2009
DOI: 10.1095/biolreprod.109.077552
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Dynamics of INSL3 Peptide Expression in the Rodent Testis1

Abstract: The Leydig cell-specific factor insulin-like peptide 3 (INSL3) is involved in testicular descent during embryo development, and has been suggested to regulate spermatogenesis and bone metabolism in the adult. Using a new, sensitive assay specific for rodent INSL3, we have mapped the secretion of INSL3 into peripheral blood in mice and during postnatal male rat development (in female rats, circulating INSL3 is at the level of detection). Maximum INSL3 is measured at Postnatal Day (PD) 40 in the rat and decrease… Show more

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Cited by 84 publications
(81 citation statements)
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“…21 As Leydig cells differentiate during puberty, concomitant with the large and initially not well regulated pulses of LH from the pituitary, they initially give rise to an overproduction of INSL3 as a measure of Leydig cell differentiation status. Unlike testosterone, whose enzymatic production is acutely regulated by feedback from the pituitary, INSL3 is constitutively expressed.…”
Section: Discussionmentioning
confidence: 99%
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“…21 As Leydig cells differentiate during puberty, concomitant with the large and initially not well regulated pulses of LH from the pituitary, they initially give rise to an overproduction of INSL3 as a measure of Leydig cell differentiation status. Unlike testosterone, whose enzymatic production is acutely regulated by feedback from the pituitary, INSL3 is constitutively expressed.…”
Section: Discussionmentioning
confidence: 99%
“…20 INSL3 in blood was measured using a rodent-specific time-resolved fluorescent immunoassay, exactly as previously described. 21 Luteinising hormone (LH) was estimated using a commercial rat LH ELISA kit (USCN Life, Wuhan, China), according to the manufacturer's protocol. The range of detection for this assay was 0.78 mIU ml 21 -50 mIU ml 21 .…”
Section: Immunoassaysmentioning
confidence: 99%
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“…Recently several studies have described immunoassays capable of measuring circulating INSL3 levels [53,54]. In human males, the circulating levels of INSL3 are relatively high; about 1% of testosterone levels, but much greater than that of the sertoli cell hormone, inhibin-B [54].…”
Section: Functions Of Central Relaxin Family Peptide and Receptor Sysmentioning
confidence: 99%
“…In conscious rats, MS infusions of R3/I5 and the RXFP3 antagonist R3(BD23-27)R/I5 [100], differentially modulated hippocampal theta activity. In a behavioral paradigm that investigates theta rhythm-dependent spatial working memory, infusions of R3(BD23-27)R/I5 impaired rats performance of the task in a dose-dependent manner [53] (Fig. 7).…”
Section: Behavioral Activation and Arousalmentioning
confidence: 99%