Dynamics of differentiated-renal epithelial cell monolayer after calcium oxalate injury: The role of cyclooxygenase-2

Casali, Cecilia I.; Pescio, Lucila Gisele; Sendyk, Dylan E.; Erjavec, Luciana C.; Gómez, Emanuel Morel; Parra, Leandro G.; Fernández-Tomé, María C.

doi:10.1016/j.lfs.2023.121544

Cited by 1 publication

(2 citation statements)

References 56 publications

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“…Figure 2 shows that nanoCOD crystals affected the progression of the cell cycle (Casali et al, 2023), affected the DNA synthesis progression of the cells, and ultimately inhibited cell proliferation. CDSPs prevented the progression of the cell cycle from the G0/G1 phase to the S and G2/M phases, that is, they inhibited renal tubular epithelial cells to adhere to CaOx crystals (Khamchun et al, 2021), thereby inhibiting the risk of kidney stone formation.…”

Section: Resultsmentioning

confidence: 99%

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Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis

Wang,

Liu,

Zhao

et al. 2024

Journal Cellular Physiology

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The inhibition of cell surface crystal adhesion and an appropriate increase in crystal endocytosis contribute to the inhibition of kidney stone formation. In this study, we investigated the effects of different degrees of carboxymethylation on these processes. An injury model was established by treating human renal proximal tubular epithelial (HK‐2) cells with 98.3 ± 8.1 nm calcium oxalate dihydrate (nanoCOD) crystals. The HK‐2 cells were protected with carboxy (‐COOH) Desmodium styracifolium polysaccharides at 1.17% (DSP0), 7.45% (CDSP1), 12.2% (CDSP2), and 17.7% (CDSP3). Changes in biochemical indexes and effects on nanoCOD adhesion and endocytosis were detected. The protection of HK‐2 cells from nanoCOD‐induced oxidative damage by carboxymethylated Desmodium styracifolium polysaccharides (CDSPs) is closely related to the protection of subcellular organelles, such as mitochondria. CDSPs can reduce crystal adhesion on the cell surface and maintain appropriate crystal endocytosis, thereby reducing the risk of kidney stone formation. CDSP2 with moderate ‐COOH content showed the strongest protective activity among the CDSPs.

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Section: Resultsmentioning

confidence: 99%

Section: Different Carboxylated Cdsps Inhibited the Decreased Viabili...mentioning

confidence: 99%

Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis

Wang,

Liu,

Zhao

et al. 2024

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

Dynamics of differentiated-renal epithelial cell monolayer after calcium oxalate injury: The role of cyclooxygenase-2

Cited by 1 publication

References 56 publications

Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis

Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis

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