Dynamics of Changes in Physiological Parameters of Mice with Different Radiosensitivity after Acute γ-Irradiation

Abstract

We studied radiosensitivity of 101/Hf, C3H/Sn, and C57Bl mice exposed to sublethal doses of γ-radiation. C57Bl mice responded to radiation much later than 101/Hf and C3H/Sn mice, while their adaptability was high enough. 101/Hf and C3H/Sn mice developed acute radiation sickness in a similar way. However, C3H/Sn mice showed better physiological indicators after radiation crisis. There was no noticeable improvement after the development of radiation sickness in 101/Hf mice. To assess individual radiosensitivity, integrated approach should be applied using the data obtained by different methods on several physiological levels.

New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose

“…The position of the peak corresponding to small particles in the IR group was shifted to the left (4.64 nm) in comparison with the control (6.25 nm), and the contribution of medium particles (50.3 nm) to the light scatter in this experimental group was significantly lower than in the AC group ( Figure 10 a). Thus, the subfraction distribution of serum particles in irradiated animals (IR group) did not return to normal by the end of the experiment, which is consistent with previously published data [ 42 ].…”

“…Irradiation induced significant shifts in the subfraction distribution of serum particles in mice ( Figure 9 ), which is consistent with previously published data [ 42 ]. In our DLS study, we showed for the first time that administration of hLf promoted recovery of serum homeostasis parameters to their normal values by the end of the experiment ( Figure 10 ).…”

“…Irradiation induced significant changes in the DLS spectra. A common pattern of changes in the subfraction composition of the serum after irradiation was an increase in the contribution of large particles (>122.92 nm) [ 42 ]. This reaction was observed in all experimental groups on day 3 after irradiation ( Figure 9 a,b).…”