Dynamics of impaired humour processing in schizophrenia – An EEG effective connectivity study

Adamczyk, Przemysław; Wyczesany, Mirosław; Daren, Artur

doi:10.1016/j.schres.2019.05.008

Cited by 9 publications

(23 citation statements)

References 72 publications

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“…Finally, effective connectivity maps were created to reveal the between-group differences in the information flow between specified ROIs of figurative language-related networks. Data were visualized using Trand3D 1.2 software (Department of Biomedical Physics, University of Warsaw; Blinowski et al 2014) in three pairs of directional contrasts, based on previously assessed contrasts from humor experiments (Adamczyk et al 2017(Adamczyk et al , 2019Chan et al 2012Chan et al , 2013: ABS vs NEU, MET vs ABS, MET vs NEU. Effective connectivity maps were created to reveal the between-group differences in the information flow.…”

Section: Discussionmentioning

confidence: 99%

“…answers) consisting of metaphorical sentences; they were then adapted to create three types of endings, i.e. NEU, ABS, MET following the punchline-based humor comprehension task procedure (Adamczyk et al 2017(Adamczyk et al , 2019. Next, 612 stories were divided into three separate sets (3 × 68 MET, 68 NEU, 68 ABS), thus ensuring that each person rated only one version of the same story/setup; they were then presented for pre-selective judgment to 60 healthy people (25 males, 35 females; mean age 27.65 ± 6.44 SD, min.…”

Section: Punchline-based Metaphor Comprehension Taskmentioning

confidence: 99%

“…In brief, functional Magnetic Resonance Imaging (fMRI) studies on humor (Adamczyk et al 2017 , 2018 ; Berger et al 2018 ) and irony (Rapp et al 2013 ; Varga et al 2013 ) have revealed aberrant activity within the left frontal and right temporo-parietal cortices in schizophrenia. Moreover, reversed lateralization of information flow assessed with electroencephalography (EEG) has been found during humor processing (Adamczyk et al 2019 ). Studies on metaphor processing in schizophrenia have revealed hyperactivation in the left inferior frontal gyrus (IFG) and suppressed activation in the right posterior temporal lobe (pTL) and the precuneus (Kircher et al 2007 , but see Mashal et al 2014 ), or suppressed activation in the right IFG together with compensatory hyperactivation in the left fronto-parietal regions (Mashal et al 2013 , 2014 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

et al. 2021

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Figurative language processing (e.g. metaphors) is commonly impaired in schizophrenia. In the present study, we investigated the neural activity and propagation of information within neural circuits related to the figurative speech, as a neural substrate of impaired conventional metaphor processing in schizophrenia. The study included 30 schizophrenia outpatients and 30 healthy controls, all of whom were assessed with a functional Magnetic Resonance Imaging (fMRI) and electroencephalography (EEG) punchline-based metaphor comprehension task including literal (neutral), figurative (metaphorical) and nonsense (absurd) endings. The blood oxygenation level-dependent signal was recorded with 3T MRI scanner and direction and strength of cortical information flow in the time course of task processing was estimated with a 64-channel EEG input for directed transfer function. The presented results revealed that the behavioral manifestation of impaired figurative language in schizophrenia is related to the hypofunction in the bilateral fronto-temporo-parietal brain regions (fMRI) and various differences in effective connectivity in the fronto-temporo-parietal circuit (EEG). Schizophrenia outpatients showed an abnormal pattern of connectivity during metaphor processing which was related to bilateral (but more pronounced at the left hemisphere) hypoactivation of the brain. Moreover, we found reversed lateralization patterns, i.e. a rightward-shifted pattern during metaphor processing in schizophrenia compared to the control group. In conclusion, the presented findings revealed that the impairment of the conventional metaphor processing in schizophrenia is related to the bilateral brain hypofunction, which supports the evidence on reversed lateralization of the language neural network and the existence of compensatory recruitment of alternative neural circuits in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Punchline-based Metaphor Comprehension Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

et al. 2021

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“…In this study, we used to construct the effective connectivity in four frequency band which delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-13 Hz) and beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) respectively between ADHD and HC. An average effective matrix for an ADHD subject and a HC subject of delta band was shown in Fig.…”

Section: Effective Connectivity Analysismentioning

confidence: 99%

“…The Functional connectivity represents the statistical correlation of the functional activities of different brain regions in time courses, and the statistical calculation is performed based on EEG signal [13][14][15]. Effective connectivity also called the directed functional connectivity which provided the causal information between each brain regions [16][17][18]. At present, most methods of calculating effective connectivity are based on parameter models, such as Granger causality model, dynamic causality model and multivariate regression (MVAR) model [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Graph theoretical analysis based on EEG effective connectivity in ADHD children

Shen

Wen

et al. 2021

Preprint

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This paper reports a new method to identify the ADHD children using EEG signals and effective connectivity techniques. In this study, the original EEG data is pre-filtered and divided into Delta, Theta, Alpha and Beta bands. And then, the effective connectivity graphs are constructed by applying independent component analysis, multivariate regression model and phase slope index. The measures of clustering coefficient, nodal efficiency and degree centrality in graph theory are used to extract features from these graphs. Statistical analysis based on the standard error of the mean are employed to evaluate the graph theory measures in each frequency band. The results show a decreased average clustering coefficient in delta band for ADHD subjects. Also, in delta band, the ADHD subjects have increased nodal efficiency and degree centrality in left forehead part and decreased in forehead middle.

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Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia

Huang,

Pu,

Guo

et al. 2024

Asian Journal of Psychiatry

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Dynamics of impaired humour processing in schizophrenia – An EEG effective connectivity study

Cited by 9 publications

References 72 publications

On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

On the Role of Bilateral Brain Hypofunction and Abnormal Lateralization of Cortical Information Flow as Neural Underpinnings of Conventional Metaphor Processing Impairment in Schizophrenia: An fMRI and EEG Study

Graph theoretical analysis based on EEG effective connectivity in ADHD children

Hypo- and hyper-activation in frontotemporal lobe during humor processing in patients with first episode schizophrenia

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