Dynamics and Determinants of Pneumococcal Antibodies Specific against 13 Vaccine Serotypes in the Pre-Vaccination Era

Ginkel, Annemarijn C Prins-van; Berbers, Guy A. M.; Grundeken, Lucienne H.; Tcherniaeva, Irina; Wittenberns, Jelle I.; Elberse, Karin E. M.; Mollema, Liesbeth; Melker, Hester E. de; Knol, Mirjam J.

doi:10.1371/journal.pone.0147437

Cited by 5 publications

(4 citation statements)

References 24 publications

(40 reference statements)

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“…We discovered that the current prevalence resembled the prevalence of the early post-PCV7 vaccination period. Possibly, the initial change was due to an unfortunate coincidence of a low circulation of 19A, due to natural fluctuation, immediately after PCV7 introduction (40).…”

Section: Discussionmentioning

confidence: 99%

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A

et al. 2021

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Streptococcus pneumoniae serotype 19A prevalence has increased after implementation of PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pneumococcal disease patients and asymptomatic carriers obtained in the period 2004-2016. Whole genomes of the 338 pneumococcal isolates in this cohort were sequenced and their capsule ( cps ) loci compared to examine the diversity and determine the impact on the production of CPS sugar precursors and CPS shedding. We discovered 79 types with a unique CPS locus sequence. Most variation was observed in the rmlB and rmlD genes of the TDP-Rha synthesis pathway, and in the wzg gene, of unknown function. Interestingly, gene variation in the cps locus was conserved in multiple alleles. Using RmlB and RmlD protein models, we predict that enzymatic function is not affected by the single nucleotide polymorphisms as identified. To determine if RmlB and RmlD function was affected, we analyzed nucleotide sugar levels using UHPLC-MS. CPS precursors differed between 19A cps locus subtypes, including TDP-Rha, but no clear correlation was observed. Also, a significant difference in multiple nucleotide sugar levels was observed between phylogenetically branched groups. Because of indications of a role for Wzg in capsule shedding, we analyzed if this was affected. No clear indication of a direct role in shedding was found. We thus describe genotypic variety in rmlB , rmlD and wzg in serotype 19A the Netherlands, for which we have not discovered an associated phenotype.

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Section: Discussionmentioning

confidence: 99%

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A

et al. 2021

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“…First, we cannot causally link the introduction of PCV7 or PCV13 to the changes observed in pneumococcal serotypes. Shifts in the distribution of pneumococcal serotypes are known to occur over time; these changes have not been well explained but could represent loss of virulence in certain serotypes, development of type-specific immunity in populations, or other unmeasured ecological factors [36,39]. Changes in diversity could also be due to factors other than serotype replacement caused by vaccine-induced selective pressure (eg, unmasking of minority serotypes) [40].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Epidemiological Evidence of the Red Queen Hypothesis in Pneumococcal Serotype Dynamics

et al. 2016

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“…In P1, only educational level as SES indicator was available. Antibody concentrations against HiB, MenC, and pneumococcus were determined in a similar manner in P1 and P2 ( 15 , 19 ). For measles, mumps, rubella, and varicella antibodies were determined with ELISAs instead of MIAs ( 20 – 23 ), which showed good correlation between the assays ( 13 ).…”

Section: Methodsmentioning

confidence: 99%

Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands

Hoes

Boef

Knol

et al. 2018

Front. Public Health

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Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens.Methods: We analyzed the association between SES [educational level and net household income (NHI)] and serum IgG concentration against measles, mumps, rubella, varicella, Haemophilus influenzae type B (HiB), pneumococcus, meningococcus serogroup C (MenC), and cytomegalovirus (CMV) collected within a national cross-sectional serosurvey (2006/2007) using linear regression analyses among non-vaccinated individuals.Results: Higher educational level was associated with higher IgG concentrations against measles (GMC ratio 1.34, 95% CI 1.18–1.53) and rubella (1.13, 1.02–1.25) compared to low education level. In contrast, higher education level was associated with lower IgG concentrations against pneumococcus (0.78, 0.70–0.88), MenC (0.54, 0.44–0.68), and CMV (0.23, 0.18–0.31) compared to low education level. This pattern was also evident when NHI was used as SES indicator.Conclusion: Our study suggests that socioeconomic status is associated with antibody levels in a pathogen-dependent manner. The results suggest that differences in serological response upon infection or differences in exposure might be involved in the variation in IgG levels between SES groups.

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Dynamics and Determinants of Pneumococcal Antibodies Specific against 13 Vaccine Serotypes in the Pre-Vaccination Era

Cited by 5 publications

References 24 publications

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A

Clinical and Epidemiological Evidence of the Red Queen Hypothesis in Pneumococcal Serotype Dynamics

Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands

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