Dynamics of directional coupling underlying spike-wave discharges

Sysoeva, Marina V.; Lüttjohann, Annika; Luijtelaar, E.L.J.M. van; Sysoev, Ilya V.

doi:10.1016/j.neuroscience.2015.11.044

Cited by 53 publications

(60 citation statements)

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“…We have successfully applied some of network analyses techniques to describe dynamics in coupling and based on a non-linear regression technique a cortical onset zone was described in the WAG/Rij rats, which was the bases for the cortical focus theory (Meeren et al, 2002;Meeren et al, 2005;Westmijse et al, 2009;van Luijtelaar et al, 2011). Next, different thalamic nuclei have a different function in the maintenance and abortion process of SWDs, as was established with different network analyses techniques (Lüttjohann and van Luijtelaar, 2015;Sysoeva et al, 2016). Drug related studies with network analyses methods of antiepileptic drugs are scares, in other domains they were already successfully applied (Ahnaou et al, 2014) and there are good reasons to assume that new mechanisms and new drug targets can be found with these new approaches acknowledging that epilepsy and certainly genetic generalized epilepsy, are network types of brain dysfunctions (Stefan and Lopes da Silva, 2013;Lüttjohann and van Luijtelaar, 2015).…”

Section: Some New Principles For Eeg Data Analysesmentioning

confidence: 99%

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Luijtelaar

Oijen

2020

Front. Pharmacol.

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The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generalized genetic epilepsy and in particular for childhood absence epilepsy. These animal models were described in the eighties of the previous century and both models have, among others, face, construct and predictive validity. Both models were and are currently used as models to predict the action of antiepileptic medication and other experimental treatments, to elucidate neurobiological mechanisms of spike-wave discharges and epileptogenesis. Although the electroencephalagram (EEG)/ electrocorticogram (ECoG) is imperative for establishing absence seizures and to quantify the for absence epilepsy typical spike-wave discharges, monitoring the animals behavior is equally necessary. Here an overview is given regarding the design of drug evaluation studies, which animals to use, classical and new EEG variables, the monitoring and quantification of the behavior of the rats, some pitfalls regarding the interpretation of the data, and some developments in EEG technology.

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Section: Some New Principles For Eeg Data Analysesmentioning

confidence: 99%

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Luijtelaar

Oijen

2020

Front. Pharmacol.

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“…Поскольку неоднократно отмечалось [5,14,16], что сигналы внутричерепных ЭЭГ во время абсансного приступа являются сильно нелинейными и применение к ним линейных мер может дать ошибочные или неполные результаты [9], в качестве простейшего из возможных подходов был использован нелинейный коэффициент корреляции, предложенный в работе [18].…”

Section: методыunclassified

“…В настоящее время существует значительное число как линейных, так и нелинейных, направленных и ненаправленных методов для выявления связанности по экспериментальным данным [8], в том числе методов, специально адаптированных к сигналам внутричерепных ЭЭГ [9] и для исследования динамики связанности в скользящем временном окне [10]. Однако значительное число существенных результатов в области исследования абсансной эпилепсии получены с помощью достаточно простых нелинейных мер, в частности, нелинейной корреляции [13] и функции взаимной информации [14]. При этом в работах [5,13,14] использовался весьма значительный набор данных: более 10 животных в каждом эксперименте и несколько сотен разрядов с сумме (как правило, не менее 10 разрядов от каждого животного), а итоговые данные, свидетельствующие, в частности, о значимом усилении связанности до начала приступа, являются результатом значительного усреднения.…”

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“…Однако значительное число существенных результатов в области исследования абсансной эпилепсии получены с помощью достаточно простых нелинейных мер, в частности, нелинейной корреляции [13] и функции взаимной информации [14]. При этом в работах [5,13,14] использовался весьма значительный набор данных: более 10 животных в каждом эксперименте и несколько сотен разрядов с сумме (как правило, не менее 10 разрядов от каждого животного), а итоговые данные, свидетельствующие, в частности, о значимом усилении связанности до начала приступа, являются результатом значительного усреднения. В действительности, остаётся не до конца ясным, присутствуют ли зафиксированные изменения всегда, либо только в ряде приступов, а также, насколько типичны временные характеристики этих изменений.…”

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Comparative Analysis of Methods for Estimation of Undirected Coupling from Time Series of Intracranial Eegs of Cortex of Rats-Genetic Models of Absence Epilepsy

Grishchenko¹,

Rijn²,

Sysoev³

2017

Math.Biol.Bioinf.

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Studying coupling between brain areas from its electromagnetic activity is one of the key approaches in epilepsy research now, since epileptic activity has been considered to be a result of pathological synchronization in the brain. Often, research is conducted on animal models, because this allows to perform intracranial measurement, and to get rid of interference caused by the skull and to receive signals from deeper regions of the brain such as thalamus or hippocampus. In this study, the intracranial recordings from the frontal and parietal areas of cortex are investigated with a nonlinear correlation coefficient and a mutual information function in a sliding time window. The coupling estimates obtained were subjected for statistical analysis for significance using surrogate data. The dynamics of connectivity between the frontal cortex and the parietal cortex was shown to vary from seizure to seizure and from animal to animal. Therefore, estimates of the significant change in connectivity associated with initiation of the absense seizure, found previously based on averaging over a large number of animals and a large number of seizures for an each animal, can be a result of contribution of a relatively small number of seizures (less than a half of considered), for which the changes are significant.

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“…(iii) The specific somatosensory-thalamo-cortical network should be considered to 480 further study the dynamical mechanism for SWD initiation, maintenance, and 481 termination in genetic rat models [18,65]. The exact interactions between cortex and 482 different thalamic nuclei are essential for understanding how the cortical 'focus' within 483 the perioral subregion of the somatosensory cortex drives other parts of the cortex and 484 the ventral basal complex of the thalamus.…”

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confidence: 99%

Unified Analysis of Global and Focal Aspects of Absence Epilepsy via Neural Field Theory of the Corticothalamic System

Yang

Robinson

2018

Preprint

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A physiology-based corticothalamic model is investigated with focal spatial heterogeneity, to unify global and focal aspects of absence epilepsy. Numerical and analytical calculations are employed to investigate the emergent spatiotemporal dynamics induced by focal activity as well as their underlying dynamical mechanisms. The spatiotemporal dynamics can be categorized into three scenarios: suppression, localization, and generalization of the focal activity, as summarized from a phase diagram vs. focal width and characteristic axon range. The corresponding temporal frequencies and spatial extents of wave activity during seizure generalization and localization agree well with experimental observations of global and focal aspects of absence epilepsy, respectively. The emergent seizure localization provide a biophysical explanation of the temporally higher frequency but spatially more localized cortical waves observed in genetic rat models that display characteristics of human absence epilepsy. Predictions are also presented for further experimental test. Author SummaryAbsence epilepsy is characterized by a sudden paroxysmal loss of consciousness accompanied by oscillatory activity propagating over many brain areas. Although primary generalized absence seizures are supported by the global corticothalamic system, converging experimental evidence supports a focal theory of absence epilepsy. Here we propose a dynamical mechanism to unify the global and focal aspects of absence epilepsy, with focal absence seizures associated with seizure localization, and the global ones associated with seizure generalization. Our corticothalamic model is used to investigate how seizure rhythms and spatial extents are related in these two different aspects of absence epilepsy. The results account for the difference of the experimentally observed seizure rhythms and spatial extents between humans and genetic rat models, which has previously been used to argue against the validity of such rats as animal models of absence epilepsy in humans.

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Dynamics of directional coupling underlying spike-wave discharges

Cited by 53 publications

References 34 publications

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

Comparative Analysis of Methods for Estimation of Undirected Coupling from Time Series of Intracranial Eegs of Cortex of Rats-Genetic Models of Absence Epilepsy

Unified Analysis of Global and Focal Aspects of Absence Epilepsy via Neural Field Theory of the Corticothalamic System

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