Dynamin-1 is a potential mediator in Cancer-Related Cognitive Impairment
Ding Quan Ng,
Casey Hudson,
Tracy Nguyen
et al.
Abstract:Dynamin-1 (DNM1) consolidates memory through synaptic transmission and modulation and has been explored as a therapeutic target in Alzheimer’s disease. Through a two-prong approach, this study examined its role in cancer-related cognitive impairment (CRCI) pathogenesis using human and animal models. The human study recruited newly diagnosed, chemotherapy-naïve adolescent and young adult cancer and non-cancer controls to complete a cognitive instrument (FACT-Cog) and blood draws for up to three time points. Con… Show more
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