Dynamics of Thiocyanate Dialyses

Danzig, Lamont E.

doi:10.1056/nejm195501132520203

Cited by 23 publications

(2 citation statements)

References 18 publications

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“…In experimental animals, approximately 60-90 % of incurred cyanide is converted to SCN -(14247659). Thiocyanate excretion in humans occurs at a uniformly slow rate [6]; mainly because about 90 % of SCN -fi ltered by kidneys is reabsorbed [7]. A common side-effect of SCN -treatments introduced in the 1930s to counteract hypertension was iatrogenic eosinophilia [8].…”

Section: Resultsmentioning

confidence: 99%

Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and ‘histamine dysmetabolism’

Smith

Garrett

2008

Inflamm. res.

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Section: Resultsmentioning

confidence: 99%

Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and ‘histamine dysmetabolism’

Smith

Garrett

2008

Inflamm. res.

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“…Like vitamins, SCN − or its precursor is normally obtained by humans only from food 57 ; it is excreted in the urine 57 , 58 . Cruciferous vegetables, such as broccoli and cabbages, contain glucosinolates that can be hydrolyzed to yield SCN − 57 .…”

Section: Discussionmentioning

confidence: 99%

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice

Yamakaze

Lü

2021

Sci Rep

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Strongly oxidative H2O2 is biologically important, but if uncontrolled, would lead to tissue injuries. Lactoperoxidase (LPO) catalyzes the redox reaction of reducing highly reactive H2O2 to H2O while oxidizing thiocyanate (SCN−) to relatively tissue-innocuous hypothiocyanite (OSCN−). SCN− is the only known natural, effective reducing-substrate of LPO; humans normally derive SCN− solely from food. While its enzymatic mechanism is understood, the actual biological role of the LPO-SCN− system in mammals remains unestablished. Our group previously showed that this system protected cultured human cells from H2O2-caused injuries, a basis for the hypothesis that general deficiency of such an antioxidative mechanism would lead to multisystem inflammation and tumors. To test this hypothesis, we globally deleted the Lpo gene in mice. The mutant mice exhibited inflammation and lesions in the cardiovascular, respiratory, digestive or excretory systems, neuropathology, and tumors, with high incidence. Thus, this understudied LPO-SCN− system is an essential protective mechanism in vivo.

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Treatment of Malignant Hypertension With Sodium Nitroprusside

Ahearn¹

1974

Arch Intern Med

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Dynamics of Thiocyanate Dialyses

Cited by 23 publications

References 18 publications

Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and ‘histamine dysmetabolism’

Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and ‘histamine dysmetabolism’

Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice

Treatment of Malignant Hypertension With Sodium Nitroprusside

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