Dynamically crosslinked protien hydrogel composite as multifunctional wound dressing for cutaneous infection

Xie, Wanli; Zhang, Jinyi; Chen, Xu; Pan, Jianming; Zhang, Yijian; Pan, Guoqing

doi:10.1016/j.colcom.2022.100654

Cited by 11 publications

(12 citation statements)

References 47 publications

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“…reported a composite self‐healing hydrogel by utilizing phenyl boronic acid (PBA) modified gelatin and polyvinyl alcohol for wound healing applications. [ 271 ] Step strain‐sweep measurements confirmed the reversibility of the cross‐links ( Figure a). Moreover, the hydrogels demonstrated self‐healing behavior (Figure 7b).…”

Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 70%

“…b) Self‐healing behavior of composite hydrogel system, c) In vitro degradation rate of dynamic gels with respect of increasing PBA amount, Adapted with permission. [ 271 ] Copyright 2022, Elsevier. d) A schematic representation of reversible boronate‐ester‐diol bonding between GelNB‐BA and PEG4SH.…”

Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 99%

“…[263][264][265][266][267][268] Recently, gelatinbased matrices have been developed using reversible cross-links that show stress-relaxing behavior. [269][270][271][272] The following section highlights these reversible physical and covalent cross-linking strategies that are, or can be, applied either alone or in combination with irreversible covalent cross-linking chemistries to develop gelatin-based bioinks (Figure 5d).…”

Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 99%

“…(ai-iii)Step strain-sweeps of composite hydrogels (phenyl boronic acid (PBA) modified gelatin and polyvinyl alcohol) with different amounts of PBA (PBA amounts in Gel 3 > Gel 2 > Gel 1). b) Self-healing behavior of composite hydrogel system, c) In vitro degradation rate of dynamic gels with respect of increasing PBA amount, Adapted with permission [271]. Copyright 2022, Elsevier.…”

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confidence: 99%

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Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Asim

Tabish

Liaqat

et al. 2023

Adv Healthcare Materials

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Gelatin is a widely utilized bioprinting biomaterial due to its cell‐adhesive and enzymatically cleavable properties, which improve cell adhesion and growth. Gelatin is often covalently cross‐linked to stabilize bioprinted structures, yet the covalently cross‐linked matrix is unable to recapitulate the dynamic microenvironment of the natural extracellular matrix (ECM), thereby limiting the functions of bioprinted cells. To some extent, a double network bioink can provide a more ECM‐mimetic, bioprinted niche for cell growth. More recently, gelatin matrices are being designed using reversible cross‐linking methods that can emulate the dynamic mechanical properties of the ECM. This review analyzes the progress in developing gelatin bioink formulations for 3D cell culture, and critically analyzes the bioprinting and cross‐linking techniques, with a focus on strategies to optimize the functions of bioprinted cells. This review discusses new cross‐linking chemistries that recapitulate the viscoelastic, stress‐relaxing microenvironment of the ECM, and enable advanced cell functions, yet are less explored in engineering the gelatin bioink. Finally, this work presents the perspective on the areas of future research and argues that the next generation of gelatin bioinks should be designed by considering cell–matrix interactions, and bioprinted constructs should be validated against currently established 3D cell culture standards to achieve improved therapeutic outcomes.

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Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 70%

Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 99%

Section: Improving Cell Function In Gelatin Bioinks Using Reversible ...mentioning

confidence: 99%

mentioning

confidence: 99%

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Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Asim

Tabish

Liaqat

et al. 2023

Adv Healthcare Materials

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“…Injured skin is highly susceptible to exogenous pathogenic microorganisms and the manifestation of infection, leading to chronic conditions and delays in the healing process, increased frequency and duration of hospitalization, and risk of amputation. [7][8][9][10][11] Complete closure of wounds and tissue regeneration are the main goals of skin tissue engineering, which includes various tissue-engineered skin products aimed at flexible and efficient restoration of essential skin functions, primarily as a barrier between the internal structures of a human organism and the external environment, and then as a protection of the whole immune system and defence mechanisms against external harmful substances. [12] The need for efficient tissue engineering products is constantly increasing, mainly due to the threat of the development of bacterial resistance to a wide range of antibacterial drugs commonly used in wound treatment.…”

Section: Introductionmentioning

confidence: 99%

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Vuković,

Radić1,

Trifunović

et al. 2023

Macro Chemistry & Physics

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Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult‐to‐treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH‐sensitive antibacterial hydrogel dressings, Zn2+‐loaded poly(2‐hydroxyethyl acrylate/itaconic acid) hydrogels were synthesized. The hydrogels exhibit pH‐sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37°C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger‐Peppas and Peppas‐Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.This article is protected by copyright. All rights reserved

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Human collagen decorating microneedle patches for transdermal therapy

Zheng,

Zhou,

Xiao

et al. 2023

Journal of Polymer Science

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Collagen, the major structural protein in various tissues, is an ideal material for tissue regeneration. However, the collagen molecules cannot penetrate across the skin barrier due to their large molecular weight. It is necessary to develop new methods of delivery for promoting the collagen‐based therapy. Microneedle patches have been used in drug delivery applications as an alternative to traditional puncture delivery. In this study, the human collagen decorating microneedle patch was developed to deliver the collagen into the skin tissue, as the human‐source collagen can overcome the immunogenicity of animal‐source collagens in regenerative applications. The human collagen is usually limited by its source. Here, the collagen is derived from an allogeneic extracellular matrix expressed by human stem cells in vitro. The collagen was then loaded on the tip of the microneedle to achieve a high‐loading dose and efficient delivery. The experimental results proved that the microneedles were sharp and rigid enough to pierce the skin, which has the potential to be used for subcutaneous tissue regeneration. Moreover, the fabrication process was simple and effective to realize large‐scale production.

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Dynamically crosslinked protien hydrogel composite as multifunctional wound dressing for cutaneous infection

Cited by 11 publications

References 47 publications

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Human collagen decorating microneedle patches for transdermal therapy

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Dynamically crosslinked protien hydrogel composite as multifunctional wound dressing for cutaneous infection

Cited by 11 publications

References 47 publications

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Zn2+/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings

Human collagen decorating microneedle patches for transdermal therapy

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Product

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Zn²⁺/Poly(2‐Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings