Dynamics of supercritical extraction of biological active substances from the Juniperus communis var. saxatillis

Selective extraction of terpenoid compounds of Juniperus communis L. wood in the medium of a binary solvent (supercritical CO2 with modifier)

“…This makes the effective extraction of biomass components possible. Thus, supercritical fluid extraction (SCE) with carbon dioxide (CO 2 ) is of great interest for the development of modern methods of extraction as an environmentally friendly method that provides soft extraction of BASs . The binary solvent (supercritical CO 2 with a solvent having affinity to the extractives, for example, ethanol) is often used for the improvement of extraction efficiency.…”

“…This is probably due to the presence of chemical compounds that perform a protective function, such as terpenes, in its composition. It was shown that the extracts of Juniperus communis contain almost all classes of terpenes with antioxidant and antimicrobial effects . As a rule, the majority of studies are devoted to the investigation of the chemical composition of extracts and essential oils of juniper wood greenery and galberries, and their biological activity .…”

“…It was shown that the extracts of Juniperus communis contain almost all classes of terpenes with antioxidant and antimicrobial effects . As a rule, the majority of studies are devoted to the investigation of the chemical composition of extracts and essential oils of juniper wood greenery and galberries, and their biological activity . In comparison, far fewer studies are devoted to the investigation of wood extractives; moreover they usually relate to the extraction of BASs with organic solvents in a Soxhlet apparatus .…”

Artemisia annua organic solvent extract, processed by supercritical CO2

“…However, vegetable matter has a very complex structure and composition, and the organic solvents, as a rule, extract numerous compound families showing a limited selectivity towards the compound/s of interest. For these reasons, alternative extraction processes have been proposed in the scientific literature and, in some cases, on the industrial scale, that are based on the use of supercritical carbon dioxide (SC‐CO 2 ) …”

“…For these reasons, alternative extraction processes have been proposed in the scientific literature and, in some cases, on the industrial scale, that are based on the use of supercritical carbon dioxide (SC-CO 2 ). [1][2][3][4][5][6][7] In the specific case of Artemisia annua L., the extract contains artemisinin, a sesquiterpene lactone, and its derivatives (mainly artemisin and dehydroartemisinin) that show a strong antimalaric activity, particularly against drug resistant strains of Plasmodium falciparum. It has also been demonstrated that these extracts are antifibrotic 8 and have a potent cytotoxic activity against some kinds of tumor.…”