Dynamics of oxidative stress and urinary excretion of melatonin and its metabolites during acute ischemic stroke

Ritzenthaler, Thomas; Lhommeau, Isabelle; Douillard, Samuel; Cho, Tae-Hee; Brun, Jocelyne; Patrice, Thierry; Nighoghossian, Norbert; Bruno, Claudio

doi:10.1016/j.neulet.2013.02.073

Cited by 24 publications

(21 citation statements)

References 26 publications

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“…Synaptic plasticity modification by CR and the possible antioxidant effect of a rhythmic melatonin have been proposed to explain the negative effects of circadian disruption in pathology. The severity of ischaemia in a mice model of cerebral infraction was related to circadian disruption, emphasizing a neuroprotective effect of normal CR during stroke in humans . Imbalanced inflammatory response was proposed as a possible mechanistic link between altered CR and health through molecular properties of melatonin (and subsequent cellular messengers) and its rhythmic secretion.…”

Section: Discussionmentioning

confidence: 99%

Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients

Gobert

Luauté

Raverot

et al. 2019

Journal of Pineal Research

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Circadian rhythmicity (CR) is involved in the regulation of all integrated functions, from sleep‐wake cycle regulation to metabolic function, mood and cognition. However, the interdependence of CR, cognition and consciousness has been poorly addressed. To clarify the state of CR in coma and to determine the chronological relationship between its recovery and consciousness after brain lesions, we conducted a longitudinal observational study investigating how the state of CR was chronologically related with the recovery of behavioural wakefulness, cognition and/or awareness. Among 16 acute comatose patients, we recruited two 37‐year‐old patients with a persistent disorder of consciousness, presenting diencephalic lesions caused by severe traumatic brain injuries. Two biological urinary markers of CR were explored every 2 hours during 24 hours (6‐sulfatoxymelatonin, free cortisol) with a dedicated methodology to extract the endogenous component of rhythmicity (environmental light recording, near‐constant‐routine protocol, control of beta‐blockers). They presented an initial absence of rhythmic secretions and a recovered CR 7‐8 months later. This recovery was not associated with the restoration of behavioural wakefulness, but with an improvement of cognition and awareness (up to the minimally conscious state). MRI showed a lesion pattern compatible with the interruption of either the main hypothalamic‐sympathetic pathway or the accessory habenular pathway. These results suggest that CR may be a prerequisite for coma recovery with a potential but still unproven favourable effect on brain function of the resorted circadian melatonin secretion and/or the functional recovery of the suprachiasmatic nucleus (SCN). Assessing circadian functions by urinary melatonin should be further explored as a biomarker of cognition reappearance and investigated to prognosticate functional recovery.

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Section: Discussionmentioning

confidence: 99%

Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients

Gobert

Luauté

Raverot

et al. 2019

Journal of Pineal Research

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“…Melatonin and its metabolites are involved in the modulation of oxidative stress (11) in human acute stroke by preventing the increase of iNOS and eNOS, and also by decreasing excitototoxic glutamate release (12); these two latter effects are mediated by the activation of MT2 melatonin receptors (13). In addition, due to its neuroprotective profile, melatonin is potentially useful for neurodegenerative diseases (14), although clinical trials are still not conclusive.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models

et al. 2015

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“…The difference in TAC measurement methods could be the reason for the inconsistent results between the current study and that of Genula at al. and Ritzenthler et al (22), which found that TAC decreased on the first day following IS and continued to decrease for nearly 5 days.…”

Section: Discussionmentioning

confidence: 91%

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

et al. 2016

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Background and Aim: Oxidative stress is a major mechanism involved in stroke pathogenesis. The present study evaluated and compared oxidative stress parameters in patients with ischemic and hemorrhagic stroke (IS and HS) at the time of hospitalization and 1 week after hospitalization. Methods: This was a case-control study with 87 stroke patients (58 IS and 29 HS) as the case and 58 normal individuals as the control group. Sampling was done at the time of hospitalization and after 1 week. The serum total antioxidant capacity (TAC), thiol group, and F2-isoprostan levels were measured using Ferric Reducing Antioxidant Power (FRAP), Elman, and Enzyme Linked Immunosorbent Assay ELISA methods, respectively. Results: At the time of hospitalization, there was no significant difference in TAC and F2-isoprostan levels between the case and

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Dynamics of oxidative stress and urinary excretion of melatonin and its metabolites during acute ischemic stroke

Cited by 24 publications

References 26 publications

Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients

Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

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