Dynamical properties of the brain tissue under oscillatory shear stresses at large strain range

Boudjema, F.; Khelidj, B.; Mourad, Lounis

doi:10.1088/1742-6596/790/1/012002

Cited by 5 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In direct contrast, gray matter from the thalamus has also been found to be 1.3 times stiffer than the white matter found in the corpus callosum (Prange and Margulies, 2002). As a result, the proportions of gray and white matter must be consistent in order to accurately compare the stress relaxation response between different brain tissue samples (Budday et al, 2017;Boudjema et al, 2017;Finan et al, 2017;Jin et al, 2013;Prange and Margulies, 2002). In this study, samples were extracted from the same region of the brain while striving for a consistent anatomical structure.…”

Section: Discussionmentioning

confidence: 99%

“…Since brain tissue's behavior is affected by strain rate and displays hysteresis, it is best described by a viscoelastic model (Bentil and Dupaix, 2014;Boudjema et al, 2017;Donnelly and Medige, 1997;Finan et al, 2017;Galford and McElhaney, 1970;Green et al, 2008;Jin et al, 2013;Klatt et al, 2007;Kleiven, 2007;Miller and Chinzei, 1997;Rashid et al, 2012;Takhounts et al, 1999;Tirella et al, 2013). In this study, the fractional Zener (FZ) constitutive model was used to quantify the mechanical behavior of brain tissue during unconfined compression experiments.…”

Section: Fractional Zener Constitutive Modelmentioning

confidence: 99%

See 1 more Smart Citation

Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experiments

McCarty

Zhang

Hansen

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing unconfined compression experiments. This study aimed to investigate the effect of a time delay on the viscoelastic properties in the event that an experiment cannot be completed immediately. Samples from both soaked and freshly extracted brains were subjected to compressive rates of 5, 50, and 500 mm/min during the unconfined compression experiments. The fractional Zener (FZ) viscoelastic model was applied to obtain the brain's material properties. The length of time in the solution statistically influenced three of the four FZ coefficients, E 0 (instantaneous elastic response), τ 0 (relaxation time), and α (fractional order). Further, the compressive rate statistically influenced τ 0 and α. AbstractTraumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing unconfined compression experiments. This study aimed to investigate the effect of a time delay on the viscoelastic properties in the event that an experiment cannot be completed immediately. Samples from both soaked and freshly extracted brains were subjected to compressive rates of 5, 50, and 500 mm/min during the unconfined compression experiments. The fractional Zener (FZ) viscoelastic model was applied to obtain the brain's material properties. The length of time in the solution statistically influenced three of the four FZ coefficients, E 0 (instantaneous elastic response), τ 0 (relaxation time), and α (fractional order). Further, the compressive rate statistically influenced τ 0 and α.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Fractional Zener Constitutive Modelmentioning

confidence: 99%

Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experiments

McCarty

Zhang

Hansen

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

show abstract

“…In comparison to a study [40] on the compressive viscoelastic properties of porcine brain tissue where the mean storage and loss moduli were 8.09 kPa and 4.85 kPa, respectively, the bovine brain in this study had higher dynamic moduli at comparable frequencies. In addition, animal brain tissues were tested using dynamic shear [61] and tensile methods [45] to analyze the oscillatory characterization. Despite comparisons being limited by the potential discrepancies in the types of loading and tested specimen species, the general trends of the dynamic storage and loss moduli against frequency were found to be similar.…”

Section: Discussionmentioning

confidence: 99%

Dynamic mechanical characterization and viscoelastic modeling of bovine brain tissue

Shepherd

Espino

2021

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

“…Brain tissue can be described by a viscoelastic model since the tissue is strain rate dependent and hysteresis applies (Bentil and Dupaix, 2014;Boudjema et al, 2017;Donnelly and Medige, 1997;Finan et al, 2017;Galford and McElhaney, 1970;Green et al, 2008;Jin et al, 2013;Klatt et al, 2007;Kleiven, 2007;Miller and Chinzei, 1997;Rashid et al, 2012a;Takhounts et al, 1999;Tirella et al, 2013). In order to best describe the brain's viscoelastic behavior from the unconfined compression experiments, the fractional Zener constitutive model was used to obtain the material properties capturing the stress relaxation behavior.…”

Section: Fractional Zener Constitutive Modelmentioning

confidence: 99%

“…Since the brain is an inhomogeneous material, the material properties for the white and gray matter are different. As such, any differences in the relative amount of gray and white matter between two brain samples would affect the stress relaxation response (Budday et al, 2017;Boudjema et al, 2017;Finan et al, 2017;Jin et al, 2013;Prange and Margulies, 2002). As a result, when coring the brain samples, care was taken to extract from the same region of the brain for consistency in the anatomical structure.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Influence of saline solution absorption and compressive rate on the material properties of brain tissue

McCarty

Zhang

Hansen

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Traumatic brain injuries (TBI) affect millions of people each year and can result in long-term difficulties in thinking or focusing. Due to the number of people affected by these injuries, significant research has been dedicated to determining the mechanical properties of the brain using postmortem tissue from animals harvested within 24 hours. The postmortem brain tissue is often stored in a solution until a rheological experiment is ready to begin. However, the effect of storage duration on the mechanical behavior of brain tissue is not understood. In this paper, postmortem porcine brains were placed in normal saline solution (0.9% NaCl) and refrigerated between 30 minutes and 6.5 hours to allow the brain to absorb the solution. Afterwards, samples from both soaked and freshly extracted brains were subjected to unconfined compression tests at compressive rates of 5, 50, and 500 mm/min. The fractional Zener viscoelastic model was applied to obtain the brain's mechanical properties. While the results did not show a significant relationship between absorption and the long-term stiffness (E ∞ ), both the relaxation time (τ 0 ) and fractional order (α) were statistically influenced by both the length of time in the solution and compressive rate. Further, the instantaneous stiffness (E 0 ) was statistically influenced by the length of time in solution, though not the compressive rate.

show abstract

Dynamical properties of the brain tissue under oscillatory shear stresses at large strain range

Cited by 5 publications

References 10 publications

Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experiments

Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experiments

Dynamic mechanical characterization and viscoelastic modeling of bovine brain tissue

Influence of saline solution absorption and compressive rate on the material properties of brain tissue

Contact Info

Product

Resources

About