Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction

Nonoshita, Akiko; Nishi, Yoshihiro; Takushima, Sachiyo; Oshima, Minako; Hosoda, Hiroshi; Kangawa, Kenji; Kojima, Masayasu; Mifune, Hiroharu; Tanaka, Eiichiro; Hori, D.; Kamura, Toshiharu

doi:10.1016/j.placenta.2010.02.013

Cited by 14 publications

(8 citation statements)

References 44 publications

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“…However, there have been no reports concerning the interactions of the NOS‐NO‐sGC‐cGMP and NP‐NPR‐cGMP systems in the placenta of hypertensive diseases of pregnancy. We have reported previously on the dynamics of placental ghrelin production using pregnant Dahl‐S rats fed a high‐salt diet as an animal model of intrauterine growth restriction . The present study investigated whether Dahl‐S rats fed a high‐salt diet during pregnancy could be useful as an animal model for superimposed pre‐eclampsia.…”

Section: Introductionmentioning

confidence: 93%

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Changes in the nitric oxide‐soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt‐sensitive rats

Takushima

Nishi

Nonoshita

et al. 2014

J of Obstet and Gynaecol

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As Dahl-S rats with excess salt-loading during pregnancy exhibited pathological changes similar to those observed in female humans with pre-eclampsia/superimposed pre-eclampsia, this rat could be useful as an animal model of superimposed pre-eclampsia. In the placentas of hypertensive Dahl-S rats, vasodilatation seemed to be disturbed by the deregulation of both the NO-sGC-cGMP and NP-NPR-cGMP systems.

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Section: Introductionmentioning

confidence: 93%

“…Like persons of African‐American ethnicity, Dahl‐S rats exhibit an upregulation of the Na‐K‐2Cl co‐transporter at the thick ascending limb of Henle's loop. In this respect, pregnant Dahl‐S rats may be very useful as an animal model of hypertensive diseases of pregnancy, especially of superimposed pre‐eclampsia …”

Section: Introductionmentioning

confidence: 99%

Changes in the nitric oxide‐soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt‐sensitive rats

Takushima

Nishi

Nonoshita

et al. 2014

J of Obstet and Gynaecol

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“…16 PCR was performed with a commercially available PCR kit (Go-Taq Master MixTM: Promega, Madison, WI, USA) with each primer set to amplify the transcripts for ghrelin (Accession No. NM_021669, 32 cycles).…”

Section: Reverse Transcription-polymerase Chain Reaction (Pcr) For Mrmentioning

confidence: 99%

“…Conversely, there are few reports describing the influence of BP, including antihypertensive treatment, on the plasma levels of ghrelin in animal models of hypertension. 14- 16 The present study investigated the effects of continuous antihypertensive treatment on the plasma levels of active ghrelin using a spontaneously hypertensive rat model (SHR/Izm) 17, 18 and their normotensive control, Wistar-Kyoto rats (WKY) to elucidate whether physiologically secreted ghrelin was able to regulate systemic BP. The abnormal regulation of ghrelin production in SHR is discussed as a possible mechanism of hypertension in this animal model.…”

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confidence: 99%

Disrupted Regulation of Ghrelin Production Under Antihypertensive Treatment in Spontaneously Hypertensive Rats

Hamada

Nishi

Tajiri

et al. 2012

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp hrelin is an acylated peptide hormone mainly produced in the stomach. 1 The third amino acid residue, serine (ser3), of mammalian ghrelin peptides is modified by the addition of an acyl group from fatty acids. 2 This acyl-modification is essential for the biological activity of ghrelin, which is exerted through the activation of the growth hormone (GH) secretagog-receptor (ghrelin receptor). Ghrelin functions primarily as an orexigen 3 and a GH-releasing hormone. 1 Various other physiological roles have been reported, including modulation of energy metabolism, 4 and regulation of the autonomic nervous system 5,6 and cardiovascular system. 7On the other hand, ghrelin is known to possess an antihypertensive effect. 8 It decreases the mean arterial pressure by directly affecting endothelial cells 9 and vascular smooth muscle cells, 10 or by working centrally to decrease the sympathetic outflow. 11 In fact, the continuous antagonism of the ghrelin receptor induced the early onset of hypertension in an animal model of salt-sensitive hypertension, 12 and the low levels of plasma ghrelin seen in association with obesity and insulin resistance impose an additive factor in the cascade of molecular abnormalities driving the progression of hypertension or type 2 diabetes. Background: Ghrelin is an acylated peptide hormone mainly secreted from the stomach. When administrated externally it modulates vascular tone mainly through the regulation of autonomic nerve activity. However, the effects of blood pressure (BP) on the production and secretion of ghrelin remain to be clarified.

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“…Low levels of ghrelin in the thirdtrimester myometrium are thought to prepare the uterus prior to labor (21). However, in term pregnancy, the placental ghrelin-ghrelin receptor system in the intrauterine growth restriction of rat models is speculated to continue to operate for the compensation of fetal development and fetoplacental circulation (22). It was proposed that chronic treatment of mothers with ghrelin during the last stage of pregnancy prompts fetal growth through stimulation of cell proliferation (23).…”

Section: Discussionmentioning

confidence: 99%

Association between maternal ghrelin levels and hyperemesis gravidarum

Kaygusuz¹,

Gümüş²,

Yıldırım³

et al. 2013

Turk J Med Sci

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New optically active poly(ester-imide)s (PEIs) containing bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic diimide in the main chain were prepared by the reaction of N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)bis-L-valine 4 as a diacid monomer with various aromatic diols 5a-g in a system of tosyl chloride (TsCl), pyridine (Py), and N,N-dimethylformamide (DMF). The reactions with TsCl were significantly promoted by controlling alcoholysis with diols, in the presence of catalytic amounts of DMF, to give a series of optically active poly(ester-imide)s. The resulting new polymers were obtained in good yields and inherent viscosities, ranging between 0.36 and 0.62 dL g −1 , and were characterized with FT-IR and 1 H-NMR spectroscopy, including specific rotation. All of these polymers were highly organosoluble at room temperature in solvents like N,N-dimethylacetamide (DMAc), N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), and sulfuric acid. The thermal stability of the resulting PEIs was evaluated with thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) techniques under a nitrogen atmosphere, which indicated that the residual weight percent of the polymers at 600 • C was 43.69%-60.5% and showed that they are moderately thermally stable.

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Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction

Cited by 14 publications

References 44 publications

Changes in the nitric oxide‐soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt‐sensitive rats

Changes in the nitric oxide‐soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt‐sensitive rats

Disrupted Regulation of Ghrelin Production Under Antihypertensive Treatment in Spontaneously Hypertensive Rats

Association between maternal ghrelin levels and hyperemesis gravidarum

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