Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR

Bm, Brenner; Troy, JL; Daugharty, TM; Deen, WM; Robertson, C R

doi:10.1152/ajplegacy.1972.223.5.1184

Cited by 235 publications

(102 citation statements)

References 12 publications

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“…A consistent finding was the large reduction in rpf, secondary to increases in both AR and ER. As Brenner et al have observed, the sngfr is normally highly plasma flow-dependent in the Munich-Wistar rat (21). The major reduction in rpf should have been an adequate single explanation for the fall in sngfr.…”

Section: Morphologic Changes After Agbm Ab Infusionmentioning

confidence: 77%

“…Previous studies from this laboratory (11)(12)(13)(14)17) and the laboratory of Brenner and co-workers (21)(22)(23) Utilizing mathematical models of glomerular filtration as previously described (11,17) and applying data to the computer, a profile for EFP and the integrated value for EFP can be generated. A value for the glomerular permeability coefficient (LpA) is also generated by this method (sngfr = LpA -EFP).…”

Section: Introductionmentioning

confidence: 99%

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Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Blantz¹,

Wilson²

1976

J. Clin. Invest.

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A B S T R A C T Nephron filtration rate (sngfr) and the factors controlling filtration were examined before and within 60 min of the intravenous infusion of 225-450 Ag of antiglomerular basement membrane antibody (AGBM Ab) (> 50% antigenic saturation) in plasma-expanded (2.5% body wt) Munich-Wistar rats. Pressures in glonmerular capillaries (PG) and Bowman's space (Pt) were measured with a servo-nulling device, systemic (l7rA) and efferent arteriolar oncotic pressures (irE) were measured by microprotein methods, and nephron plasma flow (rpf) and sngfr were measured by micropuncture techniques in both control and post-AGBM Ab conditions in each rat. The sngfr fell from 52.7±2.9 to 24.1±+1.9 nl/min per g kidney wt (n = 7, P <0.001).Both afferent and efferent arteriolar resistances increased and rpf fell from 221±25 to 90±9 nl/min per g kidney wt (P < 0.001) but the hydrostatic pressure gradient across the glomerular membrane (AP = PG -Pt) increased from 37±1 to 50±2 mm Hg (P < 0.001). The increase in AP and a numerical decrease in TA both acted to maintain sngfr after AGBM Ab and effectively nullified the influence of decreased rpf upon sngfr. The nmean effective filtration pressure (EFP = AP -i) increased from 14±2 to 30±3 mm Hg (P < 0.001) while sngfr decreased. The major and critical reason for this reduction in sngfr was a decrease in the glomerular permeability coefficient from 0.077+0.017 to 0.014+0.001 nl/s per g kidney wt per mm Hg (P <0

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Section: Morphologic Changes After Agbm Ab Infusionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Blantz¹,

Wilson²

1976

J. Clin. Invest.

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“…In the mature rat the oncotic pressure in the glomerular capillaries of superficial nephrons has risen to equal the hydrostatic pressure before the end of the glomerular capillary (Brenner, Troy, Daugharty, Deen & Robertson, 1972;. As a consequence of the attainment of this filtration pressure equilibrium, a high degree of dependence of SNGFR an plasma flow in the adult rat can be predicted (Deen, Troy, Robertson & Brenner, 1973).…”

Section: Ratmentioning

confidence: 99%

Functional and morphologic maturation of superficial and juxtamedullary nephrons in the rat.

Rouffignac¹,

Monnens²

1976

The Journal of Physiology

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SUMMARY1. The development of single nephron glomerular filtration rate (SNGFR) was studied in both superficial and juxtamedullary nephrons in rats in relation to concomitant morphologic maturation. These experiments were carried out in rats between 23 and 91 days of age (between 36 and 275 g body weight) with the [14C]ferrocyanide infusion technique.2. SNGFR of the superficial and juxtamedullary nephrons increased with body weight, glomerular volume and proximal tubular length.3. The ratio SNGFR of the superficial (S) nephrons/SNGFR of the juxtamedullary (JM) nephrons rose from 0-60 in the 40-60 g rats to 0-84 in the adult rats, demonstrating the centrifugal functional maturation of the nephrons.4. The S/JM ratio for both glomerular volume and tubular length was constant and averaged 0-72 + 0-12 and 0-81 + 0 05, respectively, indicating that while the increase in SNGFR was greater for S than for JM nephrons, this was not accompanied by concomitant disproportionate increases of glomerular volume and/or proximal tubular length between these nephron categories during development in the rat.

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“…Much of our current understanding about glomerular dynamics stems from physiological studies of the Munich-Wistar rat, in which superficial glomeruli permit glomerular micropuncture and direct glomerular capillary pressure measurement. In hydropenic conditions, these rats have been shown (by multiple investigators) to be in a state of filtration pressure equilibrium (14,15). In these experiments, volume contraction and renal vasoconstriction resulting from the anesthetic and surgical procedures likely contributed to a diminution of RPF and a predisposition to filtration pressure equilibrium, although in volume-depleted animals, insight into the relation between RPF and filtration pressure equilibrium/disequilibrium is further confounded by a concurrent angiotensin II-mediated contraction of the K f (26).…”

Section: Discussionmentioning

confidence: 99%

“…The difference between ΔP and π GC at any given point along the glomerular capillary is the P UF . In many studies of the Munich-Wistar rat, ΔP and π GC were observed to equalize before the end of the glomerular capillary, bringing filtration to a halt, a phenomenon referred to as filtration pressure equilibrium (14,15). In humans, who are most likely in filtration pressure disequilibrium, the entire filtration surface area participates in filtration.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of living kidney donor glomerular dynamics after nephrectomy

2015

Kidney International

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ResultsResponse to donor nephrectomy in healthy humans. Twenty-one subjects underwent clinical, physiological, and radiological assessments immediately before, early after (median, 0.8 years), and late after (median, 6.1 years) (hereafter, pre-donation, early post-donation, and late post-donation) living kidney donation. A morphometric evaluation of glomeruli was performed on renocortical tissue that was obtained by wedge biopsy at the time of donor nephrectomy in 19 subjects. Baseline demographic, physio-BACKGROUND. Over 5,000 living kidney donor nephrectomies are performed annually in the US. While the physiological changes that occur early after nephrectomy are well documented, less is known about the long-term glomerular dynamics in living donors. METHODS.We enrolled 21 adult living kidney donors to undergo detailed long-term clinical, physiological, and radiological evaluation pre-, early post-(median, 0.8 years), and late post-(median, 6.3 years) donation. A morphometric analysis of glomeruli obtained during nephrectomy was performed in 19 subjects.RESULTS. Donors showed parallel increases in single-kidney renal plasma flow (RPF), renocortical volume, and glomerular filtration rate (GFR) early after the procedure, and these changes were sustained through to the late post-donation period. We used mathematical modeling to estimate the glomerular ultrafiltration coefficient (K f ), which also increased early and then remained constant through the late post-donation study. Assuming that the filtration surface area (and hence, K f ) increased in proportion to renocortical volume after donation, we calculated that the 40% elevation in the single-kidney GFR observed after donation could be attributed exclusively to an increase in the K f . The prevalence of hypertension in donors increased from 14% in the early post-donation period to 57% in the late post-donation period. No subjects exhibited elevated levels of albuminuria. CONCLUSIONS.Adaptive hyperfiltration after donor nephrectomy is attributable to hyperperfusion and hypertrophy of the remaining glomeruli. Our findings point away from the development of glomerular hypertension following kidney donation.

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Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR

Cited by 235 publications

References 12 publications

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Functional and morphologic maturation of superficial and juxtamedullary nephrons in the rat.

Longitudinal study of living kidney donor glomerular dynamics after nephrectomy

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