworks, we examined the ability of 30 PD patients to use intonation categories and prosodic phrasing structures in ways similar to 20 healthy controls to convey similar meanings. Speech data from PD patients were collected before and after a dopaminomimetic drug intake and were phonologically analyzed in relation to nuclear contours and intonational phrasing. Besides medication, disease duration and the presence of motor fluctuations were also factors included in the analyses. Overall, PD patients showed a decreased ability to use nuclear contours and prosodic phrasing. Medication improved intonation regardless of disease duration but did not help with dysprosodic phrasing. In turn, disease duration and motor fluctuations affected phrasing patterns but had no impact on intonation. Our study demonstrated that the phonology of prosody is impaired in PD, and prosodic categories and structures may be differently affected, with implications for the understanding of PD neurophysiology and therapy.

show abstract

“…These results are relevant because the fact that translations of this particular text are available for a great number of languages makes it an evident choice for work in many areas where the comparison across languages is useful. The same text was chosen, for example, in an ongoing project that involves, among other things, comparing the performance of two large groups of patients in different stages of Parkinson's disease, speaking French and Portuguese, respectively, in a reading-aloud task (Pinto et al 2016).…”

Section: Recent Applicationsmentioning

confidence: 99%

Basic research in phonology, resources and applications–the case of frequency

et al. 2017

Self Cite

View full text Add to dashboard Cite

É crescente a valorização da conversão do conhecimento fundamental desenvolvido pelos cientistas em produtos concretos, socialmente relevantes. No Laboratório de Fonética da Universidade de Lisboa tem-se trabalhado nos últimos anos tanto em domínios de investigação fundamental, como de investigação aplicada. Neste artigo é feita uma revisão dos principais recursos recentemente disponibilizados à comunidade por este Laboratório visando o acesso a informação sobre frequência fonológica e lexical. São sumariamente apresentados, em particular, as aplicações informáticas para extração de informação de frequência fonológica e lexical FreP (V2016) e FreLex, a base de dados alargada FrePOP (agora sobre um corpus de cerca de 2 milhões de palavras), e 3 novos léxicos, o FrePOP Lexicon (frequência lexical num corpus de 3 milhões de palavras), o PLEX5 – Um léxico Infantil para o Português Europeu e o CDS_EP – Frequência lexical nos dados de fala dirigida à criança da FrePOP (0;11 a 3;04 ). São ainda revistos estudos recentes que fizeram uso destes recursos, ilustrando a sua utilidade em domínios de investigação fundamental e aplicada.

show abstract

Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)

Cited by 21 publications

References 66 publications

Heightened orofacial, manual, and gait variability in Parkinson’s disease results from a general rhythmic impairment

Heightened orofacial, manual, and gait variability in Parkinson’s disease results from a general rhythmic impairment

(Dys)Prosody in Parkinson’s Disease: Effects of Medication and Disease Duration on Intonation and Prosodic Phrasing

Basic research in phonology, resources and applications–the case of frequency

Contact Info

Product

Resources

About