Dynapenic obesity and the risk of incident Type 2 diabetes: the English Longitudinal Study of Ageing

Cuthbertson, Daniel J.; Bell, Joshua A.; Ng, Sarah; Kemp, Graham J.; Kivimäki, Mika; Hamer, Mark

doi:10.1111/dme.12991

Cited by 62 publications

(58 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, these conditions reduce functioning abilities [20]. In a longitudinal study by Cuthbertson et al, a relationship was observed between dynapenic obesity with a high BMI score and low muscular strength and diabetes in elderly people [3].…”

Section: Discussionmentioning

confidence: 98%

“…The number of studies on diabetes also increased in Iran, and most of these studies emphasize the outcomes, management, and genetic causes of diabetes [2]. Overweight and obesity are among the main important factors that are associated with type 2 diabetes, and several studies showed that a significant portion of patients with diabetes are also overweight or obese [3,4]. However, recently, the obesity paradox, which addresses the lower rate of mortality in patients with diabetes [5], is one of the most controversial topics evaluated in a meta-analysis on [20] studies, and more than 250,000 patients showed the positive effect of overweight on the survival rate of patients with diabetes among all age groups and the positive effects of obesity on the survival rate of elderly people with diabetes [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study

Bijani

Cumming

Hosseini

et al. 2018

J Diabetes Metab Disord

View full text Add to dashboard Cite

Background and objectives Overweight and obesity are among the important challenges in health issues and survival of elderly people. The current study aimed to evaluate the survival rate of elderly patients with diabetes, and its influencing factors, on the basis of body mass index (BMI). Methods and materialsThe design of the current study was based on the Amirkola Health and Aging Project (AHAP) cohort.The 5-year survival rate of elderly people with diabetes and the factors that influence the mortality rate by Cox regression model were analyzed. Results Out of 1616 elderly people who were evaluated in the current study, 501 (31%) had diabetes. The results showed that diabetes significantly increased the mortality rate (adjusted hazard ratio [HR] = 2.10; 95% confidence interval [CI]: 1.57-2.81; P < 0.001). Furthermore, overweight (HR = 0.41; 95%CI: 0.24-0.75; P = 0.002), obesity (HR = 0.30; 95% CI: 0.41-0.63; P = 0.002), history of diabetes (HR = 0.56; 95%CI: 0.34-0.93; P = 0.024), moderate and high physical activity level (HR = 0.36; 95%CI: 0.13-0.99; P = 0.049) decreased the risk of mortality and central obesity (HR = 1.76; 95% CI: 1.01-3.11; P = 0.049), fasting blood sugar ≥200 (HR = 2.46; 95% CI: 1.46-4.15; P < 0.001), brain stroke, and neurological diseases (HR = 3.12; 95% CI: 1.78-5.49; P < 0.001) increased the risk of mortality. Conclusion Although overweight and obesity significantly improved the risk of mortality in elderly patients with diabetes, central obesity is still considered as an important risk factor.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study

Bijani

Cumming

Hosseini

et al. 2018

J Diabetes Metab Disord

View full text Add to dashboard Cite

show abstract

“…We calculated the mean of the maximum handgrip strength from both hands. We used handgrip strength as an index of muscle quality (Hamer et al 2015;Cuthbertson et al 2016). To investigate the effect of muscle strength on cognitive dysfunction risk, we divided the participants into four groups based on sexspecific categories (Janssen et al 2002;An and Kim 2016): low (< mean value minus one standard deviation [SD]), normal-low (mean value minus one SD to < mean value), normal-high (mean value to < mean value plus one SD), and high (≥ mean value plus one SD).…”

Section: Muscular Strengthmentioning

confidence: 99%

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Jeong

Kim

2018

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Dementia is one of the priority public health problems in the older population, and the number of people with dementia is steadily increasing. The longitudinal association of muscle strength with risk of new-onset cognitive dysfunction in a general population including middle and older adults remains unknown. The purpose of this study was to investigate the effects of low muscle strength on risk for new-onset cognitive dysfunction over 6 years using a large nationwide sample of cognitively healthy adults. Study participants included 6,435 middle and older adults (33,554 person-years of follow-up), using data from the Korean Longitudinal Study of Ageing 2006-2012. Muscular strength was measured using the maximum handgrip strength of each participant as an index of muscle quality. Low muscle strength was defined as one standard deviation below the mean using the handgrip strength index based on the study population. Cognitive function was evaluated using the Mini-Mental Status Evaluation. The hazard ratio (HR) for cognitive dysfunction significantly and linearly increased according to muscle strength status independent of potential confounding factors (HR: 1.36, 95% confidence interval [CI]: 1.18-1.56 for low vs. normal-high group). Using stratified analyses, a significant association between muscle strength status and risk of cognitive impairment was observed in those with low physical activity, but not those with high physical activity. We show that handgrip strength is associated with increased risk of new-onset cognitive dysfunction over 6 years of follow-up in cognitively healthy middle aged and older adults at baseline.

show abstract

“…However, results regarding older adults’ mortality and the presence of sarcopenic/dynapenic obesity are not always homogeneous, probably because many risk factors should be considered, such as the presence of chronic diseases (CD), that plays an important role in inflammatory response, oxidative stress and metabolic pathways …”

Section: Introductionmentioning

confidence: 99%

Association of dynapenia, obesity and chronic diseases with all‐cause mortality of community‐dwelling older adults: A path analysis

Komatsu

Borim

Néri

et al. 2018

Geriatrics Gerontology Int

View full text Add to dashboard Cite

Aim The objective of the present study was to evaluate the effect of dynapenia, central obesity and the presence of chronic diseases in 8‐year mortality of community‐dwelling older adults. Methods Participants comprised 610 older adults, aged ≥65 years at baseline, who participated in the “Frailty in Brazilian Older People” study carried out in 2008. Baseline data, such as weight, height, waist circumference, muscle strength, sex, self‐reported diseases and physical activity, were assessed. Vital status in 2016 was assessed by Mortality Information System database of Campinas. The χ2‐test and Mann–Whitney U‐test were used to compare categorical and continuous variables, respectively. Path analysis was carried out to study the factors associated with mortality. Results There was a statistical difference between alive and deceased groups for the variables sex, age group, physical activity, waist circumference and dynapenia. Path analysis explored the relationship among the studied variables. Direct paths showed a positive association to mortality for those who presented the combination of more diseases (β = 0.105), male sex (β = 0.108), low physical activity (β = 0.121), low handgrip strength (β = 0.090) and no central obesity (β = −0.143). When indirect paths were concerned, variables “central obesity”, the presence of “more diseases” and dynapenia had a mediator role. Conclusions Central obesity was not positively associated with higher mortality, unless it was associated with the presence of chronic diseases. Dynapenia showed a direct effect on mortality, but not combined with central obesity. The findings of this study shed light on complex relationships between nutritional status and elderly mortality through the use of simple measurements. Geriatr Gerontol Int 2019; 19: 108–112.

show abstract

Dynapenic obesity and the risk of incident Type 2 diabetes: the English Longitudinal Study of Ageing

Abstract: 26

Cited by 62 publications

References 29 publications

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Association of dynapenia, obesity and chronic diseases with all‐cause mortality of community‐dwelling older adults: A path analysis

Contact Info

Product

Resources

About