Dynamical Response of Nanomechanical Oscillators in Immiscible Viscous Fluid for<i>In Vitro</i>Biomolecular Recognition

Dorignac, Jérôme; Kalinowski, Agnieszka; Erramilli, Shyamsunder; Mohanty, Pritiraj

doi:10.1103/physrevlett.96.186105

Cited by 61 publications

(64 citation statements)

References 17 publications

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“…The successful race for miniaturization of semiconductor technologies 2 manifests itself spectacularly in the form of nanoelectromechanical systems (NEMS) 3,4,5,6 , machines in the micron and submicron scale whose mechanical motion, integrated into electrical circuits, has a wealth of technological applications, including control of currents at the single-electron level 7 , single-spin detection 8 , sub-attonewton force detection 9 , mass sensing of individual molecules 10 , high-precision thermometry 11 or in-vitro single-molecule biomolecular recognition 12 .…”

Section: Introductionmentioning

confidence: 99%

Surface dissipation in nanoelectromechanical systems: Unified description with the standard tunneling model and effects of metallic electrodes

2008

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Modifying and extending recent ideas 1 , a theoretical framework to describe dissipation processes in the surfaces of vibrating micro and nanoelectromechanical devices (MEMS-NEMS), thought to be the main source of friction at low temperatures, is presented. Quality factors as well as frequency shifts of flexural and torsional modes in doubly-clamped beams and cantilevers are given, showing the scaling with dimensions, temperature and other relevant parameters of these systems. Full agreement with experimental observations is not obtained, leading to a discussion of limitations and possible modifications of the scheme to reach quantitative fitting to experiments. For NEMS covered with metallic electrodes the friction due to electrostatic interaction between the flowing electrons and static charges in the device and substrate is also studied.

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Section: Introductionmentioning

confidence: 99%

Surface dissipation in nanoelectromechanical systems: Unified description with the standard tunneling model and effects of metallic electrodes

2008

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“…If the Reynolds number decreases as a result of increasing viscosity or smaller b, the viscous contribution grows more significant, and two things occur: the resonant frequency shifts further downward, and the peak widens as cantilever motion is damped (Sader 1998, Dorignac et al 2006, Fritz 2008). The quality factor, Q, is a measure of the energy lost in one period of cantilever vibration:…”

Section: Dynamic Cantilever Sensorsmentioning

confidence: 99%

Nucleic acid electrochemical and electromechanical biosensors: a review of techniques and developments

Rosario

Mutharasan

2014

Reviews in Analytical Chemistry

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This review comprises the last decade's development on experimental techniques for electrochemical and electromechanical sensing of nucleic acids, which originate from pathogenic bacteria, parasites, and viruses commonly found in food, water, and medical context. The electrochemical devices that are of primary interest are those that use voltammetry for detecting DNA and RNA-associated electrochemically active molecules at the working electrode. Attograms of nucleic acids have been reported to be detectable with electrochemical sensors in a batch-mode measurement arrangement. The masssensing electromechanical devices sense nucleic acids at the femtogram levels in a flow format without a molecular technique for amplifying target strand using polymerase chain reaction. Both underlying physics and methods of various studies are summarized, with discussion on limitations and potentials. We call attention to the need for sensors that not only detect but also confirm detection, as false negatives are not acceptable when one measures pathogenic species.

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“…By solving this inverse problem, we actually provide a viable experimental method to determine the effects of both surface elasticity and surface stress. Because the surface stress effect is modelled as an axial load on the structure, two different models arise: the concentrated load model [3][4][5][6][7][8]13,16,24,[35][36][37] and the distributed load model [35][36][37]. The difference between these two models is also discussed.…”

Section: Introductionmentioning

confidence: 99%

Determining the effects of surface elasticity and surface stress by measuring the shifts of resonant frequencies

2013

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Both surface elasticity and surface stress can result in changes of resonant frequencies of a micro/nanostructure. There are infinite combinations of surface elasticity and surface stress that can cause the same variation for one resonant frequency. However, as shown in this study, there is only one combination resulting in the same variations for two resonant frequencies, which thus provides an efficient and practical method of determining the effects of both surface elasticity and surface stress other than an atomistic simulation. The errors caused by the different models of surface stress and mode shape change due to axial loading are also discussed.

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Dynamical Response of Nanomechanical Oscillators in Immiscible Viscous Fluid forIn VitroBiomolecular Recognition

Cited by 61 publications

References 17 publications

Surface dissipation in nanoelectromechanical systems: Unified description with the standard tunneling model and effects of metallic electrodes

Surface dissipation in nanoelectromechanical systems: Unified description with the standard tunneling model and effects of metallic electrodes

Nucleic acid electrochemical and electromechanical biosensors: a review of techniques and developments

Determining the effects of surface elasticity and surface stress by measuring the shifts of resonant frequencies

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