Dynamics of Axonal Growth and the Formation of Orderly Nerve Connections in the Fish Retinotectal System

Stuermer, Claudia A. O.

doi:10.1515/jbcpp.1990.1.1-4.165

Cited by 1 publication

(3 citation statements)

References 25 publications

(28 reference statements)

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“…In particular, it has been shown in several fish species, including zebrafish, that neuronal differentiation in the developing tectum is dependent upon innervation by the optic nerve (Schmatolla, 1972). The development of retinotectal projections and some of the molecular signals that affect the guidance of retinal axons to their central points of termination have been described in zebrafish (Stuermer, 1988, 1990; Burrill and Easter, 1994; Karlstrom et al, 1996). The first retinal axons leave the eye 34 hour post‐fertilization (hpf) and innervate the tectum by 70–72 hpf (Stuermer, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…Further, Stuermer (1990) presented evidence for spatial marker molecules that accurately lead the ganglion cell axons to target sites in the tectum. Karlstrom et al (1996) re‐examined retinotectal axon pathfinding in 5‐day‐old zebrafish, but from the aspect of mutations that affected the process.…”

Section: Introductionmentioning

confidence: 99%

“…Karlstrom et al (1996) speculated that a genetic approach may enable the identification of specific genes responsible for specific axonal pathfinding events. Presumably, those genes would determine the production of the spatial marker molecules mentioned by Stuermer (1990).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Rearing Light Level and Duration Differences on the Optic Nerve, Brain, and Associated Structures in Developing Zebrafish Larvae: A Light and Transmission Electron Microscope Study

Chapman

Tarboush

Connaughton

2012

The Anatomical Record

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The ultrastructure of the optic nerve, brain, and some associated structures of larval zebrafish, grown under three different light regimens were studied. Fish grown under cyclic light (control), constant dark (CD), and constant light (CL) were studied for 4 and 8 days postfertilization (dpf). We also studied the control and CD fish at 15 dpf. The brains of the control and CL fish were larger at 4 dpf than at 8 dpf. In all 4 dpf fish, the brain occupied the entire expanse between the two retinas and the optic nerve extended the shortest distance between the retina and the brain. The 15 dpf zebrafish had the smallest brain size. Groups of skeletal muscle cells associated with the optic nerves became visible in all older larvae. In the 15 dpf larvae, bulges and dilations in the optic nerve occurred as it reached the brain and optic chiasms occurred proximal to the brain. Electron microscopy yielded information about myelinated and unmyelinated axons in the optic nerve, the dimensions of neurotubules, neurofilaments, and myofilaments, including a unique variation in actin myofilaments, and a confirmation of reported myosin myofilament changes (but with dimensions). We also describe the ultrastructure of a sheath-like structure that is confluent over the optic nerve and the brain, which has not been described before in zebrafish. Also presented are images of associated fibroblasts, epithelial cells lining the mouth, cartilage plates, blood vessels, nerve bundles, and skeletal muscle cells, most of which have not been previously described in the literature. Anat Rec, 295:515-531,

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