Dynamics of internally functionalized dendrimers

Grimm, J.P.; Dolgushev, Maxim

doi:10.1039/c6cp02406h

Cited by 22 publications

(38 citation statements)

References 42 publications

(89 reference statements)

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“…Otherwise, a more complex temperature behavior (superposition of the peaks 1 and 2) of 1/ T 1H should be observed for the Lys-2Lys dendrimer. This conclusion agrees well with results of the analytic theory 55 .…”

Section: Resultssupporting

confidence: 92%

NMR studies of excluded volume interactions in peptide dendrimers

Sheveleva

Markelov

Vovk

et al. 2018

Sci Rep

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Peptide dendrimers are good candidates for diverse biomedical applications due to their biocompatibility and low toxicity. The local orientational mobility of groups with different radial localization inside dendrimers is important characteristic for drug and gene delivery, synthesis of nanoparticles, and other specific purposes. In this paper we focus on the validation of two theoretical assumptions for dendrimers: (i) independence of NMR relaxations on excluded volume effects and (ii) similarity of mobilities of side and terminal segments of dendrimers. For this purpose we study 1H NMR spin-lattice relaxation time, T1H, of two similar peptide dendrimers of the second generation, with and without side fragments in their inner segments. Temperature dependences of 1/T1H in the temperature range from 283 to 343 K were measured for inner and terminal groups of the dendrimers dissolved in deuterated water. We have shown that the 1/T1H temperature dependences of inner groups for both dendrimers (with and without side fragments) practically coincide despite different densities of atoms inside these dendrimers. This result confirms the first theoretical assumption. The second assumption is confirmed by the 1/T1H temperature dependences of terminal groups which are similar for both dendrimers.

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Section: Resultssupporting

confidence: 92%

NMR studies of excluded volume interactions in peptide dendrimers

Sheveleva

Markelov

Vovk

et al. 2018

Sci Rep

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“…Recently, much of attention has been attracted to the local dynamics in dendrimers, both in theory (analytic theory [12,13,14] and computer simulations [15,16,17]) and experiments [18,19,20,21], see also recent review [22]. Especially the NMR relaxation experiments have remarkably advanced this field.…”

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confidence: 99%

Local NMR Relaxation of Dendrimers in the Presence of Hydrodynamic Interactions

2017

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We study the role of hydrodynamic interactions for the relaxation of segments' orientations in dendrimers. The dynamics is considered in the Zimm framework. It is shown that inclusion of correlations between segments' orientations plays a major role for the segments' mobility, that reveals itself in the NMR relaxation functions. The enhancement of the reorientation dynamics of segments due to the hydrodynamic interactions is more significant for the inner segments. This effect is clearly pronounced in the reduced spectral density ωJ(ω), whose maximum shifts to higher frequencies when the hydrodynamic interactions are taken into account.

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“…6a . According to the theory of orientation mobility in dendrimers 42 – 44 these results suggest that local orientational mobility in G6 is similar to the mobility of low generation dendrimers.…”

Section: Resultsmentioning

confidence: 70%

Investigation of Melts of Polybutylcarbosilane Dendrimers by 1H NMR Spectroscopy

Матвеев

Markelov

Dvinskikh

et al. 2017

Sci Rep

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Melts of polybutylcarbosilane (PBC) dendrimers from third (G3) up to sixth (G6) generations are investigated by 1H NMR spectroscopy in a wide temperature range up to 493 K. At room temperature, NMR spectra of G3-G5 dendrimers exhibit resolved, solution-like spectra (“liquid” phase). In contrast, the spectrum of the G6 dendrimer is characterized by a single unresolved broad line at whole temperature range, which supports the presence of an anomalous phase state of G6 at temperatures higher than glass transition temperature. For the first time, an unexpected transition of G5 dendrimer from a molecular liquid state to an anomalous state/phase upon temperature increase has been detected using NMR data. Specifically, an additional wide background line appears in the G5 spectrum above 473 K, and this line corresponds to a G5 state characterized by restricted molecular mobility, i.e., a state similar to the “anomalous” phase of G6 melt. The fraction of the G5 dendrimers in “anomalous” phase at 493 K is approximately 40%. Analysis of the spectral shapes suggests that changes in the G5 dendrimers are reversible with temperature.

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Dynamics of internally functionalized dendrimers

Cited by 22 publications

References 42 publications

NMR studies of excluded volume interactions in peptide dendrimers

NMR studies of excluded volume interactions in peptide dendrimers

Local NMR Relaxation of Dendrimers in the Presence of Hydrodynamic Interactions

Investigation of Melts of Polybutylcarbosilane Dendrimers by 1H NMR Spectroscopy

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