Dynamics of SARS-CoV-2 lineages in French Guiana in 2020–2021: 4 epidemic waves with cross-influences from Europe and South America

Miliu, Alexandra; Lee, Anne; Succo, Tiphanie; Laizé, Claire; Andrieu, Audrey; Enfissi, Antoine; Enouf, Vincent; Werf, Sylvie van der; Blanchet, Denis; Demar, Magalie; Carod, Jean-François; Carage, Thierry; Flamand, Claude; Tirera, Sourakhata; Simon‐Lorière, Etienne; Rousseau, Cyril; Rousset, Dominique

doi:10.1016/j.meegid.2022.105370

Cited by 3 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The waves’ dates were defined by the local sanitary authority according to epidemiological data on the responsible strain [ 1 ]. In our study, we classified the four epidemic waves in three periods as follows: Period 1 (Waves 1 and 2): from May to September 2020, and from November 2020 to February 2021 caused by the original SARS-CoV-2 strain.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Matheus,

Houcke,

Lontsi Ngoulla

et al. 2024

TropicalMed

Self Cite

View full text Add to dashboard Cite

(1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) Methods: We conducted a prospective, observational, and non-interventional study in ICU at Cayenne Hospital. We included 383 patients older than 18 admitted with SARS-CoV-2-related pneumonia hospitalized from May 2020 to December 2021. The study covers three periods. Period 1 (Waves 1 and 2, original variant), period 2 (Wave 3, Gamma variant), and period 3 (Wave 4, Delta variant). (3) Results: The median age was 63 years (52–70). Frailty was diagnosed in 36 patients over 70 (32.4%). Only 4.8% of patients were vaccinated. The median ICU LOS was 10 days (6–19). Hospital mortality was 37.3%. It was 30.9% in period 1, 36.6% in period 2 (p = 0.329 vs. period 1), and 47.1% in period 3 (0.015 vs. period 1). In multivariate analysis, independent factors associated with hospital mortality included age greater than 40 years (]40–60 years] OR = 5.2, 95%CI: 1.4–19.5; (]60–70 years] OR = 8.5, 95%CI: 2.2–32; (]70+ years] OR = 17.9, 95%CI: 4.5–70.9), frailty (OR = 5.6, 95%CI: 2.2–17.2), immunosuppression (OR = 2.6, 95%CI: 1.05–6.7), and MV use (OR = 11, 95%CI: 6.1–19.9). This model had an overall sensitivity of 72%, a specificity of 80.4%, a positive predictive value of 68.7%, and a negative predictive value of 82.8%. (4) Conclusions: The mortality of severe COVID-19 patients in French Amazonia was higher during the Delta variant wave. This over-death could be explained by the virulence of the responsible SARS-CoV-2 variant and the under-vaccination coverage of the studied population.

show abstract

Section: Methodsmentioning

confidence: 99%

“…SARS-CoV-2 waves in FG were declared when the incidence density in the community exceeded a threshold of 150 infected cases/100,000 inhabitants or when the dominant variant changed [ 1 ]. Accordingly, patients’ characteristics and outcomes can vary from wave to wave.…”

Section: Introductionmentioning

confidence: 99%

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Matheus,

Houcke,

Lontsi Ngoulla

et al. 2024

TropicalMed

Self Cite

View full text Add to dashboard Cite

show abstract

“…The waves' dates were defined by the local sanitary authority according to epidemiological data on the responsible strain [1]. In our study, we classified the four epidemic waves in three periods as follows: We calculated the weekly occupancy rates (WOR), defined as the number of hospitalized patients (COVID and non-COVID) divided by the number of ICU bed capacity during the considered week (cumulative number of daily open beds during the week).…”

Section: Methodsmentioning

confidence: 99%

“…2 SARS-CoV-2 waves in FG were declared when the incidence density in the community exceeded a threshold of 150 infected cases/100,000 inhabitants or when the dominant variant changed [1]. Accordingly, patients' characteristics and outcomes can vary from wave to wave.…”

Section: Introductionmentioning

confidence: 99%

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Matheus,

Houcke,

Lontsingoula

et al. 2023

Preprint

View full text Add to dashboard Cite

(1) Background: Until December 2021, French Guiana (FG), located in South America, faced four consecutive COVID-19 epidemic waves. This study sought to analyze the mortality trend of severe COVID-19 patients admitted to the referral ICU of FG. (2) Methods: We conducted a prospective, observational, and non-interventional study in ICU at Cayenne Hospital. We included 383 patients older than 18 admitted with SARS-CoV-2-related pneumonia hospitalized from May 2020 to December 2021. The study covers three periods. Period 1 (Waves 1 and 2, original variant), period 2 (Wave 3, gamma variant), and period 3 (Wave 4, delta variant). (3) Results: The median age was 63 years (52-70). Frailty was diagnosed in 36 patients over 70 (32.4%). Only 4.8% of patients were vaccinated. The median ICU LOS was 10 days (6-19). Hospital mortality was 37.3%. It was 30.9% in period 1, 36.6% in period 2 (p=0.329 vs. period 1), and 47.1% in period 3 (0.015 vs. period 1). In multivariate analysis, independent factors associated with hospital mortality were age more than 40 years (]40-60 years] OR=5.2, 95%CI: 1.4-19.5; (]60-70 years] OR=8.5 95%CI: 2.2-32; (]70+ years] OR=17.9, 95%CI: 4.5-70.9), frailty (OR=5.6, 95%CI: 2.2-17.2), immunosuppression (OR=2.6, 95%CI: 1.05-6.7), and MV use (OR=11, 95%CI: 6.1-19.9). This model had an overall sensitivity of 72%, a specificity of 80.4%, a positive predictive value of 68.7%, and a negative predictive value of 82.8%. (4) Conclusions: The mortality of severe COVID-19 patients in French Amazonia was higher during the delta variant wave. This over-death is explained by the virulence of the responsible SARS-CoV-2 variant and the under-vaccination coverage of the studied population.

show abstract

“…Six vagues épidémiques se sont succédé jusqu’à fin 2022 au gré des importations de variants et des vagues de l'environnement latino-américain [ 234 , 331 ] (Fig. 14 ).…”

Section: Pathologies Infectieuses Fébrilesunclassified

Panorama des pathologies infectieuses et non infectieuses de Guyane en 2022

EPELBOIN,

ABBOUD,

ABDELMOUMEN

et al. 2023

Mtsi

Self Cite

View full text Add to dashboard Cite

Résumé Source de nombreux mythes, la Guyane représente un territoire exceptionnel par la richesse de sa biodiversité et par la variété des communautés qui la composent. Seul territoire européen en Amazonie, entouré du géant brésilien et du méconnu Suriname, on y lance des fusées Ariane 6 depuis Kourou tandis que 50% de la population vit en dessous du seuil de pauvreté. Cette situation paradoxale est source de problématiques de santé spécifiques à ce territoire, qu'il s'agisse de maladies infectieuses à germes méconnus, d'intoxications, ou de pathologies chroniques. Certaines maladies infectieuses telles que la fièvre Q, la toxoplasmose, la cryptococcose ou l'infection à VIH sont communes aux pays tempérés, mais présentent en Guyane des spécificités entraînant une prise en charge et un raisonnement médical parfois différents. Parallèlement à ces pathologies, de nombreuses maladies tropicales sont par ailleurs présentes sur un mode endémique et / ou épidémique telles que le paludisme, la leishmaniose, la maladie de Chagas, l'histoplasmose ou la dengue. De plus, la dermatologie amazonienne est extrêmement variée, allant de pathologies rares, mais graves (ulcère de Buruli, lèpre), à d'autres fréquentes et bénignes telles que les poux d'agouti (acariens de la famille des Trombiculidae) ou la papillonite. Les envenimations par la faune sauvage ne sont pas rares, et méritent une prise en charge appropriée au taxon incriminé. Les pathologies obstétricale, cardiovasculaire et métabolique cosmopolites prennent parfois en Guyane une dimension particulière à prendre en compte dans la prise en charge des patients. Enfin, différents types d'intoxication sont à connaître par les praticiens, notamment aux métaux lourds. Les ressources de niveau européen offrent des possibilités diagnostiques et thérapeutiques inexistantes dans les pays et régions des environs, permettant ainsi la prise en charge de maladies peu connues ailleurs. Du fait de ces mêmes ressources de niveau européen, la recherche en Guyane occupe une place clé au sein de la région amazonienne, malgré une population moins nombreuse que dans les pays alentour. Ainsi, certaines pathologies telles que l'histoplasmose du patient immunodéprimé, la toxoplasmose amazonienne ou la fièvre Q ne sont pratiquement pas décrites dans les pays voisins, probablement du fait d'un sous-diagnostic lié à des ressources plus limitées. La Guyane joue ainsi un rôle moteur dans l’étude de ces pathologies. L'objectif de ce panorama est d'orienter les soignants venant ou exerçant en Guyane dans leur pratique quotidienne, mais également les praticiens prenant en charge des personnes au retour de Guyane.

show abstract

Dynamics of SARS-CoV-2 lineages in French Guiana in 2020–2021: 4 epidemic waves with cross-influences from Europe and South America

Cited by 3 publications

References 25 publications

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Panorama des pathologies infectieuses et non infectieuses de Guyane en 2022

Contact Info

Product

Resources

About