Dynamics of Insulin-Like Growth Factor-1 (Igf-1) in Children After Ab0-Incompatible Liver Transplantation

Шевченко, О. П.; Цирульникова, О. М.; Цирульникова, И. Е.; Курабекова, Р. М.; Olefirenko, G. A.; Степанова, О. И.; Готье, С. В.

doi:10.15825/1995-1191-2014-2-46-51

Cited by 5 publications

(2 citation statements)

References 9 publications

(7 reference statements)

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“…The result obtained shows that in children with ESLD, their body height and body mass are not associated with plasma GH levels, while IGF-1 levels correlate with these anthropometric characteristics. In the study group, no correlation between hormone levels and ESLD was found, which is inconsistent with an earlier study that showed a relationship between GH levels and PELD score [60,61]. This can be explained by many factors, in particular, differences in the structure of the incidence and degree of liver damage in patients in the studied samples.…”

Section: Correlation Of Peld Score With Body Height (A) and Body Mass...contrasting

confidence: 99%

Growth Hormone and Insulin-like Growth Factor-1 in Children with Cholestatic Diseases and Pediatric Liver Transplantation

Gautier¹,

Шевченко²,

Цирульникова³

et al. 2023

Growth Hormone - Impact and Insights in Human Beings

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The growth hormone/insulin-like growth factor 1 (GH/IGF-1) system is the most important regulator of growth, regeneration, and metabolism in children and adults. Children with congenital cholestatic diseases have elevated GH blood levels, which is combined with growth failure and body mass deficit. Congenital cholestatic diseases lead to end-stage liver disease (ESLD), where GH bioavailability, mediated through IGF-1, is impaired. Blood IGF-1 levels are decreased due to impaired production by the liver. This study included 148 children up to 5 years (60 months) old with congenital cholestatic diseases. The patients underwent liver transplantation (LT) at a leading transplant center in Russia. The clinical significance of the GH/IGF-1 axis in pediatric liver recipients was investigated. Relationship between the patients’ GH/IGF-1 levels and anthropometric parameters was analyzed before and after LT. It was shown that LT leads to renewal/recovery of GH-IGF-1 regulation and improved anthropometric parameters (body height and body mass) in pediatric recipients.

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Section: Correlation Of Peld Score With Body Height (A) and Body Mass...contrasting

confidence: 99%

Growth Hormone and Insulin-like Growth Factor-1 in Children with Cholestatic Diseases and Pediatric Liver Transplantation

Gautier¹,

Шевченко²,

Цирульникова³

et al. 2023

Growth Hormone - Impact and Insights in Human Beings

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“…Ранее нами было показано, что у детей с заболеваниями гепатобилиарной системы наблюдается повышенный уровень гормона роста, который сочетается с задержкой роста и массы тела и обусловлен снижением уровня ИФР-1 в крови. Трансплантация печени детям сопровождалась улучшением антропометрических показателей при восстановлении системы гормон роста -ИФР-1 [18,19]. Цель настоящей работы -анализ связи уровней гормона роста и ИФР-1 в крови с клиническими показателями, отражающими функцию печени, и выживаемостью при трансплантации печени детям.…”

Section: Association Between Growth Hormone and Insulin-like Growth Funclassified

Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients

Курабекова

Цирульникова

Pashkova

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Correlation between insulin-like growth factor 1 levels and tacrolimus dose in pediatric liver recipients

Курабекова

Цирульникова

Гичкун

et al. 2021

RJTAO

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Introduction. To prevent post-transplant complications associated with unbalanced immunosuppression, objective indicators reflecting the state of the immune system and associated with the immunosuppressant dose are required. In pediatric liver transplantation, an important indicator of hepatocellular function and restoration of anthropometric characteristics is insulin-like growth factor 1 (IGF-1), which exhibits both nonspecific and selective immunomodulator properties.Objective: to assess the correlation between growth hormone and IGF-1 levels and tacrolimus dose and blood concentrations in pediatric liver recipients and to determine the possibility of using the IGF-1 level in selecting the drug dose required to achieve its target concentration in the blood. Materials and methods. We examined 156 children aged from 2 to 105 (median – 8) months with liver cirrhosis of various etiology, who received liver from a living related donor. The concentration of growth hormone and IGF-1 was determined in blood plasma before, one month, and one year after transplantation using the enzyme-linked immunosorbent assay. Tacrolimus residual concentration was measured in the patient’s whole blood by immunochemical method.Results. Growth hormone levels in the blood of pediatric liver recipients did not correlate with the dose or concentration of immunosuppressant tacrolimus one month or one year after transplantation, whereas the IGF-1 content was directly related to tacrolimus dose one year later (r = 0.41, p = 0.001), but not a month after surgery. The correlation coefficient was higher in uncomplicated post-transplant recipients (r = 0.51, p = 0.002) than in those with complications (r = 0.26, p = 0.17). The diagnostic efficiency of the IGF-1 level as an objective criterion for selecting the tacrolimus dose required to achieve its target blood concentration was 0.80 ± 0.11; 95% CI [0.58–1.00] (p = 0.007). In recipients with blood IGF-1 levels ≥115.7 ng/mL, the probability of prescribing a tacrolimus dose ≥0.25 mg/kg/day was 14 times higher than in children with lower blood IGF-1 levels. The estimated accuracy of the test was 83%, positive predictive value was 71%, and negative predictive value was 85%.Conclusion. The IGF-1 level was found to correlate with tacrolimus dose in liver transplant recipients one year after transplantation. The diagnostic efficiency of IGF-1 as a potential indicator for choosing the tacrolimus dose required to achieve its target blood concentration is 80%, which suggests further study of the test to assess the effectiveness of immunosuppression and selection of an individual immunosuppressant dose.

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Dynamics of Insulin-Like Growth Factor-1 (Igf-1) in Children After Ab0-Incompatible Liver Transplantation

Cited by 5 publications

References 9 publications

Growth Hormone and Insulin-like Growth Factor-1 in Children with Cholestatic Diseases and Pediatric Liver Transplantation

Growth Hormone and Insulin-like Growth Factor-1 in Children with Cholestatic Diseases and Pediatric Liver Transplantation

Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients

Correlation between insulin-like growth factor 1 levels and tacrolimus dose in pediatric liver recipients

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