Dynamics of Malaria Drug Resistance Patterns in the Amazon Basin Region following Changes in Peruvian National Treatment Policy for Uncomplicated Malaria

Bacon, David; McCollum, Andrea M.; Griffing, Sean M.; Salas, Carola; Soberon, Valeria; Santolalla, Meddly L.; Haley, Ryan; Tsukayama, Pablo; Lucas, Carmen; Escalante, Ananías A.; Udhayakumar, Venkatachalam

doi:10.1128/aac.00249-10

Cited by 10 publications

(25 citation statements)

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“…In South America, reports on pfmdr1 copy numbers have been limited to Peru (Bacon et al . ), where only single‐copy isolates were detected and to Venezuela, revealing 12% of multicopy isolates (Griffing et al . ).…”

Section: Discussionmentioning

confidence: 99%

Increased pfmdr1 copy number in Plasmodium falciparum isolates from Suriname

Labadie-Bracho¹,

Adhin

2013

Tropical Med Int Health

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Section: Discussionmentioning

confidence: 99%

Increased pfmdr1 copy number in Plasmodium falciparum isolates from Suriname

Labadie-Bracho¹,

Adhin

2013

Tropical Med Int Health

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“…The double/triple/ quadruple/quintuple mutation haplotype frequency at the pfdhfr and pfdhps genes were calculated. For mixed-clone infection, the infection was classified as carrying resistant mutation for the codon as long as resistant alleles are present regardless of the presence of susceptible alleles (e.g., Ferreira et al, 2007; Zhong et al, 2007; Schonfeld et al, 2007; Bacon et al, 2009; Enosse et al, 2008). …”

Section: Methodsmentioning

confidence: 99%

Genetic structure of Plasmodium falciparum populations between lowland and highland sites and antimalarial drug resistance in Western Kenya

Bonizzoni

Afrane

Baliraine

et al. 2009

Infection, Genetics and Evolution

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Human travel to malaria endemic lowlands from epidemic highlands has been shown to increase the risk of malaria infections in the highlands. In order to gain insight on the impact of human travel, we examined prevalence, genetic variability and population genetic structure of Plasmodium falciparum in asymptomatic children from one highland site and three surrounding malaria endemic lowland sites in western Kenya, using multilocus microsatellite genotyping. We further analyzed the frequencies of mutations at the genes conferring resistance to chloroquine and sulphadoxinepyrimethamine. We found a significant decrease in malaria prevalence in the highland site from 2006 to 2007, one year after the introduction of the artemisinin-based combination therapy as first-line treatment for uncomplicated malaria and the scale-up of insecticide treated bed nets. Population genetic diversity, measured by the number of observed and effective microsatellite alleles and Nei's unbiased genetic diversity, was high and comparable for both highland and lowland populations. Analysis of molecular variance did not detect a significant genetic structure across highland and lowland regions. Similarly, mutations at key antimalarial -resistance codons of the pfcrt, pfmdr1, pfdhfr and pfdhps genes were found at comparable high frequencies in all four sites. High level of gene flow and lack of significant genetic structure in malaria parasites between highland and lowland areas suggest the importance of human travel in shaping parasite population structure.

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“…In South America, similar results have been seen in a variety of countries. In Venezuela and the Peruvian Amazon, chloroquine‐resistant parasites remained fixed in the population after chloroquine use was replaced by artemisinin‐based combination therapy (ACT) …”

Section: Resistance To Chloroquinementioning

confidence: 99%

Antimalarial drug resistance in Africa: key lessons for the future

Takala-Harrison

Laufer

2015

Annals of the New York Academy of Sciences

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Drug-resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs and have contributed significantly to the failure to control and eradicate malaria throughout the world. In this review, we describe the spread of resistance to chloroquine and sulfadoxinepyrimethamine, two old drugs that are no longer used owing to high rates of resistance, and examine the effect of the removal of drug pressure on the survival of resistant parasites. Artemisinin-resistant malaria is now emerging in Southeast Asia in a unique and unexpected pattern. We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drugresistant malaria in Africa in the future.

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Dynamics of Malaria Drug Resistance Patterns in the Amazon Basin Region following Changes in Peruvian National Treatment Policy for Uncomplicated Malaria

Cited by 10 publications

References 0 publications

Increased pfmdr1 copy number in Plasmodium falciparum isolates from Suriname

Increased pfmdr1 copy number in Plasmodium falciparum isolates from Suriname

Genetic structure of Plasmodium falciparum populations between lowland and highland sites and antimalarial drug resistance in Western Kenya

Antimalarial drug resistance in Africa: key lessons for the future

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