Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics

Shymon, Vasyl; Alfeldii, S.; Shymon, M.V.; Stoyka, V.

doi:10.25040/aml2019.04.045

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Одним з перспективних методів лікування уламкових переломів та дефектів кісток в сучасній травматології і ортопедії є використання синтетичних кальцій-фосфатних біоматеріалів [1], таких як біоскло. Ним заповнюють кісткові дефекти, що дозволяє у відділеному періоді статистично значимо підвищити міцність хворої кістки до показників, кращих за показники інтактних зразків [2].…”

Section: вступunclassified

“…Це біологічно активний матеріал, що складається зі склоподібної матриці й мікрокристалів. Біоактивне скло є біосумісним і належить до класу кераміки, що здатна взаємодіяти з тканинами організму [2].…”

Section: вступunclassified

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Bioglass and its application in modern treatment of osteooncological diseases

Turanska¹,

Kusyak²,

Petranovska³

et al. 2021

Poverhn.

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Bone tumor diseases are one of the main problems in modern clinical practice. After surgery, some of the tumor cells capable of proliferation may remain, leading to tumor recurrence. In addition, surgical ablation of bone tumors creates bone tissue defects. Therefore, the problem of manufacturing specific biomaterials with a dual function of treating bone tumors and regeneration of bone defects has become a priority. The use of methods of targeted delivery and local controlled release of drugs contributes to the creation of the desired therapeutic concentration of drugs in the disease focus and increases their bioavailability. In recent years, promising samples capable of effective controlled release have been developed in which cisplatin, doxorubicin and gemcitabine have been used as model chemotherapeutic drugs. These approaches have been promising and have shown the potential to destroy residual tumor cells, however, they may become resistant to such drugs, which leads to treatment failure. The main purpose of the review is to summarize the latest world experience in the synthesis, research and use of composites based on bioactive ceramic materials and modern antitumor drugs as promising implants, embodying a new generation of complex remedies for targeted delivery with osteoconductive and antitumor properties, prolonged action, for local application. Examples are given of bioglass application with cytotoxic / cytostatic components, as well as results of development of the newest directions of antitumor therapy of bones, in which acquisition of resistance of tumor cells is not observed. The antitumor functions of such multifunctional samples are performed, for example, by chemotherapy, photothermal therapy, magnetic hyperthermia, and photodynamic therapy. These data are of scientific, practical and methodical interest.

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Section: вступunclassified

Bioglass and its application in modern treatment of osteooncological diseases

Turanska¹,

Kusyak²,

Petranovska³

et al. 2021

Poverhn.

View full text Add to dashboard Cite

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Nutrition in modern socio-economic conditions of Ukraine as a health-forming factor (literature review)

Plakida,

Vastianov,

Horoshkov

et al. 2023

ECM

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A retrospective analysis of modern scientific literature was carried out. An analysis of modern features and trends in the state of the population's health and the influence of a complex of environmental factors on it, including nutrition, was carried out. The data on morbidity of the population of Ukraine according to the statistical collections for 2019–2022 were analyzed, and the health indicators of children of Ukraine were analyzed for the period (2019–2022). Nutrition is one of the environmental factors that directly affects the health of a person of any age. Rational and safe nutrition contributes to the normal growth and development of children, the prevention of diseases, the prolongation of people's lives, the increase in working capacity and provides conditions for their adaptation to the environment. Food is a multicomponent environmental factor containing more than 600 substances necessary for the normal functioning of the human body. Each of these substances occupies a certain place in the complex harmonious mechanism of biochemical processes and contributes to the proper physical development of a person. Unsatisfactory indicators of children's health are an urgent problem today. The steady decline in the number of practically healthy children, the ever-increasing flow of children suffering from chronic pathology and the disabled, is considered by many researchers today as a national tragedy. Analyzing the reasons for unsatisfactory indicators of the health of the population, it is possible to distinguish the influence of the following groups of factors: socio-economic (50%), environmental (20%), genetic (20%), state of medical care (10%). In the last decade, pediatricians, hygienists, and anthropologists have noted with great concern a particularly sharp deterioration in physical development and other criteria of health and motor fitness. Therefore, in our opinion, it is relevant to assess the health indicators of the child population as a prospect for the development of the future of the modern state. This study becomes especially relevant against the background of the incidence and prevalence of childhood diseases in recent years. Keywords: healthy lifestyle, hygienic assessment, diet, quality of life, morbidity, children.

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Dynamics of laboratory indicators of rats after implantation of bioglass material and glass ceramics

Cited by 2 publications

References 5 publications

Bioglass and its application in modern treatment of osteooncological diseases

Bioglass and its application in modern treatment of osteooncological diseases

Nutrition in modern socio-economic conditions of Ukraine as a health-forming factor (literature review)

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