Dynamics of Cd14+сd16+ Monocyte Subpopulations in Complication-Free Systemic Inflammatory Response Following Coronary Artery Bypass Graft Surgery

Матвеева, Г.; Головкин, Сергей Иванович; Кудрявцев, В. А.; Григорьев, В.; Чернова, Н. І.

doi:10.15789/1563-0625-2012-4-5-391-398

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…По современным представлениям моноциты и макрофаги человека разделяются фенотипически по уровню экспрессии высокоаффинных рецепторов CD14 и низкоаффинных рецепторов CD16 на разные в функциональном отношении субпопуляции [13,14]. Некоторые авторы сообщают о существовании двух субпопуляций моноцитов [15][16][17][18], среди которых преобладающей является субпопуляция так называемых «классических» моноцитов ("classical" monocytes). Моноциты этой субпопуляции экспрессируют на своей поверхности высокий уровень CD14-рецепторов и не экспрессируют CD16-рецепторы (CD14 ++ /CD16 -).…”

Section: рецепторы и функции моноцитовunclassified

“…У пациентов с инфекционными и воспалительными заболеваниями также выявлялось повышение пропорции моноцитов CD14 + /CD16 + по сравнению со здоровыми, при этом у них повышалась антигенпредставляющая функция моноцитов CD14 + /CD16 + и секреция ими провоспалительных цитокинов [9,14]. У пациентов с наследственной гиперхолестеринемией количество моноцитов с фенотипом СD16 + отрицательно коррелировало с уровнем липопротеинов высокой плотности и положительно -с уровнем атерогенных липидов [18,21]. В ряде исследований было отмечено, что моноциты больных с фенотипом СD16 + осуществляли повышенную экспрессию провоспалительных цитокинов TNF- [22], IL-6 [16], и IL-1 [22] по сравнению с здоровыми.…”

Section: рецепторы и функции моноцитовunclassified

“…Показано, что эти взаимодействия приводят к развитию основных этапов атерогенеза, нарушению гомеостаза, последствиями которого могут быть сердечно-сосудистые заболевания, такие как инфаркт миокарда, стенокардия, инсульт, онкологические и другие системные заболевания. Проанали-Psychiatry (Moscow) 18(3)'2020'76-85 MIA' ISSN2618-6667 (online)' journalpsychiatry.com DOI 10.30629/2618DOI 10.30629/ -6667-2020 зированы новые подходы в лечении иммунного воспаления и связанных с ним когнитивных нарушений, основанные на специфической блокаде хемокиновых рецепторов на поверхности активированных моноцитов.…”

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The Role of Monocytes Cellular and Molecular Mechanisms in the Development of Systemic Immune Inflammation. Part 1

Vasileva¹,

Брусов²

2020

Psychiatry

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Introduction: the important role of monocytes /macrophages, as well as cytokines produced by them was determined in the pathogenesis of mental disorders, as a macrophage-T-lymphocyte theory of bipolar disorder, schizophrenia and depression. According to this theory, there is an increase in the number of active circulating monocytes, macrophages and T-cells in patients with mental disorders. These cells migrate to the CNS as a result of the blood-brain barrier breach, destabilize the brain and lead to worsening of mental disorders.The aim of work: to review research data on the role of proinflammator monocytes in the development of immune inflammation in the pathogenesis of a number of systemic diseases and to examine the molecular mechanisms mediating the interaction of proinflammatory monocytes with other cells involved in immune inflammation.Material and methods: keywords “proinflammatory monocyte CD16+”, “cytokines”, “molecules of cell adhesion”, “monocyte-platelet aggregates”, “microglia”, “psychiatriс disorders”, are used to search for data published over the past 20 years in domestic and foreign studies in PubMed and e-Library.Conclusion: in the first part of the review, the research data concerning the studies of the functional characteristics of a monocytes subpopulation that express on their surface an increased level of CD16 receptors when activated were analyzed. Most of researchers associate the proinflammatory functions of monocytes with this subpopulation. Molecular mechanisms of monocytes activation, which include increased secretion of CD16 receptors, cytokines, chemokines and receptors for them involved in their interaction with vascular endothelial cells, with neurons in the CNS and also with platelets in the development of systemic inflammation, are considered. Analysis of these mechanisms allows us to better understand the immune aspects of inflammation in the brain mediated by the interaction of CD16+ monocytes with neuronal cells, which results in cognitive disorders in patients with mental disorders, as well as to identify related new approaches to the treatment of cognitive decline in these patients. Studies of the monocyte unit of immunity in patients with mental disorders will be covered in the second part of the review.

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Section: рецепторы и функции моноцитовunclassified

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The Role of Monocytes Cellular and Molecular Mechanisms in the Development of Systemic Immune Inflammation. Part 1

Vasileva¹,

Брусов²

2020

Psychiatry

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The role of hematological index in prognosis of outcomes in patients with acute coronary syndrome

Borisova¹,

Pushkin²,

Kim³

et al. 2018

Lab. sluzh.

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The major cause of acute coronary syndrome is atherosclerosis of coronary vessels. Inflammation and disorders of lipid metabolism are considered as the causes of development of atherosclerosis. Patients with acute coronary syndrome have a higher risk of recurrent cardiovascular events and mortality in short-and long-terms after the treatment. There is a number of risk scoring systems for the assessment of cardiovascular events. An approach of treatment is determined by the patient's risk of future cardiovascular events. Right treatment choice is shown to provide mortality decrease in patients with acute coronary syndromes. This review is devoted to the role of hematological indices (NLR, MCV, PDW, PLR) in the pathogenesis of atherosclerosis and the changes of their concentration in blood and can be used as prognostic tools and for risk stratification of ACS patients.

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Subpopulations of blood monocytes in patients with generalized hypoxia

et al. 2019

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The aim of the work is to establish general regularities and features of differentiation of blood monocytes into 4 subpopulations in diseases associated with circulatory and respiratory hypoxia.Materials and methods. 18 patients with ischemic heart disease (IHD), 12 patients with ischemic cardiomyopathy (ICMP), 14 patients with chronic obstructive pulmonary disease (COPD), 15 patients with newly diagnosed infiltrative pulmonary tuberculosis (PTB) and 12 healthy donors were examined. In whole blood, we determined the relative number of different subpopulations of monocytes by flow cytometry. The results were analyzed by statistical methods.Results. It is shown that an increase in the number of classical (80.56 [77.60; 83.55]%) and the deficit of intermediate (10.38 [9.36; 11.26]%), non-classical (6.03 [5.24; 6.77]%) and transitional (2.14 [1.41; 3.92] %) monocytes in the blood is determined in patients with COPD when compared with the group of healthy donors (p < 0.05). In groups of patients with PTB and IHD, an increase in the number of intermediate monocytes (26.24 respectively [22.38; 42.88] % and 25.27 [15.78; 31.39]%) and the lack of transitional cells (1.77 [1.36; 3.74]% and 2.68 [2.63; 4.0]%) at the normal content of classical and non-classical forms of monocytes (p < 0.05) is detected. In patients with ICMP, a decrease in the number of non-classical monocytes (up to 5.05 [4.08; 6.58]%) is combined with the normal cell content of other subpopulations (p < 0.05). The interrelation between the number of classical and intermediate monocytes in patients with COPD (r = –0.63; p < 0.05), PTB (r = –0.72; p < 0.01), IHD (r = –0.59; p < 0.05), ICMP (r = –0.58; p < 0.05) was established.Conclusion. In COPD associated with generalized hypoxia, an increase in the number of classical monocytes is combined with a deficiency of their other subpopulations in the blood. In PTB and IHD, antigenic stimulation of the immune system mediates accelerated differentiation of monocytes from classical to intermediate forms with a decrease in the number of transitional cells regardless of the etiology of the disease (infectious or non-infectious) and the type of hypoxia (respiratory or circulatory).

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Dynamics of Cd14+сd16+ Monocyte Subpopulations in Complication-Free Systemic Inflammatory Response Following Coronary Artery Bypass Graft Surgery

Cited by 4 publications

References 7 publications

The Role of Monocytes Cellular and Molecular Mechanisms in the Development of Systemic Immune Inflammation. Part 1

The Role of Monocytes Cellular and Molecular Mechanisms in the Development of Systemic Immune Inflammation. Part 1

The role of hematological index in prognosis of outcomes in patients with acute coronary syndrome

Subpopulations of blood monocytes in patients with generalized hypoxia

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