Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging

Morgiève, Margot; N’Diaye, K.; Haynes, William; Granger, Bernard; Clair, Anne-Hélène; Pélissolo, Antoine; Mallet, Luc

doi:10.1017/s0033291713002237

Cited by 67 publications

(65 citation statements)

References 57 publications

(103 reference statements)

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“…Unfortunately, few of the reviewed studies have reported neural changes specific to a symptom dimension, but one finding of post-treatment changes in insula activity during exposure to disgust-generating pictures (Schiepek et al, 2013) provides some evidence for how therapy may affect emotional processing of specific stimuli. Also, while two studies only included patients with either washing (Baioui et al, 2013) or checking symptoms (Morgiève et al, 2013), their findings do not substantially differ from other studies involving participants with mixed symptoms.…”

Section: Discussionmentioning

confidence: 54%

“…The small number of participants is a limitation of this study. Morgiève et al (2013) used fMRI during generic and individualized visual symptom provocation for 31 OCD participants with mainly checking symptoms. They also carried out neuroimaging mid-therapy and 6 months after CBT treatment, as well as standard pre-and post-treatment imaging.…”

Section: Task-related Functional Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review

Thorsen

Heuvel

Hansen

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Discussionmentioning

confidence: 54%

Section: Task-related Functional Imagingmentioning

confidence: 99%

Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review

Thorsen

Heuvel

Hansen

et al. 2015

Psychiatry Research: Neuroimaging

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“…The persistence of enhanced performance monitoring after symptom reduction is remarkable given some findings suggesting that hyperactivity of fronto-striatal brain circuits in OCD patients during resting state and after symptom provocation normalizes, at least in part, with symptom reduction during psychological or pharmacological treatment (2,32). Brain structures showing such functional normalization include the nucleus caudatus (33), the thalamus (28), and the anterior cingulate cortex (e.g., references 34,35). Although state-dependent variations in anterior cingulate functions have been shown, overactive performance monitoring, which has been linked to activity in this region, appears to be independent of current symptom state (17,18).…”

Section: Discussionmentioning

confidence: 99%

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

Riesel¹,

Endraß²,

Auerbach³

et al. 2015

AJP

106

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Objective: Overactive performance monitoring, as measured by the error-related negativity in the event-related brain potential, represents one of the most robust psychophysiological alterations in obsessive-compulsive disorder (OCD). It has been proposed as an endophenotype for OCD because it is heritable and more prevalent in families of OCD patients. Consistent with this notion, it is also independent of symptom profile and symptom severity in cross-sectional studies. Longitudinally, it has been shown to be state independent in pediatric patients with OCD. The purpose of the present study was to investigate the state dependency of error monitoring by examining adult OCD patients before and after symptom reduction through cognitive-behavioral therapy (CBT).Method: Error-related and correct-related negativity as electrophysiological indicators of performance monitoring were recorded from 45 OCD patients and 39 healthy comparison subjects while performing a flanker task. Patients were assessed before starting and after completing a standard 30-session CBT, including exposure and response prevention, and healthy comparison subjects were tested after a comparable time interval.Results: Pretreatment, patients with OCD were characterized by enhanced error-related and correct-related negativity compared with healthy comparison subjects. This difference persisted after treatment when symptoms were substantially reduced. There was no significant correlation between symptom improvement and changes in performance monitoring and no difference in performance monitoring between treatment responders and nonresponders.Conclusions: This is the first longitudinal study in adult OCD patients showing stability of enhanced error monitoring following successful symptom reduction through CBT. It supports the hypothesis that overactive performance monitoring is an endophenotype that indicates vulnerability for OCD.

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“…[55,56] Although some studies have not replicated the inverse relationship with treatment outcome in these regions, [60][61][62] no studies have reported greater activation in OFC or ACC associated with medication treatment outcome in OCD. [64,65] This finding suggests that pretreatment OFC activation may differentiate potential responders to medication versus CBT. [64,65] This finding suggests that pretreatment OFC activation may differentiate potential responders to medication versus CBT.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 93%

“…Although some have reported greater pretreatment caudate activation at rest [7] or in response to symptom provocation [55] associated with better outcomes, others have found that less resting caudate metabolism is associated with better medication response. [57,63,64] In summary, there is evidence to suggest that pretreatment activation in OFC and ACC may predict medication outcomes, and possibly even differentiate medication and CBT responders. The caudate has not been identified as a predictor of CBT outcome.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Toward the Application of Functional Neuroimaging to Individualized Treatment for Anxiety and Depression

2014

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Functional neuroimaging has led to significant gains in understanding the biological bases of anxiety and depressive disorders. However, the ability of functional neuroimaging to directly impact clinical practice is unclear. One important method by which neuroimaging could impact clinical care is to generate single patient level predictions that can guide clinical decision-making. The present review summarizes published functional neuroimaging studies of predictors of medication or psychotherapy outcome in major depressive disorder, obsessive-compulsive disorder (OCD), posttraumatic stress disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. In major depressive disorder and OCD, there is converging evidence of specific brain circuitry that has both been implicated in the disordered state itself, and where pretreatment activation levels have been predictive of treatment response. Specifically, in major depressive disorder, greater pretreatment ventral and pregenual anterior cingulate cortex (ACC) activation may predict better antidepressant medication outcome but poorer psychotherapy outcome. In OCD, activation in the ACC and orbitofrontal cortex has been inversely associated with pharmacological treatment response. In other anxiety disorders, research in this area is just beginning, with the ACC potentially implicated. However, the question of whether these results can directly translate to clinical practice remains open. In order to achieve the goal of single patient level prediction and individualized treatment, future research should strive to establish replicable models with good predictive performance and clear incremental validity.

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Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging

Cited by 67 publications

References 57 publications

Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review

Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

Toward the Application of Functional Neuroimaging to Individualized Treatment for Anxiety and Depression

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