Dynamics of redox related elements (Fe, Co, Zn, and Se) and oxidative stress caused by Se-deficiency in rats

Sakuma, Yasunobu; Matsuoka, K.; Honda, Chikako; Matsumoto, Shingo; Endo, Kazutoyo

doi:10.1007/s10967-008-1011-1

Cited by 1 publication

(1 citation statement)

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“…Four glutathione peroxidases (GPX) as well as thioredoxin reductase and other selenoproteins act as oxidant scavengers in various tissues. Sakuma et al (2008), for example, demonstrated that rats denied Se exhibited low liver Se concentrations, low GPX activity, and higher bile hydrogen peroxide and oxidative stress levels. Similarly, 65 domestic cattle with initially 0.058 mg/kg wet weight (ww) liver Se and GPX activity of 35 IU/g hemoglobin, when treated with Se boluses, exhibited an increase in liver Se to 0.070 mg/kg (ww) and GPX activity of 263 IU/g (Hidiroglou et al 1987).…”

Section: Biochemical Rolesmentioning

confidence: 99%

The implications of selenium deficiency for wild herbivore conservation: a review

Flueck

Smith-Flueck²,

Mionczynski³

et al. 2012

Eur J Wildl Res

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Selenium (Se) is required at a fundamental physiological level in all animals. Adequate levels of Se are necessary for proper bone metabolism, iodine metabolism, immune function, reproductive success, and recruitment. Selenium is a component of enzymes which scavenge oxidative free radicals that would otherwise degrade cell membranes. Severe deficiency results in obvious symptoms such as white muscle disease in ungulates. However, more frequently, deficiency may be chronic and subclinical. Individuals then display no obvious signs of malady, yet performance suffers until their populations decline without apparent cause or through proximate factors which obscure underlying primary factors. Although well known in domestic stock, the link between population performance and Se deficiency in wild populations has been difficult to firmly establish. Confounding factors include the role of vitamin E, which also acts as an antioxidant to mitigate the need for Se under some circumstances; changing Se requirements at changing times in animal life history; changing Se requirements in relation to pollution levels and other factors causing oxidative stress; and the non-uniform distribution of Se in its various chemical forms in the environment. The latter point is especially important to wild populations that have been reduced to remnant portions of their previous range. Here, we have reviewed the literature of Se in wildlife as well as provided an introduction to Se in physiology and Se behavior in the environment for the wildlife researcher and manager. We conclude that unrecognized Se deficiency may often impede optimal population performance, and we provide recommendations for habitat analysis with regard to Se which can be used in future research. Finally, evidence that the amount of available Se in the environment is decreasing from anthropogenic causes is shown.

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Section: Biochemical Rolesmentioning

confidence: 99%