Dynamics of MASH1 Expression in Vitro and in Vivo Suggest a Non-Stem Cell Site of MASH1 Action in the Olfactory Receptor Neuron Lineage

Gordon, Melinda K.; Mumm, Jeff S.; Davis, Rohan A.; Holcomb, Joshua; Calof, Anne L.

doi:10.1006/mcne.1995.1028

Cited by 111 publications

(147 citation statements)

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“…Studies of neurogenesis and induced neuronal regeneration in adult animals indicate that the neuronal stem cell resides in the basal compartment of the OE (Camara and Harding, 1984;Gordon et al, 1995;Graziadei, 1973;Hinds et al, 1984;Mackay-Sim and Kittel, 1991;Moulton and Fig. 1.…”

Section: Progenitor Cells Of the Olfactory Receptor Neuron Lineage Nementioning

confidence: 99%

“…The earliest progenitor cell type that can be definitively identified in the ORN lineage is the MASH1-expressing progenitor, which is a proliferating cell type early in the lineage, but which does not appear to be a self-renewing stem cell (see below and Gordon et al, 1995). MASH1 is a basic-helix-loop-helix transcription factor that was cloned based on its homology to proneural genes of the achaete-scute complex in Drosophila (Johnson et al, 1990).…”

Section: Progenitor Cells Of the Olfactory Receptor Neuron Lineage Nementioning

confidence: 99%

“…HBCs lie adjacent to the basal lamina and express keratin intermediate filaments (Calof and Chikaraishi, 1989); these cells do not appear to be part of the neuronal lineage of the OE. The GBCs lie above horizontal basal cells, and it is this population of cells that has been shown to contain the progenitor cells that divide and give rise to ORNs in vivo (Caggiano et al, 1994;Gordon et al, 1995;Mackay-Sim and Kittel, 1991;Schwartz Levey et al, 1991). The OE rests on a basal lamina, beneath which lies a mesenchymal stroma.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, because studies in vitro and in vivo have shown that progenitor cells in the OE behave in a predictable and relatively uniform manner (e.g. Calof and Chikaraishi, 1989;Gordon et al, 1995;Schwartz Levey et al, 1991), it is possible to study the detailed biology of neurogenesis in the OE without the confounding issue of morphological and functional diversity in the neuronal population that arises from progenitor cell proliferation. Moreover, the increasing use of transgenic mouse technology in studying OE neurogenesis is making possible a detailed understanding of the regulation of neurogenesis at the molecular genetic level (e.g., Calof et al, 1996b;Cau et al, 2000;Murray et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Summarized briefly, the neuronal stem cell of the OE has been tentatively identified as the cell that gives rise to neuronal colonies in neuronal colony-forming assays (i.e., the neuronal colonyforming cell or neuronal CFU; see Mumm et al, 1996). The progeny of the neuronal stem cell is thought to be the MASH1-expressing neuronal progenitor, which undergoes 1-2 rounds of division to give rise to Immediate Neuronal Precursors (INPs; Gordon et al, 1995). INPs divide 1-2 times in vitro as well (cell cycle length Ϸ 17 hours), and then quantitatively give rise to postmitotic ORNs, which express the neural cell adhesion molecule within a few hours of their terminal S-phase (Calof and Chikaraishi, 1989;DeHamer et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Progenitor cells of the olfactory receptor neuron lineage

Calof

Bonnin

Crocker

et al. 2002

Microscopy Res & Technique

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The olfactory epithelium of the mouse has many properties that make it an ideal system for studying the molecular regulation of neurogenesis. We have used a combination of in vitro and in vivo approaches to identify three distinct stages of neuronal progenitors in the olfactory receptor neuron lineage. The neuronal stem cell, which is ultimately responsible for continual neuron renewal in this system, gives rise to a transit amplifying progenitor identified by its expression of a transcription factor, MASH1. The MASH1-expressing progenitor gives rise to a second transit amplifying progenitor, the Immediate Neuronal Precursor, which is distinct from the stem cell and MASH1-expressing progenitor, and gives rise quantitatively to olfactory receptor neurons. Regulation of progenitor cell proliferation and differentiation occurs at each of these three cell stages, and growth factors of the fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) families appear to play particularly important roles in these processes. Analyses of the actions of FGFs and BMPs reveal that negative signaling plays at least as important a role as positive signaling in the regulation of olfactory neurogenesis.

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Section: Progenitor Cells Of the Olfactory Receptor Neuron Lineage Nementioning

confidence: 99%

Section: Progenitor Cells Of the Olfactory Receptor Neuron Lineage Nementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Progenitor cells of the olfactory receptor neuron lineage

Calof

Bonnin

Crocker

et al. 2002

Microscopy Res & Technique

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130

111

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Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells

et al. 1998

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We have infused replication-incompetent retroviral vectors into the nasal cavity of adult rats 1 day after exposure to the olfactotoxic gas methyl bromide (MeBr) to assess the lineage relationships of cells in the regenerating olfactory epithelium. The vast majority of the retrovirus-labeled clones fall into three broad categories: clones that invariably contain globose basal cells (GBCs) and/or neurons, clones that always include cells in the ducts of Bowman's glands, and clones that are composed of sustentacular cells only. Many of the GBC-related clones contain sustentacular cells and horizontal basal cells as well. Most of the duct-related clones contain gland cells, and some also include sustentacular cells. Thus, the destruction of both neurons and non-neuronal cells that is caused by MeBr activates two distinct types of multipotent cells. The multipotent progenitor that gives rise to neurons and non-neuronal cells is a basal cell, whereas the progenitor that gives rise to duct, gland, and sustentacular cells resides within the ducts, based on the pattern of sparing after lesion and the analysis of early regeneration by using cell type-specific markers. We conclude that the balance between multipotency and selective neuropotency, which is characteristic of globose basal cells in the normal olfactory epithelium, is determined by which cell types have been depleted and need to be replenished rapidly.

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Cell dynamics in the embryonic and postnatal vomeronasal epithelium of snakes

Holtzman

1998

Microsc. Res. Tech.

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Dynamics of MASH1 Expression in Vitro and in Vivo Suggest a Non-Stem Cell Site of MASH1 Action in the Olfactory Receptor Neuron Lineage

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Cited by 111 publications

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Progenitor cells of the olfactory receptor neuron lineage

Progenitor cells of the olfactory receptor neuron lineage

Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells

Cell dynamics in the embryonic and postnatal vomeronasal epithelium of snakes

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