Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination

Ploumi, Christina; Kyriakakis, Emmanouil; Tavernarakis, Nektarios

doi:10.1007/978-981-13-0989-2_5

Cited by 2 publications

(1 citation statement)

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“…Iron is essential for the survival of all organisms. Both iron deficiency and iron overload have detrimental effects on cellular and organismal physiology, highlighting the importance of tightly regulating intracellular iron abundance [41]. Owing to their OMM localization and their ability to bind and release Fe-S clusters, CISD1/mitoNEET and CISD2/NAF-1 proteins have been suggested to play an active role in preserving cellular iron homeostasis [42].…”

Section: Perturbation Of Iron Homeostasis Influences Lifespan and Hea...mentioning

confidence: 99%

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

2023

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Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger cytoprotective, or cell death pathways. Mitochondrial homeostasis and function decline with age. The mechanisms underlying the deterioration of mitochondrial homeostasis during ageing, or in age-associated pathologies, remain unclear. Here, we show that CISD-1, a mitochondrial iron-sulfur cluster binding protein, implicated in the pathogenesis of Wolfram neurodegenerative syndrome type 2, modulates longevity in the nematode Caenorhabditis elegans by engaging autophagy and the mitochondrial intrinsic apoptosis pathway. The anti-apoptotic protein CED-9 is the downstream effector that mediates CISD-1-dependent effects on proteostasis, neuronal integrity and lifespan. Moreover, intracellular iron abundance is critical for CISD-1 function, since mild iron supplementation is sufficient to decelerate ageing and partly ameliorate the disturbed mitochondrial bioenergetics and proteostasis of CISD-1 deficient animals. Our findings reveal that CISD-1 serves as a mechanistic link between autophagy and the apoptotic pathway in mitochondria to differentially modulate organismal proteostasis and ageing, and suggest novel approaches which could facilitate the treatment of Wolfram Syndrome or related diseases.

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Section: Perturbation Of Iron Homeostasis Influences Lifespan and Hea...mentioning

confidence: 99%

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

2023

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Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review

Rolić,

Yazdani,

Mandić

et al. 2024

Biol Trace Elem Res

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Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if above threshold. A similar balance applies to other elements: calcium (Ca), magnesium (Mg), and trace elements including copper (Cu), zinc (Zn), lead (Pb), cadmium (Cd), mercury (Hg), and nickel (Ni). These elements share some proteins involved in the absorption and transport of Fe. Cu and Cd can inhibit Fe absorption, while excess of Fe may antagonize Cu metabolism and reduce ceruloplasmin (Cp). Excessive Fe can hinder Zn absorption and transferrin (Trf) can bind to both Zn and Ni. Ca is able to inhibit the divalent metal transporter 1 (DMT1) in a dose-dependent manner to reduce Fe absorption and low Mg concentrations can exacerbate Fe deficiency. Pb competitively inhibits Fe distribution and elevated Cd absorption reduces Fe uptake. Exposure to Hg is associated with higher ferritin concentrations and Ni alters intracellular Fe metabolism. Fe removal by phlebotomy in hemochromatosis patients has shown to increase the levels of Cd and Pb and alter the concentrations of trace elements in some types of anemia. Yet, the effects of chronic exposure of most trace elements remain poorly understood.

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Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination

Cited by 2 publications

References 242 publications

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review

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