Abstract:Iroquois Homeobox 4 (IRX4) belongs to a family of homeobox TFs having
roles in embryogenesis, cell specification and organ development.
Recently, Large scale Genome-Wide Association studies and epigenetic
studies have highlighted the role of IRX4 and its associated
variants in prostate cancer. No studies have investigated and
characterized the structural aspect of the IRX4 homeodomain and its
potential to bind to DNA. The current study uses sequence analysis,
homology modelling and molecular dynamics simulatio… Show more
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