Dynapenia and diaphragm muscle dysfunction in patients with heart failure

Kinugasa, Yoshiharu; Miyagi, Mari; Sota, Takeshi; Yamada, Kensaku; Ishisugi, Takuya; Hirai, Masayuki; Yanagihara, Kiyotaka; Haruki, Nobuhiko; Matsubara, Koichi; Kato, Masahiko; Yamamoto, Kazuhide

doi:10.1177/2047487318793212

Cited by 8 publications

(8 citation statements)

References 2 publications

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“…1 Malnutrition is related to muscle loss and weakness, leading to physical frailty and poor prognosis in HF. 4 Minimising polypharmacy is likely to be a key action to recover EI and to maintain nutritional status in patients with HF.…”

mentioning

confidence: 99%

Polypharmacy and taste disorders in heart failure patients

Kinugasa

Nakayama

Sugihara

et al. 2019

Eur J Prev Cardiolog

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mentioning

confidence: 99%

Polypharmacy and taste disorders in heart failure patients

Kinugasa

Nakayama

Sugihara

et al. 2019

Eur J Prev Cardiolog

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“…Patients with heart failure often develop muscle atrophy and www.e-arm.org changes in total muscle mass [33]. However, Kinugasa et al [34] found that 40.3% of patients with heart failure had muscle weakness despite normal muscle mass. In addition, it has been suggested that muscle atrophy develops only secondary to inactivity in patients with heart failure [33].…”

Section: Discussionmentioning

confidence: 99%

Phase Angle Is Associated With Handgrip Strength in Older Patients With Heart Failure

Kawakami¹,

Umehara²,

Iwamoto³

et al. 2023

Ann Rehabil Med

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Objective To assess the relationships between phase angle and muscle mass, strength, and physical function in patients with heart failure. Methods This study used a cross-sectional design. The analysis included 51 patients with heart failure. The Short Physical Performance Battery, one-leg standing time, handgrip strength, phase angle, and skeletal muscle index were measured. To identify explanatory variables of phase angle, hierarchical multiple regression analysis was performed.Results Handgrip strength was found to be an explanatory variable of phase angle independent of age, sex, and body mass index. This model was able to explain 30.4% of the model variance for phase angle. ConclusionIn patients with heart failure, improving muscle strength rather than muscle mass or physical function might be more important for improving phase angle. Handgrip strength is an important outcome for improving prognosis in patients with heart failure.

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“…Skeletal muscle weakness was classified into two phenotypes as shown in Figure S1(b): sarcopenia (low muscle strength with low muscle mass) and dynapenia (low muscle strength with normal muscle mass). Low muscle mass and low muscle strength were defined according to previously described criteria 20 . Low muscle mass was defined as an SMI of <7.0 kg/m 2 for men and <5.7 kg/m 2 for women, and low muscle strength was defined as a handgrip strength of <28 kg for men and <18 kg for women.…”

Section: Methodsmentioning

confidence: 99%

“…Low muscle mass and low muscle strength were defined according to previously described criteria. 20 Low muscle mass was defined as an SMI of <7.0 kg/m 2 for men and <5.7 kg/m 2 for women, and low muscle strength was defined as a handgrip strength of <28 kg for men and <18 kg for women.…”

Section: Sarcopenia and Dynapeniamentioning

confidence: 99%

Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure

Kinugasa

Sota

Nakamura

et al. 2023

Geriatrics Gerontology Int

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Aim L‐carnitine transports fatty acids into mitochondria and contributes to energy metabolism in skeletal muscles. However, the association between carnitine insufficiency and skeletal muscle weakness, namely sarcopenia and dynapenia, in patients with heart failure (HF) remains unclear. Methods In total, 124 patients with HF were enrolled in this study. Carnitine insufficiency was indicated by a decrease in serum free carnitine (FC) levels of less than 36 μmol/L or an elevated serum acylcarnitine (AC) to free carnitine (FC) ratio (AC/FC ratio) of 0.27 or higher. Skeletal muscle weakness was defined as reduced handgrip strength and classified into two phenotypes: sarcopenia (low muscle strength with low skeletal muscle mass) and dynapenia (low muscle strength with normal skeletal muscle mass). Results Patients with carnitine insufficiency had a significantly higher prevalence of muscle weakness and a lower 6‐min walk distance than those without carnitine insufficiency (P < 0.05). A machine learning model showed that older age (≥77 years) and, in patients aged 64–76 years, a higher AC/FC ratio (≥0.31) were associated with sarcopenia. However, there was only a week association between carnitine levels and dynapenia. The effect of carnitine insufficiency on skeletal muscle weakness was greater in patients with low skeletal muscle mass than in those with normal skeletal muscle mass (P < 0.05 for interaction). Conclusions Carnitine insufficiency is more closely associated with sarcopenia than with dynapenia in patients with HF, suggesting carnitine insufficiency as a potential therapeutic target for sarcopenia in these patients. Geriatr Gerontol Int 2023; 23: 524–530.

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Dynapenia and diaphragm muscle dysfunction in patients with heart failure

Cited by 8 publications

References 2 publications

Polypharmacy and taste disorders in heart failure patients

Polypharmacy and taste disorders in heart failure patients

Phase Angle Is Associated With Handgrip Strength in Older Patients With Heart Failure

Association of carnitine insufficiency with sarcopenia and dynapenia in patients with heart failure

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