Dynamics of electrospinning of poly(caprolactone) via a multi‐nozzle spinneret connected to a twin screw extruder and properties of electrospun fibers

Senturk-Ozer, Semra; Ward, Daniel; Gevgilili, Halil; Kalyon, Dilhan M.

doi:10.1002/pen.23389

Cited by 18 publications

(19 citation statements)

References 53 publications

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“…Electrospinning has also been combined with traditional polymer processing techniques such as twin-screw extrusion in order to improve the ability to spin more viscous systems including polymer melts [60]. Moreover, such a process can generate high production rates when combined with multi-nozzle spinnerets ( Figure 7b) [61]. Recently also alternative spinning technologies for nanofibers have been introduced, such as a rotary jet-spinning technology that is capable of high rate spinning [62].…”

Section: Solution Jetmentioning

confidence: 99%

High Strength and High Modulus Electrospun Nanofibers

Yao

Bastiaansen

Peijs

2014

Fibers

230

171

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Electrospinning is a rapidly growing polymer processing technology as it provides a viable and simple method to create ultra-fine continuous fibers. This paper presents an in-depth review of the mechanical properties of electrospun fibers and particularly focuses on methodologies to generate high strength and high modulus nanofibers. As such, it aims to provide some guidance to future research activities in the area of high performance electrospun fibers.

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Section: Solution Jetmentioning

confidence: 99%

High Strength and High Modulus Electrospun Nanofibers

Yao

Bastiaansen

Peijs

2014

Fibers

230

171

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“…[47,48]. Concentration of actin on the cell periphery and at cell-cell junctions reveal that PCL and PCL/collagen nanofibrous scaffolds support cellular interactions among keratinocytes and direct them for the formation of strong cell sheets required for wound healing and epidermal tissue engineering [50,51].…”

Section: Discussionmentioning

confidence: 99%

Electrospinning of nanofibrous polycaprolactone (PCL) and collagen-blended polycaprolactone for wound dressing and tissue engineering

Zeybek¹,

Duman²,

Ürkmez³

2014

uujms

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Fabrication of nanofibrous biomaterials based on natural materials through various techniques is a popular research topic, particularly for biomedical applications. Electrospinning, a well-established technique for nanofiber production has also been extended for producing nanofibrous structures of natural materials that mimic natural extracellular matrix of mammalian tissues. Collagen nanofiber production utilizes hexafluoro propanol (HFP) as a solvent for electrospinning. A novel cost-effective electrospun nanofibrous membrane is established for wound dressing and allogeneic cultured epidermal substitute through the cultivation of human dermal keratinocytes for skin defects. Several synthetic polymers such as polycaprolactone (PCL) are generally electrospun for tissue engineering applications because of their remarkable mechanical stability and slow degradation rates. The large surface area of the polymer nanofibers with specific modifications facilitates cell adhesion and control of their cellular functions. The objectives of this study were to optimize fabrication parameters of electrospun nanofibrous membranes from biodegradable PCL and collagen-blended nanofibrous membranes to combine mechanical integrity and spinnability of PCL with high biocompatibility of collagen, and to examine keratinocyte attachment, morphology, proliferation, and cell-matrix interactions. Results prove that the porous nanofibrous PCL and modified PCL-blended collagen nanofibrous membranes are suitable for the attachment and proliferation of keratinocytes, and might have the potential to be applied as wound dressing as well as in tissue engineering as an epidermal substitute for the treatment of skin defects and burn wounds.

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“…However, some efforts are being focused on integrating the electrospinning method into continuous industrial processes. In the field of plastics engineering, the work of Senturk‐Ozer et al recently demonstrated the use of a twin‐screw extruder (TSE) as the front end of the electrospinning process. For this, high rates of electrospun jets were absolutely necessary and those could only be achieved by using multi‐nozzle spinnerets.…”

Section: Conclusion and Industrial Bioactive Applications For The Elmentioning

confidence: 99%

A review on electrospun polymer nanostructures as advanced bioactive platforms

2016

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This review article deals with latest literature studies on the potential use of polymer ultrathin and nanosized structures obtained by electrospinning to design novel engineered materials with bioactive properties. The electrofluidodynamic process offers the option to form high-performance bioactive systems based on polymer yarns of nanofibers or coatings of nanobeads with high surface-to-volume ratios. The electrospun and electrosprayed nanostructures can be further functionalized by encapsulation with bioactive fillers and substances. For both scenarios, the resultant polymer nanostructures present unique bioactive properties capable of providing a beneficial impact over human's health and with improved and advanced performance for biomedicine, pharmaceutics, nutrition, bioengineering, and healthcare applications. These novel functional materials attained by the electrospinning technology can be of interest for many bioactive applications such as functional food design, food packaging, functional coatings, controlled delivery of drug solutions and, mainly, tissue engineering. This article is purposely designed to gather, for the first time, most recent and promising multi-and inter-disciplinary develop-

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Dynamics of electrospinning of poly(caprolactone) via a multi‐nozzle spinneret connected to a twin screw extruder and properties of electrospun fibers

Cited by 18 publications

References 53 publications

High Strength and High Modulus Electrospun Nanofibers

High Strength and High Modulus Electrospun Nanofibers

Electrospinning of nanofibrous polycaprolactone (PCL) and collagen-blended polycaprolactone for wound dressing and tissue engineering

A review on electrospun polymer nanostructures as advanced bioactive platforms

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