Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc
Libangxi Liu,
Hong Sun,
Yang Zhang
et al.
Abstract:BackgroundThe N6‐methyladenosine (m6A) dynamics in the progression of intervertebral disc (IVD) aging remain largely unknown. This study aimed to explore the distribution and pattern of m6A modification in nucleus pulpous (NP) tissues of rats at different ages.MethodsHistological staining and MRI were performed to evaluate the degeneration of IVD. The expression of m6A modifiers was analyzed using qRT‐PCR and western blot. Subsequently, methylated RNA immunoprecipitation next generation sequencing and RNA‐seq … Show more
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