2010
DOI: 10.1007/s11538-009-9469-8
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Dynamics of Notch Activity in a Model of Interacting Signaling Pathways

Abstract: Networks of interacting signaling pathways are formulated with systems of reaction-diffusion (RD) equations. We show that weak interactions between signaling pathways have negligible effects on formation of spatial patterns of signaling molecules. In particular, a weak interaction between Retinoic Acid (RA) and Notch signaling pathways does not change dynamics of Notch activity in the spatial domain. Conversely, large interactions of signaling pathways can influence effects of each signaling pathway. When the … Show more

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Cited by 6 publications
(6 citation statements)
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References 52 publications
(69 reference statements)
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“…Namely the individuals never cross the boundaries, although they can live and freely move on the boundaries. This has been used in several studies (see for example [3,13,15]). Combining the zero-flux and Dirichlet boundary conditions gives rise to mixed boundary conditions, where the flux at each boundary is proportional to the population density.…”
Section: Model Developmentmentioning
confidence: 99%
“…Namely the individuals never cross the boundaries, although they can live and freely move on the boundaries. This has been used in several studies (see for example [3,13,15]). Combining the zero-flux and Dirichlet boundary conditions gives rise to mixed boundary conditions, where the flux at each boundary is proportional to the population density.…”
Section: Model Developmentmentioning
confidence: 99%
“…Ordinary and partial differential equations (ODEs and PDEs) have proven to be effective instruments in the study of real world problems in biology and medicine [7] [5] [9]. They will unquestionably continue to serve as interdisciplinary tools in future research in mathematical biology.…”
mentioning
confidence: 99%
“…Note that wavefronts and backs are qualitatively similar and general outcomes are satisfied for both of them. In addition to vast applications of traveling wavefronts in biology, various kinds of waves have been observed in chemical reactions ( [81], [179], [17] and references herein) as well as nonlinear optics [5], water waves [38], [39], [79], gas dynamics [160] and solid mechanics [171], [172], [173], [47]. Our primary concern in the present work is traveling and stationary wave solutions of the forms mentioned above.…”
Section: Waveforms In Biology and Ecologymentioning
confidence: 99%
“…Combining the zero-flux and Dirichlet boundary conditions, we get mixed boundary conditions where the flux at each boundary is proportional to the density at the boundary. and separating terms with h from terms with T we find two ordinary differential equations: (5 " 16) h rr + -h r + \h e e = A h, (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) /p…”
Section: A Nonlocal Rd Model In Symmetrical Domainmentioning
confidence: 99%
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