Dynamics of hepatic enzyme activity following birth asphyxia

Karlsson, Mathias; Blennow, Mats; Németh, Antal; Winbladh, Birger

doi:10.1080/08035250600693488

Cited by 47 publications

(67 citation statements)

References 23 publications

(27 reference statements)

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“…Our study for mean values of biochemical parameters with severity of birth asphyxia is similar to the findings observed by Mukesh Choudhry et al, [8] Karlsson M, WibergItzel E et al, [32] Tariqul I, Seikh AH et al in 2010 [33] and Chaitali et al in 2016. [34] Mortality was more in severe degree of asphyxia as compared to mild and moderate variety and it was statistically significant (p < 0.01).…”

Section: Discussionsupporting

confidence: 80%

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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BACKGROUND Perinatal asphyxia can lead to hypoxic ischaemic encephalopathy (HIE). The mortality due to hypoxic ischaemic encephalopathy is as high as 28.8% and morbidity is 30% of surviving newborn due to hypoxic ischaemic encephalopathy. Aims and Objectives-To study the plasma biochemical phenomena in neonates with hypoxic ischaemic encephalopathy in relation with severity of HIE. MATERIALS AND METHODSIt is a hospital-based prospective study done in tertiary care hospital in SCB Medical College Hospital and SVP PG Institute, Cuttack from November 2015 to October 2017. RESULTSThe babies with perinatal asphyxia develop hyponatraemia, hypocalcaemia, hyperkalaemia, high serum urea and creatinine, high serum ALT, AST, ALP, decrease in serum albumin and increase in Prothrombin time in proportion to the severity of asphyxia. CONCLUSIONA significant number of babies with birth asphyxia and deranged biochemical parameters either died or discharged with severe neurological sequelae. It can be concluded that deranged biochemical parameters are early indicators of poor outcome. Studies should be held on the effects of early correction of these metabolic derangements with their outcomes, so that it may invent a new horizon of treatment for birth asphyxia babies.

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Section: Discussionsupporting

confidence: 80%

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Das¹,

Murmu²,

Nayak³

2018

jemds

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“…The histological similarities between pigs and humans make it interesting to also investigate how plasma AST, ALT and LDH (markers of liver dysfunction known to increase during the first 72 h after asphyxia in term infants [9,11] ) respond to HI. Under normal conditions, healthy newborn pigs and human infants show a similar enzyme induction after birth with a substantial increase in plasma AST and LDH during the first 12-24 h after birth followed by a decrease back to the values seen directly after birth at the age of 72 h [30,31] .…”

Section: Discussionmentioning

confidence: 99%

“…In our newborn pig model of global HI, such a plasma enzyme increase has been completely lacking [22] or very modest with a plasma AST increase seen solely at 12 h after insult compared to values obtained before the insult [23] . The AST, ALT and LDH increase in plasma seen in adults [24,25] , term newborn infants [8][9][10][11] and adult pigs [21] as a response to HI is not seen in preterm newborn infants after asphyxia [11,26] . The reason for this is not fully understood but suggestions for this absence of enzyme elevation in preterm infants may be a higher resistance of the cellular membranes to HI or a low enzymatic pool in the liver cells [11,26] .…”

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confidence: 99%

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Liver Enzymes Cannot Be Used to Predict Liver Damage after Global Hypoxia-Ischemia in a Neonatal Pig Model

Karlsson¹,

Šatas

Stone

et al. 2009

Neonatology

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Background: The term newborn pig is an established model for studying both brain and organ pathology after hypoxia-ischemia (HI). Serial liver enzyme activity is often used to predict liver injury but little is known about the relation between consecutive values of different liver enzymes and histologically verified liver injury. Objective: To determine whether plasma values of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) differed between newborn pigs with liver injures and pigs with normal livers after a severe global HI insult. Methods: Nineteen ≤36-hour-old pigs underwent a 45-min global HI insult followed by 72-hour survival. Four histological sections from standardized areas within each liver were examined. Areas under the curve (AUC) for the enzymes were calculated and compared between pigs with pathological changes in the liver (n = 12) and pigs with normal liver histology (n = 7). Results: No differences in AUC for the enzyme values were seen between the groups. However, in pigs with liver injuries a transient significant increase in LDH at the end of the HI insult (928 U/l (567–1,031)) was seen compared to the baseline value (679 U/l (548–866), p = 0.010). Significantly more liver injury was seen in animals with the umbilical vein catheter (UVC) tip inserted into the liver (p = 0.040) compared to animals with the UVC tip located outside the liver. Conclusions: In newborn pigs subjected to global HI, only LDH increases alongside pathological changes in the liver. Normal values of ALT and AST do not exclude hepatic injury.

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“…Kriteria yang digunakan pada beberapa studi di atas memberikan hasil prevalens disfungsi hati yang ditemukan juga menjadi lebih besar. 7,14,15,17 Perbedaan tersebut tertera pada Tabel 5. Alasan lain mengenai perbedaan hasil disfungsi hati yang didapatkan pada berbagai studi sebelumnya mungkin dapat dijelaskan oleh perbedaan waktu pengambilan sampel darah.…”

Section: Insidens Disfungsi Hatiunclassified

Korelasi Nilai APGAR Menit Kelima Kurang dari Tujuh dengan Kadar Transaminase Serum pada Bayi Baru Lahir

Alhadar

Amir

Oswari

et al. 2016

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Latar belakang. Asfiksia dapat menyebabkan disfungsi multiorgan pada bayi baru lahir. Belum ada bakuemas mengenai definisi asfiksia. Hingga saat ini belum ada data di FKUI/RSCM mengenai insidens disfungsihati pada bayi yang mengalami asfiksia.Tujuan. Mengetahui insidens disfungsi hati pada bayi baru lahir dengan nilai Apgar menit kelima kurangdari 7 serta mengetahui korelasi antara nilai Apgar menit kelima kurang dari 7 dengan parameter uji fungsihati (AST/SGOT, ALT/SGPT, bilirubin total, bilirubin direk, bilirubin indirek serta waktu protrombin).Penelitian dilakukan di 5 rumah sakit di Jakarta dan Tangerang.Metode. Studi analitik potong lintang sejak Januari-Mei 2010. Subjek penelitian adalah bayi usia gestasi􀁴37 minggu dengan nilai Apgar menit kelima kurang dari 7. Dilakukan satu kali pemeriksaan uji fungsihati dalam rentang waktu usia bayi 24-96 jam. Bayi mengalami disfungsi hati bila didapatkan nilai ASTatau ALT lebih dari 100 U/L.Hasil. Disfungsi hati ditemukan pada 16 (34%) bayi dari 47 bayi dengan asfiksia. Tidak ada subjek yangmengalami kolestasis. Terdapat 5 (11%) subjek dengan pemanjangan PT >1,5 kali nilai kontrol. Tidak terbuktiterdapat korelasi antara nilai Apgar menit kelima kurang dari 7 dengan parameter uji fungsi hati.Kesimpulan. Bayi dengan nilai Apgar menit kelima kurang dari 7 mempunyai kecenderungan mengalamidisfungsi hati. Namun pada bayi dengan nilai Apgar menit kelima kurang dari 7, tidak terbukti adanyakorelasi.

show abstract

Dynamics of hepatic enzyme activity following birth asphyxia

Abstract: Birth asphyxia can induce an enzyme pattern in serum compatible to hypoxic hepatitis. There seems to be a correlation between aminotransferases in serum and the extent of CNS injury.

Cited by 47 publications

References 23 publications

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

A Study on Plasma Biochemical Phenomena in Hypoxic-Ischaemic Encephalopathy Cases in Tertiary Care Hospital

Liver Enzymes Cannot Be Used to Predict Liver Damage after Global Hypoxia-Ischemia in a Neonatal Pig Model

Korelasi Nilai APGAR Menit Kelima Kurang dari Tujuh dengan Kadar Transaminase Serum pada Bayi Baru Lahir

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